Strain Report - Rat Genome Database

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Strain: OLETF.F344-(D1Rat306-D1Rat461)/Got

Symbol: OLETF.F344-(D1Rat306-D1Rat461)/Got
Strain: OLETF.F344-(D1Rat306-D1Rat461)
Substrain: Got
RGD ID: 734531
Citation ID: RRID:RGD_734531
Ontology ID: RS:0000627
Also Known As: BC4:F2; OLETF.F344-(D1Rat306-D1Rat461)/Got
Type: congenic
Available Source: Not Available
Origination: Otsuka Pharmacuetical Company, 463-10 Kagasuno, Tokushima, Japan
Description: Female OLETF/Got rats were crossed with F344/DuCrlj rats. The F1 were backcrossed to OLETF to produce the BC1. Selective males from BC1 were backcrossed to OLETF to produce successive congenic generations. Fourth generation backcrossed congenic animals were intercrossed to produce the F2 generation.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21258,843,780 - 258,843,987RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01280,850,604 - 280,850,810RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01268,967,725 - 288,207,792RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41248,583,506 - 266,234,812RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Substitution of Dmo1 with normal alleles results in decreased manifestation of diabetes in OLETF rats. Okuno S, etal., Diabetes Obes Metab 2002 Sep;4(5):309-18.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D1Rat306)
Rat AssemblyChrPosition (strand)Source
Rnor_5.01268,967,725 - 268,967,859NCBI
RGSC_v3.41248,583,506 - 248,583,639RGD
RGSC_v3.11248,843,278 - 248,843,684RGD
SHRSP x BN Map1135.6499RGD
SHRSP x BN Map1135.6499UniSTS

Flank 2 / 1 (D1Rat461)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21258,843,780 - 258,843,987 (+)MAPPER
Rnor_6.01280,850,604 - 280,850,810NCBI
Rnor_5.01288,207,586 - 288,207,792UniSTS
RGSC_v3.41266,234,606 - 266,234,812UniSTS
RGSC_v3.41266,234,605 - 266,234,810RGD
RGSC_v3.11266,445,650 - 266,445,855RGD
Celera1254,492,059 - 254,492,265UniSTS
RH 3.4 Map11697.9UniSTS
RH 3.4 Map11697.9RGD
RH 2.0 Map11322.8999RGD
SHRSP x BN Map1149.25RGD
Strain QTL Data
Symbol Name Trait
Niddm59 Non-insulin dependent diabetes mellitus QTL 59 body mass   (VT:0001259)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics In this congenic strain both OLETF alleles have been replaced by F344-derived alleles. 734465
strain_phys_biochem Body weight, abdominal fat weight, serum triacylglycerols, total cholesterol, food consumption and blood glucose showed a significant decrease as compared to the parents. 734465