Strain Report - Rat Genome Database

Name: OLETF.F344-( D1Rat306-D1Rat461 )/Got
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: OLETF.F344-(D1Rat306-D1Rat461)/Got

Symbol:

OLETF.F344-(D1Rat306-D1Rat461)/Got

Strain:

OLETF.F344-(D1Rat306-D1Rat461)

Substrain:

Got

RGD ID:

734531

Citation ID:

RRID:RGD_734531

Ontology ID:

RS:0000627

Previously known as:

BC4:F2; OLETF.F344-(D1Rat306-D1Rat461)/Got

Type:

congenic

Source:

Otsuka Pharmacuetical Company, 463-10 Kagasuno, Tokushima, Japan

Origin:

Female OLETF/Got rats were crossed with F344/DuCrlj rats. The F1 were backcrossed to OLETF to produce the BC1. Selective males from BC1 were backcrossed to OLETF to produce successive congenic generations. Fourth generation backcrossed congenic animals were intercrossed to produce the F2 generation.

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	258,843,780 - 258,843,987	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	1	280,850,604 - 280,850,810	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	1	268,967,725 - 288,207,792	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	1	248,583,506 - 266,234,812	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased abdominal fat pad weight (IAGP)

decreased body length (IAGP)

decreased body mass index (IAGP)

decreased body weight (IAGP)

decreased circulating cholesterol level (IAGP)

decreased circulating triglyceride level (IAGP)

decreased food intake (IAGP)

decreased glycosylated hemoglobin level (IAGP)

decreased liver weight (IAGP)

decreased mesenteric fat pad weight (IAGP)

improved glucose tolerance (IAGP)

increased brain weight (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF rats.	Okuno S, etal., Diabetes Obes Metab 2002 Sep;4(5):309-18.
2.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D1Rat306)

Rat Assembly	Chr	Position (strand)	Source
Rnor_5.0	1	268,967,725 - 268,967,859	NCBI
RGSC_v3.4	1	248,583,506 - 248,583,639	RGD
RGSC_v3.1	1	248,843,278 - 248,843,684	RGD
SHRSP x BN Map	1	135.6499	RGD
SHRSP x BN Map	1	135.6499	UniSTS

Flank 2 / 1 (D1Rat461)

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	258,843,780 - 258,843,987 (+)	MAPPER
Rnor_6.0	1	280,850,604 - 280,850,810	NCBI
Rnor_5.0	1	288,207,586 - 288,207,792	UniSTS
RGSC_v3.4	1	266,234,606 - 266,234,812	UniSTS
RGSC_v3.4	1	266,234,605 - 266,234,810	RGD
RGSC_v3.1	1	266,445,650 - 266,445,855	RGD
Celera	1	254,492,059 - 254,492,265	UniSTS
RH 3.4 Map	1	1697.9	UniSTS
RH 3.4 Map	1	1697.9	RGD
RH 2.0 Map	1	1322.8999	RGD
SHRSP x BN Map	1	149.25	RGD

Strain QTL Data

Symbol	Name	Trait
Niddm59	Non-insulin dependent diabetes mellitus QTL 59	body mass (VT:0001259)

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_characteristics	In this congenic strain both OLETF alleles have been replaced by F344-derived alleles.	734465
strain_phys_biochem	Body weight, abdominal fat weight, serum triacylglycerols, total cholesterol, food consumption and blood glucose showed a significant decrease as compared to the parents.	734465

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: OLETF.F344-(D1Rat306-D1Rat461)/Got

Mammalian Phenotype