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Strain: KDP.PVG-RT1a/u/Nyo

Symbol: KDP.PVG-RT1a/u/Nyo
Strain: KDP.PVG-RT1a/u
Substrain: Nyo
RGD ID: 8548817
Citation ID: RRID:RGD_8548817
Ontology ID: RS:0003643
Previously known as: KDP.PVG-RT1a/u congenic; KP congenic; NBRP Rat No: 0625; KDP.PVG-RT1a/u/Nyo
Type: congenic
Source: National BioResource Project for the Rat in Japan
Origin: MHC haplotype (RT1.BaDa) of PVG.R23 was transferred onto the genetic background of KDP/Tky strain (RT1.BuDu). This allele has been maintained in heterozygous condition. Backcrossing has started since 2003 and afterwards maintained by sib mating
Coat Color: black hooded
Inbred Generations: F6
Last Known Status: Cryopreserved Sperm
Research Usage Diabetes Obesity


References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred strain. Yokoi N, etal., Exp Anim 2003 Jul;52(4):295-301.


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics The rats homozygous for the RT1u/u develop diabetes frequently similar to that of KDP rats (RT1u/u). RT1a/u heterozygous rats develops diabetes with low frequency. RT1a/a homozygous rats do not develop diabetes. Both RT1a/u and RT1a/a rats exhibit thyroidititis 1302502
strain_reproduction Maintained by crossing between heterozygotes of the MCH and Cblb locus 1302502