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Strain: ACI/SegHsd

Symbol: ACI/SegHsd
Strain: ACI
Substrain: SegHsd
RGD ID: 737892
Citation ID: RRID:RGD_737892
Ontology ID: RS:0000032
Previously known as: ACI (#4920); MDC-03-29
Type: inbred
Source: Envigo
Origin: This substrain is derived by Albert Segaloff of the Alton Ochsner Medical Foundation in 1956, now maintained by Harlan Sprague-Dawley, Inc.
Coat Color: Agouti
Last Known Status: Unknown
Research Usage Carcinogenesis; Estrogen-induced pituitary growth; Transplant immunology





Disease Annotations     Click to see Annotation Detail View


Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
mean arterial blood pressure
body weight
hematocrit
liver wet weight
spleen wet weight
both testes wet weight
mammary tumor number
post-insult time to mammary tumor formation
absolute change in thymus weight
prostate gland wet weight
ventral prostate gland wet weight
pituitary gland wet weight
thymus wet weight
prostate tumorous lesion number
area of individual prostate tumorous lesion
area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio
percentage of study population developing unilateral renal agenesis during a period of time
percentage of study population developing ventral prostate tumorous lesions during a period of time
percentage of study population developing mammary tumors during a period of time
percentage of study population developing pituitary tumors during a period of time
percentage of study population developing experimental autoimmune encephalomyelitis during a period of time
percentage of study population developing testis tumors during a period of time
percentage of study population developing bilateral testis tumors during a period of time
percentage of study population developing leukemia during a period of time
percentage of study population developing experimental autoimmune neuritis during a period of time
benign colorectal tumor number
benign colorectal tumor surface area measurement
percentage of study population developing benign colorectal tumors during a period of time
percentage of study population developing poorly differentiated malignant colorectal tumors during a period of time
percentage of study population developing well differentiated malignant colorectal tumors during a period of time
well differentiated malignant colorectal tumor number
well differentiated malignant colorectal tumor surface area measurement
poorly differentiated malignant colorectal tumor surface area measurement
binary logarithm of pituitary gland wet weight
food intake weight to body weight ratio
absolute change in hematocrit
water intake drink rate to body weight ratio
percentage of study population developing subcutaneous tumors during a period of time
volume of blood removed to total prehemorrhagic blood volume ratio
percentage of study population developing ventral prostate tumorous lesions with a solid structure during a period of time
percentage of study population developing ventral prostate tumorous lesions with round, irregular size nuclei during a period of time
area of individual ventral prostate tumorous lesion with a solid structure
area of individual ventral prostate tumorous lesion with round, irregular size nuclei
area of ventral prostate occupied by tumorous lesions with solid structure to total ventral prostate area ratio
area of ventral prostate occupied by tumorous lesions with round, irregular size nuclei to total ventral prostate area ratio
number of ventral prostate tumorous lesions with solid structure
number of ventral prostate tumorous lesions with round, irregular size nuclei

References

References - curated
# Reference Title Reference Citation
1. Genetic characterization of inbred strains of the rat (Rattus norvegicus). Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
2. Sequencing and chromosomal localization of Fabp6 and an intronless Fabp6 segment in the rat. Bonne A, etal., Mol Biol Rep 2003 Sep;30(3):173-6.
3. Identification and chromosome mapping of loci predisposing to colorectal cancer that control Wnt/{beta}-catenin pathway and progression of early lesions in the rat. De Miglio MR, etal., Carcinogenesis. 2007 May 17;.
4. Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18. Gould KA, etal., Genetics 2004 Dec;168(4):2113-25.
5. Genetic mapping of Eutr1, a locus controlling E2-induced pyometritis in the Brown Norway rat, to RNO5. Gould KA, etal., Mamm Genome. 2005 Nov;16(11):854-64. Epub 2005 Nov 11.
6. Genetic mapping of loci controlling diethylstilbestrol-induced thymic atrophy in the Brown Norway rat. Gould KA, etal., Mamm Genome. 2006 May;17(5):451-64.
7. Dietary energy restriction inhibits estrogen-induced mammary, but not pituitary, tumorigenesis in the ACI rat. Harvell DM, etal., Carcinogenesis 2002 Jan;23(1):161-9.
8. Rat strain specific attenuation of estrogen action in the anterior pituitary gland by dietary energy restriction. Harvell DM, etal., Endocrine 2003 Jul;21(2):175-83.
9. Diet-gene interactions in estrogen-induced mammary carcinogenesis in the ACI rat. Harvell DM, etal., J Nutr 2001 Nov;131(11 Suppl):3087S-91S.
10. Rat strain-specific actions of 17beta-estradiol in the mammary gland: correlation between estrogen-induced lobuloalveolar hyperplasia and susceptibility to estrogen-induced mammary cancers. Harvell DM, etal., Proc Natl Acad Sci U S A 2000 Mar 14;97(6):2779-84.
11. Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants. Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
12. Institute for Animal Experimentation University of Tokushima School of Medicine Institute for Animal Experimentation University of Tokushima School of Medicine
13. Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment. Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.
14. Tissue-Specific Actions of the Ept1, Ept2, Ept6, and Ept9 Genetic Determinants of Responsiveness to Estrogens in the Female Rat. Kurz SG, etal., Endocrinology. 2008 Apr 17;.
15. Identification of Two Novel Female-Specific Non-MHC Loci Regulating Collagen-Induced Arthritis Severity and Chronicity, and Evidence for Epistasis. Meng HC,etal., Arthritis Rheum. 2004 Aug;50(8):2695-705.
16. Strains registered by Harlan Laboratories, Inc. Personal communication with Harlan Laboratories
17. RGD Strain RSO annotation pipeline RGD Automated Pipelines
18. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
19. Mapping of three genetic determinants of susceptibility to estrogen-induced mammary cancer within the Emca8 locus on rat chromosome 5. Schaffer BS, etal., Cancer Prev Res (Phila). 2013 Jan;6(1):59-69. doi: 10.1158/1940-6207.CAPR-12-0346-T. Epub 2012 Nov 14.
20. Genetic bases of estrogen-induced tumorigenesis in the rat: mapping of loci controlling susceptibility to mammary cancer in a Brown Norway x ACI intercross. Schaffer BS, etal., Cancer Res. 2006 Aug 1;66(15):7793-800.
21. Ovary-intact, but not ovariectomized female ACI rats treated with 17beta-estradiol rapidly develop mammary carcinoma. Shull JD, etal., Carcinogenesis. 1997 Aug;18(8):1595-601.
22. Susceptibility to estrogen-induced mammary cancer segregates as an incompletely dominant phenotype in reciprocal crosses between the ACI and Copenhagen rat strains. Shull JD, etal., Endocrinology 2001 Dec;142(12):5124-30.
23. Genetic bases of renal agenesis in the ACI rat: mapping of Renag1 to chromosome 14. Shull JD, etal., Mamm Genome. 2006 Jul;17(7):751-9. Epub 2006 Jul 14.
24. Genetic control of estrogen action in the rat: mapping of QTLs that impact pituitary lactotroph hyperplasia in a BN x ACI intercross. Shull JD, etal., Mamm Genome. 2007 Sep 18;.
25. Genetic variation in coding regions between and within commonly used inbred rat strains. Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.
26. Genetic bases of estrogen-induced pituitary growth in an intercross between the ACI and Copenhagen rat strains: dominant mendelian inheritance of the ACI phenotype. Spady TJ, etal., Endocrinology 1999 Jun;140(6):2828-35.
27. Modulation of estrogen action in the rat pituitary and mammary glands by dietary energy consumption. Spady TJ, etal., J Nutr 1999 Feb;129(2S Suppl):587S-590S.
28. Blood pressure and the susceptibility to renal damage after unilateral nephrectomy and L-NAME-induced hypertension in rats. van Dokkum RP, etal., Nephrol Dial Transplant 2000 Sep;15(9):1337-43.
29. Linkage and microarray analyses of susceptibility genes in ACI/Seg rats: a model for prostate cancers in the aged. Yamashita S, etal., Cancer Res 2005 Apr 1;65(7):2610-6.

Region

Strain QTL Data
Symbol Name Trait
Cia25 Collagen induced arthritis QTL 25 joint integrity trait   (VT:0010548)    
Cia26 Collagen induced arthritis QTL 26 joint integrity trait   (VT:0010548)    
Colcr1 Colorectal carcinoma resistance QTL 1 intestine integrity trait   (VT:0010554)    
Colcr2 Colorectal carcinoma resistance QTL 2 intestine integrity trait   (VT:0010554)    
Colcr3 Colorectal carcinoma resistance QTL 3 intestine integrity trait   (VT:0010554)    
Colcr4 Colorectal carcinoma resistance QTL4 intestine integrity trait   (VT:0010554)    
Colcr5 Colorectal carcinoma resistance QTL 5 intestine integrity trait   (VT:0010554)    
Colcr6 Colorectal carcinoma resistance QTL 6 intestine integrity trait   (VT:0010554)    
Colcr7 Colorectal carcinoma resistance QTL 7 intestine integrity trait   (VT:0010554)    
Colcr8 Colorectal carcinoma resistance QTL 8 intestine integrity trait   (VT:0010554)    
Colcr9 Colorectal carcinoma resistance QTL 9 intestine integrity trait   (VT:0010554)    
Colcs1 Colorectal carcinoma susceptibility QTL 1 intestine integrity trait   (VT:0010554)    
Emca1 Estrogen-induced mammary cancer QTL 1 mammary gland integrity trait   (VT:0010552)    
Emca2 Estrogen-induced mammary cancer QTL 2 mammary gland integrity trait   (VT:0010552)    
Emca4 Estrogen-induced mammary cancer QTL 4 mammary gland integrity trait   (VT:0010552)    
Emca5 Estrogen-induced mammary cancer QTL 5 mammary gland integrity trait   (VT:0010552)    
Emca6 Estrogen-induced mammary cancer QTL 6 mammary gland integrity trait   (VT:0010552)    
Emca7 Estrogen-induced mammary cancer QTL 7 mammary gland integrity trait   (VT:0010552)    
Emca8 Estrogen-induced mammary cancer QTL 8 mammary gland integrity trait   (VT:0010552)    
Ept1 Estrogen-induced pituitary tumorigenesis QTL 1 pituitary gland mass   (VT:0010496)    
Ept10 Estrogen-induced pituitary tumorigenesis QTL 10 pituitary gland mass   (VT:0010496)    
Ept13 Estrogen-induced pituitary tumorigenesis QTL 13 pituitary gland mass   (VT:0010496)    
Ept2 Estrogen-induced pituitary tumorigenesis QTL 2 pituitary gland mass   (VT:0010496)    
Ept5 Estrogen-induced pituitary tumorigenesis QTL 5 pituitary gland mass   (VT:0010496)    
Ept6 Estrogen-induced pituitary tumorigenesis QTL 6 pituitary gland mass   (VT:0010496)    
Ept7 Estrogen-induced pituitary tumorigenesis QTL 7 pituitary gland mass   (VT:0010496)    
Ept9 Estrogen-induced pituitary tumorigenesis QTL 9 pituitary gland mass   (VT:0010496)    
Esta1 Estrogen-induced thymic atrophy QTL 1 thymus mass   (VT:0004954)    
Esta2 Estrogen-induced thymic atrophy QTL 2 thymus mass   (VT:0004954)    
Esta3 Estrogen-induced thymic atrophy QTL 3 thymus mass   (VT:0004954)    
Eutr1 Estrogen induced uterine response QTL 1 uterus integrity trait   (VT:0010575)    
Prcr1 Prostate cancer resistance QTL 1 prostate integrity trait   (VT:0010571)    
Prcr2 Prostate cancer resistance QTL 2 prostate integrity trait   (VT:0010571)    
Prcs1 Prostate cancer susceptibility QTL 1 prostate integrity trait   (VT:0010571)    
Prcs2 Prostate cancer susceptibility QTL 2 prostate integrity trait   (VT:0010571)    
Renag1 Renal agenesis QTL 1 kidney development trait   (VT:0000527)    
Tescar1 Testicular tumor resistance QTL 1 testis integrity trait   (VT:0010572)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy ACI rats, both males and females, exhibit unilateral renal agenesis (URA) at an incidence of 5-15% 1580355
strain_drgs_chems Synthetic estrogen diethylstilbestrol (DES) induces pituitary growth in ACI and COP rats and their F1, F2 and backcross progeny. 1358974
strain_drgs_chems DES induces an increase in the circulating PRL in ACI males as compared to COP males. 1358974
strain_drgs_chems These develop three times less severe hypertension and renal damage when given the same dose of L-NAME as compared to FHH/EURMcwi rats. 1357424
strain_drgs_chems 17beta-estradiol stimulates lactotroph proliferation and induces pituitary tumors. 1358974
strain_drgs_chems 17beta-estadiol induces mammary tumorigenesis in females, 100% of the population exhibited palpable mammary tumors. 1358954
strain_drgs_chems resistant to estrogen diethylstilbestrol (DES) induced thymic atrophy in comparison to BN strain 1579780
strain_life_disease These are resistant to collagen-induced arthritis and when mated with DA develop similar disease severity. 1285224
strain_life_disease These are resistant to renal damage. 1357424
strain_life_disease DES induces 2-fold greater growth response in the anterior pituitary gland as compared to COP rats. 1358974
strain_life_disease 17beta-estradiol stimulates mammary cell proliferation and lobuloalveolar hyperplasia. These also exhibit aneuploidy. 1358963
strain_life_disease E2 induced atypical epithelial hyperplasia in the mammary cells which is not present in COP rats. 1358963
strain_life_disease F1, F2 and backcross progeny of these rats with COP show significantly prolonged latency for E2 induced mammary cancer. 1358956
strain_life_disease Susceptibility to E2-induced mammary cancer does not correlate with E2-induced pituitary growth. 1358956
strain_life_disease Dietary energy consumption inhibits mammary carcinogenesis even when the circulating E2 in high. 1358957
strain_life_disease Dietary energy consumption inhibits mammary carcinogenesis even when the circulating E2 in high. 1358973
strain_life_disease spontaneously develop a high incidence of microscopic cancers of the ventral prostate with aging 1358944
strain_life_disease Resistant to estrogen-induced uterine inflammation and infection (pyometritis) 1559292
strain_other DA/BklArb rats have A allele and ACI/SegHsd have a G allele at nucleotide 316 (codon 106) and DA/BklArb rats have T allele and ACI/SegHsd have a C allele at nucleotide 458 (codon 153) that cause amino acid change which is responsible for arthritis-susceptible and resistant SNPs that correlated with variable production of reactive oxygen species 1285224
strain_other 12 weeks of E2 treatment in females exhibit an increase in pituitary weight and circulating PRL. 1358963
strain_other E2-induced mammary carcinogenesis is mapped to rat chromosome 5 to the Emca1 region which has the Cdkn2a tumor suppressor gene. 1358957
strain_other These have shorter survival time after controlled hemorrhage than BN/HsdMcwiCrl but longer than DA/OlaHsd. 2302114
strain_phys_biochem This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203. 737878
strain_phys_biochem Dietary energy restrictions inhibit mammary tumorigenesis which is tissue specific and is independent of circulating E2 and prolactin-producing pituitary tumors. 1358954

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-12 ACI/SegHsd    ACI/SegHsd    Name updated 68913 APPROVED
2015-10-12 ACI/SegHsd    ACI/SegHsd    Name updated 68913 APPROVED
2015-10-12 ACI/SegHsd    ACI/SegHsd    Name updated 68913 APPROVED
2015-10-12 ACI/SegHsd    ACI/SegHsd    Name updated 68913 APPROVED
2014-09-25 ACI/SegHsd    ACI/SegHsd    Name updated 68913 APPROVED
2014-09-25 ACI/SegHsd    ACI/SegHsd    Name updated 68913 APPROVED