Strain Report - Rat Genome Database

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Strain: W-Il2rgem1Hina

Symbol: W-Il2rgem1Hina
Strain: W-Il2rgem1
Substrain: Kyo
RGD ID: 9685757
Citation ID: RRID:RGD_9685757
Ontology ID: RS:0003857
Alleles: Il2rgem1Hina
Also known as: Wistar-X-SCID; W-Il2rgKO /Hina; NBRP Rat No: 0696; W-Il2rgem1Hina
Type: mutant
Source: National BioResource Project for the Rat in Japan
Origin: This strain was generated by electroporation method: introduction of Il2rg gene-targeting vector (PKG promoter-HSV TK, loxp Tk2 promoter-Neor loxp) into ES cells of Wistar rat(Crlj:Wistar)
Coat Color: Albino
Last Known Status: Cryopreserved Embryo (as of 2017-03-27)
Research Usage Immunology
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X66,395,330 - 66,399,026RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X71,165,378 - 71,169,078RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0X72,017,856 - 72,021,516RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4X89,342,055 - 89,345,715RGD_MAPPER_PIPELINERGSC3.4


References - curated
1. Personal Communication with NBRP
2. RGD Automated Pipelines


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This strain shows severe combined immunodeficiency (SCID) caused by a 636-bp deletion between Exon7 and Intron8 in the Il2rg gene and knock-in of neomycin resistance gene. This strain can grow normally under SPF condition. 1302502
strain_reproduction Maintained by mating of hemizygous male and heterozygous female. 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-05-27 W-Il2rgem1Hina    W-Il2rgem1Hina    Name updated 68913 APPROVED
2015-05-27 W-Il2rgem1Hina    W-Il2rgem1Hina    Name updated 68913 APPROVED