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Strain: Crl:SD

Symbol: Crl:SD
Strain: SD
Substrain: Crl
RGD ID: 737891
Citation ID: RRID:RGD_737891
Ontology ID: RS:0000695
Also Known As: SD/Crl
Type: outbred
Available Source: Charles River Laboratories, Inc., Wilmington, MA
Description: Sprague-Dawley stock initiated by R. Dawley in 1925; To SASCO from ARS/Sprague Dawley in 1979. To Charles River in 1996 now maintained by Charles River Laboratory.
Last Known Status: Unknown

Disease Annotations     Click to see Annotation Detail View
Toxemia  (IAGP)

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
systolic blood pressure
mean arterial blood pressure
body weight
plasma glucose level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
blood glucose level
plasma albumin level
serum creatinine level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
plasma calcium level
liver weight
both kidneys wet weight to body weight ratio
plasma insulin level
serum total cholesterol level
serum total bilirubin level
body weight gain
food intake rate
plasma creatinine level
serum glucose level
plasma triglyceride level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
plasma total cholesterol level
plasma urea nitrogen level
serum urea nitrogen level
liver weight to body weight ratio
water drink intake rate
urine total protein excretion rate
plasma glucagon level
maximum body weight loss to initial body weight ratio
ethanol drink intake rate
liver cholesterol level
brain cholesterol level
brain phytosterol level
brain campesterol level
brain sitosterol level
liver sitosterol level
liver campesterol level
liver phytosterol level
plasma sitosterol level
plasma campesterol level
plasma phytosterol level
food calorie intake rate
total body fat volume
whole body subcutaneous fat volume
whole body visceral fat volume
whole body lean tissue volume
liver fat volume to total liver volume ratio
left renal fat pad weight
left renal fat pad weight to body weight ratio
fructose drink intake rate
bisphenol A in fructose drink intake rate
food intake weight to body weight ratio
plasma gamma-glutamyltransferase activity level
kidney glomerulus volume
fructose drink calorie intake rate
total calorie intake rate
plasma total bilirubin level
plasma globulin level
metformin drink intake rate
absolute change in hematocrit
water intake drink rate to body weight ratio
plasma osmolality
number of podocytes per kidney glomerulus
volume of blood removed to total prehemorrhagic blood volume ratio


References - curated
# Reference Title Reference Citation
1. Single Nucleotide Polymorphisms associated with rat expressed sequences. Guryev V, etal., Genome Res. 2004 Jul;14(7):1438-43.
2. Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment. Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.
3. Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1. Newman ZL, etal., PLoS Pathog. 2010 May 20;6(5):e1000906. doi: 10.1371/journal.ppat.1000906.
4. Strains registered by Charles River Laboratories International, Inc. Personal communication with Charles River Laboratories
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Effect of Chronic Blockade of the Kallikrein-Kinin System on the Development of Hypertension in Rats. Rhaleb NE, etal., Hypertension 2001 Jan;37(1):121-128.
7. Bisphenol A exposure increases liver fat in juvenile fructose-fed Fischer 344 rats. Ronn M, etal., Toxicology. 2013 Jan 7;303:125-32. doi: 10.1016/j.tox.2012.09.013. Epub 2012 Nov 8.
8. Genetic variation in coding regions between and within commonly used inbred rat strains. Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.
9. Hypernatremia-induced vasopressin secretion is not altered in TRPV1-/- rats. Tucker AB and Stocker SD, Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R451-6. doi: 10.1152/ajpregu.00483.2015. Epub 2016 Jun 22.
10. Antihypertensive effects of metformin in fructose-fed hyperinsulinemic, hypertensive rats. Verma S, etal., J Pharmacol Exp Ther. 1994 Dec;271(3):1334-7.
11. Renal protective effect of angiotensin-converting enzyme inhibition in aging rats. Zoja C, etal., Am J Med. 1992 Apr 27;92(4B):60S-63S. doi: 10.1016/0002-9343(92)90149-6.


Strain Samples in RGD with Damaging Variants (Polyphen)
Rnor_5.0 Crl:SD (UDEL) View Damaging Variants

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other These have shorter survival time after controlled hemorrhage than BN/HsdMcwiCrl but longer than DA/OlaHsd. 2302114
strain_phys_biochem This strain was used for genotyping candidate single nucleotide polymorphisms; SNPs obtained from this study can be found in NCBI dbSNP under accession numbers ss12535137 - ss12568440, ss12588074 - ss12588105 or Cuppen Group 737879