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Strain: PVG.1AV1

Symbol: PVG.1AV1
Strain: PVG.1AV1
Full Name: Piebald-Virol-Glaxo
RGD ID: 737658
Citation ID: RRID:RGD_737658
Ontology ID: RS:0000644
Previously known as: PVG.RT1a; PVG.RT1a; PVG.AV1; Piebald-Viral-Glaxo
Type: congenic
Source: Harlan UK, Blackthorn, Bicester, UK
Origin: Originally derived by Dr. Hans J. Hendrich at Versuchstierzucht, Hannover, Germany
Last Known Status: Unknown


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. Mapping and functional characterization of rat chromosome 4 regions that regulate arthritis models and phenotypes in congenic strains. Backdahl L, etal., Arthritis Rheum 2003 Feb;48(2):551-9.
2. Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern. Dahlman I, etal., Eur J Immunol 1998 Jul;28(7):2188-96
3. MHC and non-MHC gene regulation of disease susceptibility and disease course in experimental inflammatory peripheral neuropathy. de Graaf KL, etal., J Neuroimmunol. 2004 Oct;155(1-2):73-84.
4. An advanced intercross line resolves Eae18 into two narrow quantitative trait loci syntenic to multiple sclerosis candidate loci. Jagodic M, etal., J Immunol 2004 Jul 15;173(2):1366-73.
5. Susceptibility to oil-induced arthritis is linked to Oia2 on chromosome 4 in a DA(DA x PVG.1AV1) backcross. Jansson AM, etal., Transplant Proc 1999 May;31(3):1597-9.
6. Association of arthritis with a gene complex encoding C-type lectin-like receptors. Lorentzen JC, etal., Arthritis Rheum. 2007 Aug;56(8):2620-32.
7. Definition of a 1.06-Mb region linked to neuroinflammation in humans, rats and mice. Ockinger J, etal., Genetics. 2006 Jul;173(3):1539-45. Epub 2006 Apr 19.
8. RGD Strain RSO annotation pipeline RGD Automated Pipelines
9. MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction. Swanberg M, etal., Nat Genet 2005 May;37(5):486-94. Epub 2005 Apr 10.


Strain QTL Data
Symbol Name Trait
Eae16 Experimental allergic encephalomyelitis QTL 16 nervous system integrity trait   (VT:0010566)    
Eae17 Experimental allergic encephalomyelitis QTL 17 nervous system integrity trait   (VT:0010566)    
Eae19 Experimental allergic encephalomyelitis QTL 19 nervous system integrity trait   (VT:0010566)    
Eae20 Experimental allergic encephalomyelitis QTL 20 nervous system integrity trait   (VT:0010566)    
Eae21 Experimental allergic encephalomyelitis QTL 21 body mass   (VT:0001259)    
Eae22 Experimental allergic encephalomyelitis QTL 22 nervous system integrity trait   (VT:0010566)    
Neuinf3 Neuroinflammation QTL 3 nervous system integrity trait   (VT:0010566)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Resistant to experimental induction of arthritis. 629560
strain_life_disease When injected with mineral oil incomplete Freund's adjuvant (IFA) these animals didnot develop arthritis. The F1 progeny when crossed with DA were also resistant whereas 4% of F2 and 46%of DA(DA x PVG.1AV1) backcross had signs of arthritis. 737700
strain_other The genome of this strain depicts more arthritis resistance than that of LEW.1AV1 737700
strain_other The F7 generation of a DA x PVG.1AV1 intercross were used for myelin oligodendrocyte glycoprotein-induced experimental allergic encephalomyelitis QTL mapping. 1302437

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-21 PVG.1AV1  Piebald-Virol-Glaxo  PVG.1AV1  Piebald-Viral-Glaxo  Symbol and/or name change 68913 APPROVED