Strain Report - Rat Genome Database

Name: W- Lepr faNin
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Strain Registration

General

Strain: W-Lepr^faNin
Symbol:	W-Lepr^faNin
Strain:	W-Lepr^fa
Substrain:	Nin
RGD ID:	8655992
Citation ID:	RRID:RGD_8655992
Ontology ID:	RS:0003774
Previously known as:	WNIN-Ob; WNIN-Obese; WNIN/Ob (-/-); W-LeprfaNin
Type:	mutant
Source:	National Institute of Nutrition (NIN), Hyderabad, India
Origin:	The spontaneously developed obese rat was derived from the colony of inbred W/Nin by selective breeding. Its lean litter mate ( W-Lepr+/+/Nin, RGD:8655977) was used as a control strain in obesity related study.
Last Known Status:	Unknown

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

obesity (IAGP)

retinal degeneration (IAGP)

Weight Gain (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal photoreceptor outer segment morphology (IAGP)

abnormal retinol level (IAGP)

decreased body weight (IAGP)

decreased retina photoreceptor cell number (IAGP)

increased body weight (IAGP)

increased circulating glucose level (IAGP)

oxidative stress (IAGP)

retina degeneration (IAGP)

thin retina outer nuclear layer (IAGP)

thin retina outer plexiform layer (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

Options:

View chart

Download data table

View expanded data table

Clinical Measurement

References

References - curated

#	Reference Title	Reference Citation
1.	Obese locus in WNIN/obese rat maps on chromosome 5 upstream of leptin receptor.	Kalashikam RR, etal., PLoS One. 2013 Oct 21;8(10):e77679. doi: 10.1371/journal.pone.0077679. eCollection 2013.
2.	A novel rat model with obesity-associated retinal degeneration.	Reddy GB, etal., Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3456-63. doi: 10.1167/iovs.08-2498. Epub 2009 Apr 15.
3.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
4.	Increased macromolecular damage due to oxidative stress in the neocortex and hippocampus of WNIN/Ob, a novel rat model of premature aging.	Sinha JK, etal., Neuroscience. 2014 Jun 6;269:256-64. doi: 10.1016/j.neuroscience.2014.03.040. Epub 2014 Apr 5.
5.	Vitamin A supplementation ameliorates obesity-associated retinal degeneration in WNIN/Ob rats.	Tiruvalluru M, etal., Nutrition. 2013 Jan;29(1):298-304. doi: 10.1016/j.nut.2012.06.006. Epub 2012 Oct 2.

Region

Strain QTL Data

Symbol	Name	Trait
Bw146	Body weight QTL 146	body mass (VT:0001259)

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_life_disease	obesity-associated retinal degeneration was alleviated by vitamin A supplementation	8657053

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2014-05-27	W-Lepr^faNin	W-Lepr^faNin	Name updated	68913	APPROVED
2014-05-27	W-Lepr^faNin	W-Lepr^faNin	Name updated	68913	APPROVED
2014-05-27	W-Lepr^faNin	W-Lepr^faNin	Name updated	68913	APPROVED
2014-05-27	W-Lepr^faNin	W-Lepr^faNin	Name updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Strain: W-Lepr^faNin

Mammalian Phenotype

Related Phenotype Data for Term "W-LeprfaNin" (RS:0003774)

Create Name:

Description:

Send us a Message

Strain: W-LeprfaNin

Mammalian Phenotype

Related Phenotype Data for Term "W-LeprfaNin" (RS:0003774)

Strain: W-Lepr^faNin