Strain Report - Rat Genome Database

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Strain: DA.E3-(D12Got46-D12Rat26)/Rhd

Symbol: DA.E3-(D12Got46-D12Rat26)/Rhd
Strain: DA.E3-(D12Got46-D12Rat26)
Substrain: Rhd
RGD ID: 737871
Citation ID: RRID:RGD_737871
Ontology ID: RS:0000203
Previously known as: DA.Ncf1E3; DA.Pia4; DA.E3-(D12Got46-D12Rat26)/Rhd
Type: congenic
Source: Section for Medical Inflammation Research, Lund University, Lund, Sweden.
Origin: This congenic strain was obtained by the conventional backcross breeding to the parental DA strain with the negative selection of all known Pia QTLs and positive selection of microsatellite markers.
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,297,209 - 22,692,658RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01225,307,118 - 29,014,362RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01227,316,608 - 30,964,880RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41223,362,298 - 23,845,733RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. Arthritis suppression by NADPH activation operates through an interferon-beta pathway. Olofsson P, etal., BMC Biol. 2007 May 9;5(1):19.
2. Identification and isolation of dominant susceptibility loci for pristane-induced arthritis. Olofsson P, etal., J Immunol 2003 Jul 1;171(1):407-16.
3. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Olofsson P, etal., Nat Genet 2003 Jan;33(1):25-32.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Position Markers

Flank 1 / 1 (D12Got46)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21222,297,209 - 22,297,425 (+)MAPPER
Rnor_6.01229,014,147 - 29,014,362NCBI
Rnor_6.01225,307,118 - 25,307,333NCBI
Rnor_5.01230,964,665 - 30,964,880UniSTS
Rnor_5.01227,316,608 - 27,316,823UniSTS
RGSC_v3.41223,362,298 - 23,362,514RGD
RGSC_v3.41223,362,299 - 23,362,514UniSTS
RGSC_v3.11223,225,514 - 23,225,729RGD
Celera1224,060,262 - 24,060,477UniSTS
RH 3.4 Map12351.3UniSTS
RH 3.4 Map12351.3RGD
RH 2.0 Map12238.9RGD
Cytogenetic Map12q12UniSTS

Flank 2 / 1 (D12Rat26)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21222,692,481 - 22,692,658 (+)MAPPER
Rnor_6.01225,711,448 - 25,711,626NCBI
Rnor_5.01227,718,806 - 27,718,984UniSTS
RGSC_v3.41223,845,555 - 23,845,733UniSTS
RGSC_v3.41223,845,554 - 23,845,733RGD
RGSC_v3.11223,708,770 - 23,708,949RGD
Celera1224,451,694 - 24,451,872UniSTS
SHRSP x BN Map1225.79UniSTS
SHRSP x BN Map1225.79RGD
FHH x ACI Map1211.22RGD
Strain QTL Data
Symbol Name Trait
Pia22 Pristane induced arthritis QTL 22 joint integrity trait   (VT:0010548)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease One Pia4 allele showed 80% less severe arthritis and two alleles showed 90% less sever arthritis by linkage analysis 631850