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Strain Registration

Strain: BN/Crl

Symbol: BN/Crl
Strain: BN
Substrain: Crl
RGD ID: 737972
Citation ID: RRID:RGD_737972
Ontology ID: RS:0000134
Also Known As: BN_EC_Array7; BN/CrlBR
Type: inbred
Available Source: Charles River Laboratories
Origination: Charles River Laboratories
Description: Silvers and Billingham began brother x sister matings with selection for histocompatibility in 1958 from a brown mutation in a stock of wild rats maintained by King and Aptekman in a pen-bred colony of rats trapped from the wild in 1930 by King at the Wistar Institute. To Charles River from Radiobiology Institute, Netherlands in 1976.
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View
Toxemia  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats. Collins SC, etal., Mamm Genome. 2006 Jun;17(6):538-47. Epub 2006 Jun 12.
2. Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models. Dumas ME, etal., Nat Genet. 2007 Apr 15;.
3. Chromosomal mapping of pancreatic islet morphological features and regulatory hormones in the spontaneously diabetic (Type 2) Goto-Kakizaki rat. Finlay C, etal., Mamm Genome. 2010 Oct;21(9-10):499-508. Epub 2010 Sep 29.
4. Single Nucleotide Polymorphisms associated with rat expressed sequences. Guryev V, etal., Genome Res. 2004 Jul;14(7):1438-43.
5. Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants. Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
6. Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats. Kim K, etal., Physiol Genomics. 2010 Feb 16.
7. Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment. Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.
8. Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1. Newman ZL, etal., PLoS Pathog. 2010 May 20;6(5):e1000906. doi: 10.1371/journal.ppat.1000906.
9. RGD Strain RSO annotation pipeline RGD Automated Pipelines
10. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
11. Genetic variation in coding regions between and within commonly used inbred rat strains. Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.
12. Genetic isolation of a chromosome 1 region affecting susceptibility to hypertension-induced renal damage in the spontaneously hypertensive rat. St Lezin E, etal., Hypertension 1999 Aug;34(2):187-91.
13. Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat. St. Lezin E, etal., Hypertension 1997 Oct;30(4):854-9
14. Leptin receptor interacts with rat chromosome 1 to regulate renal disease traits. Warden CH, etal., Physiol Genomics. 2012 Nov 1;44(21):1052-62. doi: 10.1152/physiolgenomics.00134.2011. Epub 2012 Sep 11.

Region

Strain QTL Data
Symbol Name Trait
Bp26 Blood pressure QTL 26 arterial blood pressure trait   (VT:2000000)    
Bw124 Body weight QTL 124 body mass   (VT:0001259)    
Bw125 Body weight QTL 125 retroperitoneal fat pad mass   (VT:0010430)    
Kidm42 Kidney mass QTL 42 kidney mass   (VT:0002707)    
Niddm67 Non-insulin dependent diabetes mellitus QTL 67 blood glucose amount   (VT:0000188)    
Niddm69 Non-insulin dependent diabetes mellitus QTL 69 blood insulin amount   (VT:0001560)    
Pancm2 Pancreatic morphology QTL 2 pancreatic beta cell morphology trait   (VT:0005217)    
Rends1 Renal damage susceptibility QTL 1 kidney glomerulus integrity trait   (VT:0010546)    
Scort2 Serum corticosterone level QTL 2 blood corticosterone amount   (VT:0005345)    
Stl32 Serum triglyceride level QTL 32 blood triglyceride amount   (VT:0002644)    
Uae40 Urinary albumin excretion QTL 40 urine albumin amount   (VT:0002871)    
Uae41 Urinary albumin excretion QTL 41 urine albumin amount   (VT:0002871)    
Uae42 Urinary albumin excretion QTL 42 urine albumin amount   (VT:0002871)    
Uae43 Urinary albumin excretion QTL 43 urine albumin amount   (VT:0002871)    
Uae44 Urinary albumin excretion QTL 44 urine albumin amount   (VT:0002871)    
Uae45 Urinary albumin excretion QTL 45 urine albumin amount   (VT:0002871)    
Uae46 Urinary albumin excretion QTL 46 urine albumin amount   (VT:0002871)    
Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
mRatBN7.2 BN/Crl (2021) View Damaging Variants


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203. 737878
strain_phys_biochem This strain was used for genotyping candidate single nucleotide polymorphisms; SNPs obtained from this study can be found in NCBI dbSNP under accession numbers ss12535137 - ss12568440, ss12588074 - ss12588105 or Cuppen Group 737879