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Strain: Crl:CD(SD)

Symbol: Crl:CD(SD)
Strain: CD(SD)
Substrain: Crl
RGD ID: 734476
Citation ID: RRID:RGD_734476
Ontology ID: RS:0000064
Also Known As: Crl:CD.(SD)IGSBR; CD??IGS; Crl:CD(SD)IGS; CDIGS; CD. IGS; Crl:CD*(SD)IGSBR
Type: outbred
Available Source: Charles River Laboratories
Origination: Charles River Laboratories
Description: Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. To CRL in 1950 from Sprague Dawley, Inc. Caesarean rederived in 1955 from original Charles River Sprague Dawley. colonies. In 1991, 8 colonies were selected to form the IGS Foundation Colony. Rederived into isolator foundation colony in 1997. IGS refers to animals bred using the CRL International Genetic Standard system.
Coat Color: Albino
Last Known Status: Unknown





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Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
heart rate
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
blood urea nitrogen level
serum creatinine level
plasma anion gap
heart wet weight
heart weight to body weight ratio
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
minute ventilation
liver wet weight
arterial blood flow rate
tidal volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
mammary tumor number
post-insult time to mammary tumor formation
serum total cholesterol level
total white blood cell count
serum total bilirubin level
blood pH
partial pressure of blood oxygen
food intake rate
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum estradiol level
serum progesterone level
plasma angiotensin II level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
plasma very low density lipoprotein cholesterol level
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
urine creatinine excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
plasma lactate level
food intake weight to body weight ratio
serum globulin level
plasma pyruvate level
urine creatine excretion rate
urine taurine excretion rate
plasma acetaminophen level
plasma acetaminophen level area under curve
plasma glutamate dehydrogenase activity level
liver oxidized glutathione level to liver weight ratio
liver reduced glutathione level to liver weight ratio
urine protein level to urine creatinine level ratio
plasma AMG-8718 level area under curve (AUC)
plasma AMG-8718 maximum concentration
full retina thickness
retinal outer layer thickness
retinal inner layer thickness
retinal outer nuclear layer photoreceptor nucleus count
retinal outer nuclear layer thickness

References

References - curated
# Reference Title Reference Citation
1. Oral exposure to bisphenol a increases dimethylbenzanthracene-induced mammary cancer in rats. Jenkins S, etal., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7.
2. Role of genetic modifiers in an orthologous rat model of ARPKD. O'Meara CC, etal., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5.
3. The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass. Paglialunga S, etal., Appl Physiol Nutr Metab. 2017 Jun;42(6):647-655. doi: 10.1139/apnm-2016-0585. Epub 2017 Jan 31.
4. Strains registered by Charles River Laboratories International, Inc. Personal communication with Charles River Laboratories
5. PhysGen Strains PhysGen strains
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease The blood pressure of females is 110 mmHg and of males is 120 mmHg. 629526
strain_other The average weight of females is 231g and of males 388g. 629526

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-01-22 Crl:CD(SD)    Crl:CD(SD)    Name updated 68913 APPROVED
2015-01-22 Crl:CD(SD)    Crl:CD(SD)    Name updated 68913 APPROVED