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Strain Registration

Strain: OLETF/Got

Symbol: OLETF/Got
Strain: OLETF
Substrain: Got
Full Name: Otsuka Long Evans Tokushima
RGD ID: 734526
Citation ID: RRID:RGD_734526
Ontology ID: RS:0000625
Previously known as: OLETF/Otk
Type: inbred
Source: Otsuka Pharmacuetical Company, 463-10 Kagasuno, Tokushima, Japan
Origin: Long Evans Charles River Canada introduced it to Otsuka Pharmaceutical Co. in 1982. This is selectively bred by oral glucose tolerance test of selective brother-sister mating.
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Kose H, etal., Mamm Genome 2002 Oct;13(10):558-62.
2. Identification of a quantitative trait locus influencing plasma insulin levels after 70% pancreatectomy using the OLETF rat. Moralejo DH, etal., J Vet Med Sci 1998 Oct;60(10):1157-60.
3. A major quantitative trait locus co-localizing with cholecystokinin type A receptor gene influences poor pancreatic proliferation in a spontaneously diabetogenic rat. Moralejo DH, etal., Mamm Genome 1998 Oct;9(10):794-8.
4. Identification of quantitative trait loci for non-insulin-dependent diabetes mellitus that interact with body weight in the Otsuka Long-Evans Tokushima Fatty rat. Moralejo DH, etal., Proc Assoc Am Physicians 1998 Nov-Dec;110(6):545-58.
5. Pnlip encoding pancreatic lipase is possible candidate for obesity QTL in the OLETF rat. Muramatsu Y, etal., Biochem Biophys Res Commun 2005 Jun 17;331(4):1270-6.
6. Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF. Ogino T, etal., Genomics 2000 Nov 15;70(1):19-25.
7. Effects of Dmo1 on obesity, dyslipidaemia and hyperglycaemia in the Otsuka Long Evans Tokushima Fatty strain. Okuno S, etal., Genet Res 2001 Apr;77(2):183-90.
8. RGD Strain RSO annotation pipeline RGD Automated Pipelines
9. Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima fatty rat by MQM-mapping method. Sugiura K, etal., Mamm Genome 1999 Dec;10(12):1126-31.
10. Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat. Wei S, etal., Mamm Genome 1999 Mar;10(3):249-58
11. Identification of epistatic interactions involved in non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat. Yamada T, etal., Exp Anim 2001 Apr;50(2):115-23.
12. Quantitative trait loci for lipid metabolism in the study of OLETF x (OLETF x Fischer 344) backcross rats. Yamasaki Y, etal., Clin Exp Pharmacol Physiol 2000 Nov;27(11):881-6.

Region

Strain QTL Data
Symbol Name Trait
Bw21 Body weight QTL 21 body mass   (VT:0001259)    
Insul2 Insulin level QTL 2 blood insulin amount   (VT:0001560)    
Niddm20 Non-insulin dependent diabetes mellitus QTL 20 blood glucose amount   (VT:0000188)    
Niddm21 Non-insulin dependent diabetes mellitus QTL 21 blood glucose amount   (VT:0000188)    
Niddm22 Non-insulin dependent diabetes mellitus QTL 22 blood glucose amount   (VT:0000188)    
Niddm23 Non-insulin dependent diabetes mellitus QTL 23 blood glucose amount   (VT:0000188)    
Niddm24 Non-insulin dependent diabetes mellitus QTL 24 blood glucose amount   (VT:0000188)    
Niddm25 Non-insulin dependent diabetes mellitus QTL 25 blood glucose amount   (VT:0000188)    
Niddm26 Non-insulin dependent diabetes mellitus QTL 26 blood glucose amount   (VT:0000188)    
Niddm27 Non-insulin dependent diabetes mellitus QTL 27 blood glucose amount   (VT:0000188)    
Niddm28 Non-insulin dependent diabetes mellitus QTL 28 blood glucose amount   (VT:0000188)    
Niddm29 Non-insulin dependent diabetes mellitus QTL 29 blood glucose amount   (VT:0000188)    
Niddm30 Non-insulin dependent diabetes mellitus QTL 30 blood glucose amount   (VT:0000188)    
Niddm31 Non-insulin dependent diabetes mellitus QTL 31 blood glucose amount   (VT:0000188)    
Niddm32 Non-insulin dependent diabetes mellitus QTL 32 blood glucose amount   (VT:0000188)    
Niddm52 Non-insulin dependent diabetes mellitus QTL 52 blood glucose amount   (VT:0000188)    
Niddm53 Non-insulin dependent diabetes mellitus QTL 53 blood glucose amount   (VT:0000188)    
Niddm54 Non-insulin dependent diabetes mellitus QTL 54 blood glucose amount   (VT:0000188)    
Niddm55 Non-insulin dependent diabetes mellitus QTL 55 blood glucose amount   (VT:0000188)    
Niddm56 Non-insulin dependent diabetes mellitus QTL 56 blood glucose amount   (VT:0000188)    
Pancm5 Pancreatic morphology QTL 5 pancreas mass   (VT:0010144)    
Scl67 Serum cholesterol level QTL 67 blood cholesterol amount   (VT:0000180)    
Stl31 Serum triglyceride level QTL 31 blood triglyceride amount   (VT:0002644)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Female rats are not diabetic unless forced to be obese. 619683
strain_life_disease A model for noninsulin-dependent diabetes mellitus (NIDDM). 619679
strain_life_disease Develops late onset of hyperglycemia, hyperinsulinemia,hypertriglyceridaemia. Has insulin resistance and abundant visceral fat. 619679

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-13 OLETF/Got    OLETF/Otk    Data Merged 737654 APPROVED