Strain Report - Rat Genome Database

Name: Crl:CD(SD)
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: Crl:CD(SD)
Symbol:	Crl:CD(SD)
Strain:	CD(SD)
Substrain:	Crl
RGD ID:	734476
Citation ID:	RRID:RGD_734476
Ontology ID:	RS:0000064
Previously known as:	Crl:CD.(SD)IGSBR; CD^??IGS; Crl:CD(SD)IGS; CDIGS; CD. IGS; Crl:CD*(SD)IGSBR
Type:	outbred
Source:	Charles River Laboratories
Origin:	Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. To CRL in 1950 from Sprague Dawley, Inc. Caesarean rederived in 1955 from original Charles River Sprague Dawley. colonies. In 1991, 8 colonies were selected to form the IGS Foundation Colony. Rederived into isolator foundation colony in 1997. IGS refers to animals bred using the CRL International Genetic Standard system.
Coat Color:	Albino
Last Known Status:	Unknown

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Mammary Neoplasms (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

increased circulating insulin level (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

heart rate

left ventricular diastolic blood pressure

left ventricular systolic blood pressure

mean arterial blood pressure

body weight

body temperature

left ventricular developed pressure

red blood cell count

blood hemoglobin level

blood neutrophil count

blood lymphocyte count

blood monocyte count

blood eosinophil count

hematocrit

mean corpuscular volume

plasma glucose level

plasma aspartate aminotransferase activity level

plasma alanine aminotransferase activity level

blood urea nitrogen level

serum creatinine level

plasma anion gap

heart wet weight

heart weight to body weight ratio

lung dry weight to body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

minute ventilation

liver wet weight

arterial blood flow rate

tidal volume

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin

mean corpuscular hemoglobin concentration

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

mammary tumor number

post-insult time to mammary tumor formation

serum total cholesterol level

total white blood cell count

serum total bilirubin level

blood pH

partial pressure of blood oxygen

food intake rate

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

absolute change in mean arterial blood pressure

absolute change in heart rate

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum estradiol level

serum progesterone level

plasma angiotensin II level

serum alanine aminotransferase activity level

serum alkaline phosphatase activity level

serum aspartate aminotransferase activity level

serum urea nitrogen level

plasma high density lipoprotein cholesterol level

plasma low density lipoprotein cholesterol level

plasma very low density lipoprotein cholesterol level

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight to total heart left ventricle weight ratio

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

dose of methacholine at which pulmonary conductance is half its pretreatment value

fractional change in blood vessel diameter per unit change in intravascular pressure

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricular developed pressure

percent change in left ventricular systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

urine creatinine excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

plasma lactate level

food intake weight to body weight ratio

serum globulin level

plasma pyruvate level

urine creatine excretion rate

urine taurine excretion rate

plasma acetaminophen level

plasma acetaminophen level area under curve

plasma glutamate dehydrogenase activity level

liver oxidized glutathione level to liver weight ratio

liver reduced glutathione level to liver weight ratio

urine protein level to urine creatinine level ratio

plasma AMG-8718 level area under curve (AUC)

plasma AMG-8718 maximum concentration

full retina thickness

retinal outer layer thickness

retinal inner layer thickness

retinal outer nuclear layer photoreceptor nucleus count

retinal outer nuclear layer thickness

References

References - curated

#	Reference Title	Reference Citation
1.	Oral exposure to bisphenol a increases dimethylbenzanthracene-induced mammary cancer in rats.	Jenkins S, etal., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7.
2.	Role of genetic modifiers in an orthologous rat model of ARPKD.	O'Meara CC, etal., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5.
3.	The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass.	Paglialunga S, etal., Appl Physiol Nutr Metab. 2017 Jun;42(6):647-655. doi: 10.1139/apnm-2016-0585. Epub 2017 Jan 31.
4.	Strains registered by Charles River Laboratories International, Inc.	Personal communication with Charles River Laboratories
5.	PhysGen Strains	PhysGen strains
6.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_life_disease	The blood pressure of females is 110 mmHg and of males is 120 mmHg.	629526
strain_other	The average weight of females is 231g and of males 388g.	629526

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-01-22	Crl:CD(SD)		Crl:CD(SD)		Name updated	68913	APPROVED
2015-01-22	Crl:CD(SD)		Crl:CD(SD)		Name updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: Crl:CD(SD)

Mammalian Phenotype

Related Phenotype Data for Term "Crl:CD(SD)" (RS:0000064)