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Strain: W-LeprfaNin

Symbol: W-LeprfaNin
Strain: W-Leprfa
Substrain: Nin
RGD ID: 8655992
Citation ID: RRID:RGD_8655992
Ontology ID: RS:0003774
Previously known as: WNIN-Ob; WNIN-Obese; WNIN/Ob (-/-); W-LeprfaNin
Type: mutant
Source: National Institute of Nutrition (NIN), Hyderabad, India
Origin: The spontaneously developed obese rat was derived from the colony of inbred W/Nin by selective breeding. Its lean litter mate ( W-Lepr+/+/Nin, RGD:8655977) was used as a control strain in obesity related study.
Last Known Status: Unknown





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References

References - curated
# Reference Title Reference Citation
1. Obese locus in WNIN/obese rat maps on chromosome 5 upstream of leptin receptor. Kalashikam RR, etal., PLoS One. 2013 Oct 21;8(10):e77679. doi: 10.1371/journal.pone.0077679. eCollection 2013.
2. A novel rat model with obesity-associated retinal degeneration. Reddy GB, etal., Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3456-63. doi: 10.1167/iovs.08-2498. Epub 2009 Apr 15.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Increased macromolecular damage due to oxidative stress in the neocortex and hippocampus of WNIN/Ob, a novel rat model of premature aging. Sinha JK, etal., Neuroscience. 2014 Jun 6;269:256-64. doi: 10.1016/j.neuroscience.2014.03.040. Epub 2014 Apr 5.
5. Vitamin A supplementation ameliorates obesity-associated retinal degeneration in WNIN/Ob rats. Tiruvalluru M, etal., Nutrition. 2013 Jan;29(1):298-304. doi: 10.1016/j.nut.2012.06.006. Epub 2012 Oct 2.

Region

Strain QTL Data
Symbol Name Trait
Bw146 Body weight QTL 146 body mass   (VT:0001259)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease obesity-associated retinal degeneration was alleviated by vitamin A supplementation 8657053

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-05-27 W-LeprfaNin    W-LeprfaNin    Name updated 68913 APPROVED
2014-05-27 W-LeprfaNin    W-LeprfaNin    Name updated 68913 APPROVED
2014-05-27 W-LeprfaNin    W-LeprfaNin    Name updated 68913 APPROVED
2014-05-27 W-LeprfaNin    W-LeprfaNin    Name updated 68913 APPROVED