Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul

Symbol: ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul
Strain: ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)
Substrain: Shul
RGD ID: 9589088
Citation ID: RRID:RRRC_00743
Ontology ID: RS:0003846
Also Known As: ACWi; ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul
Type: congenic
Available Source: Rat Resource and Research Center
Origination: Department of Oncology, McArdle Laboratory for Cancer Research, University of Wisconsin-Madison
Description: This congenic strain contains regions of COP/CrCrl chromosome 3 and COP/CrCrl chromosome 6 transferred to the ACI/SegHsd strain background.
Coat Color: Agouti
Last Known Status: Cryorecovery (as of 2019-02-26)






References

References - curated
# Reference Title Reference Citation
1. Development and characterization of a novel rat model of estrogen-induced mammary cancer. Dennison KL, etal., Endocr Relat Cancer. 2015 Apr;22(2):239-48. doi: 10.1530/ERC-14-0539.
2. Data registered by Dr. James D. Shull's group Personal communication between Dr. James D. Shull's group and the RGD curators
3. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Exhibits ACI-like susceptibility to 17b-estradiol- induced mammary cancer, but, like the COP model, lacks treatment related morbidity associated with pituitary lactotroph hyperplasia/adenoma. It is well suited for investigators focusing on mammary cancer etiology, particularly in long-term studies. 2292495
strain_other This strain is a homozygous inbred double congenic harboring COP/CrCrl alleles at the Ept1 locus on RNO6 and the Ept2 locus on RNO3, introgressed onto ACI/SegHsd genomic background. The strain was generated by intercrossing ACI.COP-Ept1 (RGD ID 2292564) and ACI.COP-Ept2 (RGD ID 2292566) homozygous inbred rat strains and selectively breeding progeny for animals homozygous for COP alleles across both loci. 2292495

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-26 ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul    ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul    Name updated 68913 APPROVED
2016-05-26 ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul    ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul    Name updated 68913 APPROVED
2016-05-25 ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul    ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul    Name updated 68913 APPROVED
2016-05-25 ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul    ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul    Name updated 68913 APPROVED
2014-11-19 ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul    ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul    Name updated 68913 APPROVED
2014-11-19 ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul    ACI.COP-(D3Rat130-D3Rat114)(D6Rat80-D6Rat146)/Shul    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00743 RGD