Strain: OLETF.F344-(D1Rat306-D1Rat461 )/Got
Symbol:
OLETF.F344-(D1Rat306-D1Rat461 )/Got
Strain:
OLETF.F344-(D1Rat306-D1Rat461 )
Substrain:
Got
RGD ID:
734531
Citation ID:
RRID:RGD_734531
Ontology ID:
RS:0000627
Previously known as:
BC4:F2; OLETF.F344-(D1Rat306-D1Rat461)/Got
Type:
congenic
Source:
Otsuka Pharmacuetical Company, 463-10 Kagasuno, Tokushima, Japan
Origin:
Female OLETF/Got rats were crossed with F344/DuCrlj rats. The F1 were backcrossed to OLETF to produce the BC1. Selective males from BC1 were backcrossed to OLETF to produce successive congenic generations. Fourth generation backcrossed congenic animals were intercrossed to produce the F2 generation.
Last Known Status:
Unknown
Position
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 1 258,843,780 - 258,843,987 RGD_MAPPER_PIPELINE mRatBN7.2 Rnor_6.0 1 280,850,604 - 280,850,810 RGD_MAPPER_PIPELINE Rnor6.0 Rnor_5.0 1 268,967,725 - 288,207,792 RGD_MAPPER_PIPELINE Rnor5.0 RGSC_v3.4 1 248,583,506 - 266,234,812 RGD_MAPPER_PIPELINE RGSC3.4
References
Region
Position Markers
Flank 1 / 1 (D1Rat306 )
Rat Assembly Chr Position (strand) Source Rnor_5.0 1 268,967,725 - 268,967,859 NCBI RGSC_v3.4 1 248,583,506 - 248,583,639 RGD RGSC_v3.1 1 248,843,278 - 248,843,684 RGD SHRSP x BN Map 1 135.6499 RGD SHRSP x BN Map 1 135.6499 UniSTS
Flank 2 / 1 (D1Rat461 )
Rat Assembly Chr Position (strand) Source mRatBN7.2 1 258,843,780 - 258,843,987 (+) MAPPER Rnor_6.0 1 280,850,604 - 280,850,810 NCBI Rnor_5.0 1 288,207,586 - 288,207,792 UniSTS RGSC_v3.4 1 266,234,606 - 266,234,812 UniSTS RGSC_v3.4 1 266,234,605 - 266,234,810 RGD RGSC_v3.1 1 266,445,650 - 266,445,855 RGD Celera 1 254,492,059 - 254,492,265 UniSTS RH 3.4 Map 1 1697.9 UniSTS RH 3.4 Map 1 1697.9 RGD RH 2.0 Map 1 1322.8999 RGD SHRSP x BN Map 1 149.25 RGD
Strain QTL Data
Symbol
Name
Trait
Niddm59
Non-insulin dependent diabetes mellitus QTL 59
body mass (VT:0001259)
Additional Information
RGD Curation Notes
Note Type
Note
Reference
strain_characteristics
In this congenic strain both OLETF alleles have been replaced by F344-derived alleles.
734465
strain_phys_biochem
Body weight, abdominal fat weight, serum triacylglycerols, total cholesterol, food consumption and blood glucose showed a significant decrease as compared to the parents.
734465