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Strain Registration

Strain: F344/NCrl

Symbol: F344/NCrl
Strain: F344
Substrain: NCrl
RGD ID: 737926
Citation ID: RRID:RGD_737926
Ontology ID: RS:0000306
Previously known as: MDC-03-21; Fischer 344; F344/CrCrlBR
Type: inbred
Source: Charles River Laboratories
Origin: Derived from NIH stock in 1992 by SASCO. To Charles River in 1996.
Coat Color: Albino
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View
Toxemia  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table


References

References - curated
# Reference Title Reference Citation
1. Genetic dissection of granulomatous enterocolitis and arthritis in the intramural peptidoglycan-polysaccharide-treated rat model of IBD. Bleich A, etal., Inflamm Bowel Dis. 2009 Jun 12;15(12):1794-1802.
2. Mapping and confirmation of a major left ventricular mass QTL on rat chromosome 1 by contrasting SHRSP and F344 rats. Grabowski K, etal., Physiol Genomics. 2013 Sep 16;45(18):827-33. doi: 10.1152/physiolgenomics.00067.2013. Epub 2013 Jul 30.
3. High-resolution quantitative trait locus analysis reveals multiple diabetes susceptibility loci mapped to intervals<800 kb in the species-conserved Niddm1i of the GK rat. Granhall C, etal., Genetics. 2006 Nov;174(3):1565-72. Epub 2006 Sep 1.
4. Single Nucleotide Polymorphisms associated with rat expressed sequences. Guryev V, etal., Genome Res. 2004 Jul;14(7):1438-43.
5. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.
6. Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1. Newman ZL, etal., PLoS Pathog. 2010 May 20;6(5):e1000906. doi: 10.1371/journal.ppat.1000906.
7. RGD Strain RSO annotation pipeline RGD Automated Pipelines
8. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
9. Genetic variation in coding regions between and within commonly used inbred rat strains. Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.
10. Modulation of estrogen action in the rat pituitary and mammary glands by dietary energy consumption. Spady TJ, etal., J Nutr 1999 Feb;129(2S Suppl):587S-590S.

Region

Strain QTL Data
Symbol Name Trait
Aia10 Adjuvant induced arthritis QTL 10 joint integrity trait   (VT:0010548)    
Aia11 Adjuvant induced arthritis QTL 11 joint integrity trait   (VT:0010548)    
Aia12 Adjuvant induced arthritis QTL 12 joint integrity trait   (VT:0010548)    
Aia13 Adjuvant induced arthritis QTL 13 joint integrity trait   (VT:0010548)    
Aia14 Adjuvant induced arthritis QTL 14 joint integrity trait   (VT:0010548)    
Aia15 Adjuvant induced arthritis QTL 15 joint integrity trait   (VT:0010548)    
Aia16 Adjuvant induced arthritis QTL 16 joint integrity trait   (VT:0010548)    
Aia17 Adjuvant induced arthritis QTL 17 joint integrity trait   (VT:0010548)    
Aia18 Adjuvant induced arthritis QTL 18 joint integrity trait   (VT:0010548)    
Aia19 Adjuvant induced arthritis QTL 19 joint integrity trait   (VT:0010548)    
Aia20 Adjuvant induced arthritis QTL 20 joint integrity trait   (VT:0010548)    
Aia21 Adjuvant induced arthritis QTL 21 joint integrity trait   (VT:0010548)    
Aia22 Adjuvant induced arthritis QTL 22 joint integrity trait   (VT:0010548)    
Aia23 Adjuvant induced arthritis QTL 23 joint integrity trait   (VT:0010548)    
Aia24 Adjuvant induced arthritis QTL 24 joint integrity trait   (VT:0010548)    
Aia25 Adjuvant induced arthritis QTL 25 joint integrity trait   (VT:0010548)    
Aia26 Adjuvant induced arthritis QTL 26 joint integrity trait   (VT:0010548)    
Aia27 Adjuvant induced arthritis QTL 27 joint integrity trait   (VT:0010548)    
Aia6 Adjuvant induced arthritis QTL 6 joint integrity trait   (VT:0010548)    
Aia7 Adjuvant induced arthritis QTL 7 joint integrity trait   (VT:0010548)    
Aia8 Adjuvant induced arthritis QTL 8 joint integrity trait   (VT:0010548)    
Aia9 Adjuvant induced arthritis QTL 9 joint integrity trait   (VT:0010548)    
Cm80 Cardiac mass QTL 80 heart left ventricle mass   (VT:0007031)    
Ginf1 Gastrointestinal inflammation QTL 1 cecum mucosa thickness   (VT:0010234)    
Ginf2 Gastrointestinal inflammation QTL 2 liver integrity trait   (VT:0010547)    
Ginf3 Gastrointestinal inflammation QTL 3 liver integrity trait   (VT:0010547)    
Livw3 Liver weight QTL 3 liver mass   (VT:0003402)    
Wbc3 White blood cell count QTL 3 leukocyte quantity   (VT:0000217)    
Wbc4 White blood cell count QTL 4 leukocyte quantity   (VT:0000217)    
Wbc5 White blood cell count QTL 5 leukocyte quantity   (VT:0000217)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
F344/NCrl (ICL) 631
F344/NCrl (KNAW) 762
F344/NCrl (RGD) 1144
F344/NCrl (2019) 2788
F344/NCrl (2019)


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease 40% restriction of dietary energy comsumption abolishes the development of E2-induced pituitary tumors. 1358973
strain_life_disease 17beta-estradiol induces the development of prolactin(PRL)-producing pituitary tumors and mammary carcinomas. The development of these is tissue specific and is influenced by dietary energy restrictions. 1358973
strain_phys_biochem This strain was used for genotyping candidate single nucleotide polymorphisms; SNPs obtained from this study can be found in NCBI dbSNP under accession numbers ss12535137 - ss12568440, ss12588074 - ss12588105 or Cuppen Group 737879