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Strain: PVG.1AV1

Symbol: PVG.1AV1
Strain: PVG.1AV1
Full Name: Piebald-Virol-Glaxo
RGD ID: 737658
Citation ID: RRID:RGD_737658
Ontology ID: RS:0000644
Also Known As: PVG.RT1a; PVG.RT1a; PVG.AV1; Piebald-Viral-Glaxo
Type: congenic
Available Source: Harlan UK, Blackthorn, Bicester, UK
Description: Originally derived by Dr. Hans J. Hendrich at Versuchstierzucht, Hannover, Germany
Last Known Status: Unknown


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. Mapping and functional characterization of rat chromosome 4 regions that regulate arthritis models and phenotypes in congenic strains. Backdahl L, etal., Arthritis Rheum 2003 Feb;48(2):551-9.
2. New loci regulating rat myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Becanovic K, etal., J Immunol 2003 Jan 15;170(2):1062-9.
3. Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern. Dahlman I, etal., Eur J Immunol 1998 Jul;28(7):2188-96
4. MHC and non-MHC gene regulation of disease susceptibility and disease course in experimental inflammatory peripheral neuropathy. de Graaf KL, etal., J Neuroimmunol. 2004 Oct;155(1-2):73-84.
5. An advanced intercross line resolves Eae18 into two narrow quantitative trait loci syntenic to multiple sclerosis candidate loci. Jagodic M, etal., J Immunol 2004 Jul 15;173(2):1366-73.
6. Resolution of a 16.8-Mb autoimmunity-regulating rat chromosome 4 region into multiple encephalomyelitis quantitative trait loci and evidence for epistasis. Jagodic M, etal., J Immunol 2005 Jan 15;174(2):918-24.
7. Susceptibility to oil-induced arthritis is linked to Oia2 on chromosome 4 in a DA(DA x PVG.1AV1) backcross. Jansson AM, etal., Transplant Proc 1999 May;31(3):1597-9.
8. Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS. Lidman O, etal., J Neurosci 2003 Oct 29;23(30):9817-23.
9. Association of arthritis with a gene complex encoding C-type lectin-like receptors. Lorentzen JC, etal., Arthritis Rheum. 2007 Aug;56(8):2620-32.
10. Definition of a 1.06-Mb region linked to neuroinflammation in humans, rats and mice. Ockinger J, etal., Genetics. 2006 Jul;173(3):1539-45. Epub 2006 Apr 19.
11. RGD Strain RSO annotation pipeline RGD Automated Pipelines
12. Eae19, a new locus on rat chromosome 15 regulating experimental autoimmune encephalomyelitis. Sheng JR, etal., Genetics 2005 May;170(1):283-9. Epub 2005 Feb 16.
13. MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. Swanberg M, etal., Nat Genet 2005 May;37(5):486-94. Epub 2005 Apr 10.


Strain QTL Data
Symbol Name Trait
Eae16 Experimental allergic encephalomyelitis QTL 16 nervous system integrity trait   (VT:0010566)    
Eae17 Experimental allergic encephalomyelitis QTL 17 nervous system integrity trait   (VT:0010566)    
Eae19 Experimental allergic encephalomyelitis QTL 19 nervous system integrity trait   (VT:0010566)    
Eae20 Experimental allergic encephalomyelitis QTL 20 nervous system integrity trait   (VT:0010566)    
Eae21 Experimental allergic encephalomyelitis QTL 21 body mass   (VT:0001259)    
Eae22 Experimental allergic encephalomyelitis QTL 22 nervous system integrity trait   (VT:0010566)    
Neuinf3 Neuroinflammation QTL 3 nervous system integrity trait   (VT:0010566)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Resistant to experimental induction of arthritis. 629560
strain_life_disease When injected with mineral oil incomplete Freund's adjuvant (IFA) these animals didnot develop arthritis. The F1 progeny when crossed with DA were also resistant whereas 4% of F2 and 46%of DA(DA x PVG.1AV1) backcross had signs of arthritis. 737700
strain_other The genome of this strain depicts more arthritis resistance than that of LEW.1AV1 737700
strain_other The F7 generation of a DA x PVG.1AV1 intercross were used for myelin oligodendrocyte glycoprotein-induced experimental allergic encephalomyelitis QTL mapping. 1302437

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-21 PVG.1AV1  Piebald-Virol-Glaxo  PVG.1AV1  Piebald-Viral-Glaxo  Symbol and/or name change 68913 APPROVED