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Strain: SPRD/Ztm

Symbol: SPRD/Ztm
Strain: SPRD
Substrain: Ztm
RGD ID: 737962
Citation ID: RRID:RGD_737962
Ontology ID: RS:0001449
Also Known As: SPRD-Cu3; MDC-03-20; SPRD/Han; SPRD/HanZtm
Type: inbred
Available Source: Not Available
Origination: Zentralinstitut fur Versuchstierzucht, Hannover, Germany
Description: Substrain of SPRD, from outbred Sprague-Dawley rats at the Hannover facility, where inbreeding began in 1976
Coat Color: Albino
Inbred Generations: F51
Last Known Status: Unknown

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. Biochemical markers in inbred strains of the rat (Rattus norvegicus). Bender K, etal., Immunogenetics 1984;19(3):257-66.
2. Genetic characterization of inbred strains of the rat (Rattus norvegicus). Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
3. Sequencing and chromosomal localization of Fabp6 and an intronless Fabp6 segment in the rat. Bonne A, etal., Mol Biol Rep 2003 Sep;30(3):173-6.
4. The Mcs7 quantitative trait locus is associated with an increased susceptibility to mammary cancer in congenic rats and an allele-specific imbalance. Cotroneo MS, etal., Oncogene. 2006 Aug 17;25(36):5011-7. Epub 2006 Mar 27.
5. Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants. Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
6. Institute for Animal Experimentation University of Tokushima School of Medicine Institute for Animal Experimentation University of Tokushima School of Medicine
7. Mammary cancer resistance and precocious mammary differentiation in the WKY rat: identification of 2 quantitative trait loci. Lella V, etal., Int J Cancer. 2007 Oct 15;121(8):1738-43.
8. Use of simple sequence length polymorphisms for genetic characterization of rat inbred strains. Otsen M, etal., Mamm Genome 1995 Sep;6(9):595-601.
9. Contrasting epistatic interactions between rat quantitative trait loci controlling mammary cancer development. Piessevaux G, etal., Mamm Genome. 2008 Dec 4.
10. Genetic identification of distinct loci controlling mammary tumor multiplicity, latency, and aggressiveness in the rat. Quan X, etal., Mamm Genome. 2006 Apr;17(4):310-21. Epub 2006 Apr 4.
11. RGD Strain RSO annotation pipeline RGD Automated Pipelines
12. Genetic analysis of susceptibility to endometrial adenocarcinoma in the BDII rat model. Roshani L, etal., Cancer Genet Cytogenet. 2005 Apr 15;158(2):137-41.
13. Genetic identification of multiple susceptibility genes involved in the development of endometrial carcinoma in a rat model. Roshani L, etal., Int J Cancer. 2001 Dec 15;94(6):795-9.
14. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
15. The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesis. Shull JD Breast Dis. 2007;28:69-86.
16. Genetic variation in coding regions between and within commonly used inbred rat strains. Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.
17. Isolation of two regions on rat chromosomes 5 and 18 affecting mammary cancer susceptibility. Stieber D, etal., Int J Cancer. 2007 Jan 17;.


Strain QTL Data
Symbol Name Trait
Edcs1 Endometrial carcinoma susceptibility QTL1 uterus morphology trait   (VT:0001120)    
Edcs4 Endometrial carcinoma susceptibility QTL 4 uterus morphology trait   (VT:0001120)    
Edcs5 Endometrial carcinoma susceptibility QTL 5 uterus morphology trait   (VT:0001120)    
Mcs16 Mammary carcinoma susceptibility QTL 16 mammary gland integrity trait   (VT:0010552)    
Mcs17 Mammary carcinoma susceptibility QTL 17 mammary gland integrity trait   (VT:0010552)    
Mcs18 Mammary carcinoma susceptibility QTL 18 mammary gland integrity trait   (VT:0010552)    
Mcs19 Mammary carcinoma susceptibility QTL 19 mammary gland integrity trait   (VT:0010552)    
Mcs20 Mammary carcinoma susceptibility QTL 20 mammary gland integrity trait   (VT:0010552)    
Mcs21 Mammary carcinoma susceptibility QTL 21 mammary gland integrity trait   (VT:0010552)    
Mcs22 Mammary carcinoma susceptibility QTL 22 mammary gland integrity trait   (VT:0010552)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems Females develop mammary tumors in 50-55 days when induced by 7,12 dimethybenz(alpha)anthracene (DMBA) 1599317
strain_phys_biochem This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203. 737878
strain_reproduction Good reproductive performance, average number weaned/female/week is 1.1 737882

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-03-21 SPRD/Ztm    SPRD/HanZtm    Symbol updated 68687 APPROVED
2011-03-21 SPRD/Ztm    SPRD/HanZtm    Name updated 68913 APPROVED
2011-03-21 SPRD/Ztm    SPRD/HanZtm    Symbol updated 68687 APPROVED
2011-03-21 SPRD/Ztm    SPRD/HanZtm    Name updated 68913 APPROVED