Strain Report - Rat Genome Database

Name: MWF/Hsd
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: MWF/Hsd
Symbol:	MWF/Hsd
Strain:	MWF
Substrain:	Hsd
Full Name:	Munich Wistar Fromter
RGD ID:	737906
Citation ID:	RRID:RGD_737906
Ontology ID:	RS:0000593
Previously known as:	MDC-03-68; MWF/ZtmHsd
Type:	inbred
Source:	Harlan
Origin:	Substrain of Munich Wistar stock, inbred by Harlan Sprague Dawley
Last Known Status:	Unknown (as of 2020-04-03)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

focal segmental glomerulosclerosis (IAGP)

hypertension (IAGP)

proteinuria (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal cardiovascular system physiology (IAGP)

decreased body weight (IAGP)

decreased cardiac muscle relaxation (IAGP)

decreased erythrocyte cell number (IAGP)

decreased hematocrit (IAGP)

decreased left ventricle systolic pressure (IAGP)

decreased leukocyte cell number (IAGP)

decreased mean systemic arterial blood pressure (IAGP)

glomerulosclerosis (IAGP)

heart right ventricle hypertrophy (IAGP)

increased circulating arginine level (IAGP)

increased circulating cholesterol level (IAGP)

increased circulating triglyceride level (IAGP)

increased prostaglandin level (IAGP)

increased thromboxane level (IAGP)

increased urine flow rate (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

heart rate

left ventricular systolic blood pressure

mean arterial blood pressure

body weight

hematocrit

plasma chloride level

plasma sodium level

plasma potassium level

heart weight to body weight ratio

plasma renin activity level

urine potassium level

urine sodium level

systemic vascular resistance

timed urine volume

food intake rate

plasma total cholesterol level

left ventricular end-diastolic blood pressure

water drink intake rate

urine total protein excretion rate

creatinine clearance

maximum body weight loss to initial body weight ratio

maximum rate of positive change in left ventricular blood pressure

maximum rate of negative change in left ventricular blood pressure

renal vascular resistance

right kidney wet weight to body weight ratio

renal blood flow rate to kidney weight ratio

food intake weight to body weight ratio

lung wet weight to body weight ratio

absolute change in hematocrit

artery tunica media width to artery inner diameter ratio

water intake drink rate to body weight ratio

calculated plasma triglyceride level

central venous pressure

volume of blood removed to total prehemorrhagic blood volume ratio

plasma arginine level

plasma asymmetric dimethylarginine level

plasma arginine level to asymmetric dimethylarginine level ratio

cardiac myocyte cross-sectional area

blood B-type natriuretic peptide level

References

References - curated

#	Reference Title	Reference Citation
1.	Genetic characterization of inbred strains of the rat (Rattus norvegicus).	Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
2.	Sequencing and chromosomal localization of Fabp6 and an intronless Fabp6 segment in the rat.	Bonne A, etal., Mol Biol Rep 2003 Sep;30(3):173-6.
3.	Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants.	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
4.	Institute for Animal Experimentation University of Tokushima School of Medicine	Institute for Animal Experimentation University of Tokushima School of Medicine
5.	Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment.	Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.
6.	Use of simple sequence length polymorphisms for genetic characterization of rat inbred strains.	Otsen M, etal., Mamm Genome 1995 Sep;6(9):595-601.
7.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
8.	SNP and haplotype mapping for genetic analysis in the rat.	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
9.	Genetic variation in coding regions between and within commonly used inbred rat strains.	Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.
10.	Increased cardiovascular risk in rats with primary renal dysfunction; mediating role for vascular endothelial function.	Szymanski MK, etal., Basic Res Cardiol. 2012 Mar;107(2):242. doi: 10.1007/s00395-011-0242-4. Epub 2012 Jan 19.
11.	Proteinuria-associated endothelial dysfunction is strain dependent.	Ulu N, etal., Am J Nephrol. 2009;30(3):209-17. doi: 10.1159/000218062. Epub 2009 May 5.

Region

Damaging Variants

	Number of Damaging Variants
Sample	Rnor_6.0	Rnor_5.0	RGSC_v3.4
MWF/Hsd (2019)	2780
MWF/Hsd (2019)

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_other	These have shorter survival time after controlled hemorrhage than BN/HsdMcwiCrl but longer than DA/OlaHsd.	2302114
strain_phys_biochem	This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203.	737878

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: MWF/Hsd

Mammalian Phenotype

Related Phenotype Data for Term "MWF/Hsd" (RS:0000593)