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Strain Registration

Strain: DA.PVG.1AV1-(D10Got6-D10Rat184)/Kini

Symbol: DA.PVG.1AV1-(D10Got6-D10Rat184)/Kini
Strain: DA.PVG.1AV1-(D10Got6-D10Rat184)
Substrain: Kini
RGD ID: 8552341
Citation ID: RRID:RGD_8552341
Ontology ID: RS:0003747
Previously known as: DA.PVG.1AV1-Vra4; NBRP Rat No: 0700; DA.PVG.1AV1-(D10Got6-D10Rat184)/Kini
Type: congenic
Source: Center for Molecular Medicine, Neuroimmunology Unit, Karolinska Institutet, Stockholm, Sweden, National BioResource Project for the Rat in Japan
Origin: Inbred Dark Agouti (DA) rats were originally obtained from Hannover, Germany and Piebald Virol Glaxo(PVG) rats from Harlan UK Limited (Blackthorn, UK). Congenic strain was established by transfer of the defined Vra4 segment selected from male donors of G8 generation of a DAxPVG1.AV1 andvanced intercross line. Subsequential backcrossing for 9 generations.
Coat Color: agouti
Last Known Status: Cryopreserved Sperm
Research Usage Neurobiology
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2103,406,320 - 3,406,594RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0102,847,625 - 11,561,989RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0101,728,277 - 10,319,475RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4103,219,701 - 11,568,211RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Vra4 congenic rats with allelic differences in the class II transactivator gene display altered susceptibility to experimental autoimmune encephalomyelitis. Harnesk K, etal., J Immunol. 2008 Mar 1;180(5):3289-96.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D10Got6)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2103,406,320 - 3,406,594 (+)MAPPER
Rnor_6.0102,847,625 - 2,847,898NCBI
Rnor_5.0101,728,277 - 1,728,550UniSTS
RGSC_v3.4103,219,701 - 3,219,975RGD
RGSC_v3.4103,219,702 - 3,219,975UniSTS
RGSC_v3.1103,219,701 - 3,219,975RGD
Celera102,440,770 - 2,441,043UniSTS

Flank 2 / 1 (D10Rat184)
Rat AssemblyChrPosition (strand)Source
Rnor_6.01011,561,841 - 11,561,989NCBI
Rnor_5.01010,319,327 - 10,319,475UniSTS
RGSC_v3.41011,567,780 - 11,567,932UniSTS
RGSC_v3.41011,567,738 - 11,568,211RGD
RGSC_v3.11011,567,780 - 11,567,932RGD
Celera1010,263,351 - 10,263,495UniSTS
RH 3.4 Map10128.25RGD
RH 3.4 Map10128.25UniSTS
SHRSP x BN Map105.71UniSTS
SHRSP x BN Map105.71RGD

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Lower expression of MHC class II on B cells, milder disease course due to EAE compared to DA. 1302502
strain_reproduction Good breeding performances. 1302502