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Strain Registration

Strain: SS.LEW-(D3Rat52-D3Rat130)/Ayd

Symbol: SS.LEW-(D3Rat52-D3Rat130)/Ayd
Strain: SS.LEW-(D3Rat52-D3Rat130)
Substrain: Ayd
RGD ID: 731192
Citation ID: RRID:RGD_731192
Ontology ID: RS:0000882
Previously known as: SS.LEW-(D3Rat52-D3Rat130)/Ayd; S.L.3; S.L3; SS.LEW-(D3Rat2-D3Chm79)/Ayd; SS.LEW-(D3Rat2-D3Chm79)/Ayd; C3S.L3
Type: congenic
Source: Research Centre-CHUM, Montreal, Quebec, Canada
Origin: A sub congenic strain derived from the progenitor strain SS.LEW-(D3Rat52-D3Rat17)/Ayd
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2318,311,454 - 47,233,430RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0314,090,411 - 48,562,146RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0319,410,399 - 55,227,748RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4314,051,872 - 44,551,542RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Modularization and epistatic hierarchy determine homeostatic actions of multiple blood pressure quantitative trait loci. Chauvet C, etal., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28.
2. Distinct genomic replacements from Lewis correct diastolic dysfunction, attenuate hypertension, and reduce left ventricular hypertrophy in Dahl salt-sensitive rats. Deng AY, etal., J Hypertens. 2008 Oct;26(10):1935-1943.
3. Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats. Duong C, etal., Mamm Genome. 2006 Dec;17(12):1147-61. Epub 2006 Dec 1.
4. Quantitative trait loci with opposing blood pressure effects demonstrating epistasis on Dahl rat chromosome 3. Palijan A, etal., Physiol Genomics 2003 Sep 29;15(1):1-8.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D3Rat52)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2318,311,454 - 18,311,610 (+)MAPPER
Rnor_6.0314,090,411 - 14,090,566NCBI
Rnor_5.0319,410,399 - 19,410,554UniSTS
RGSC_v3.4314,051,872 - 14,052,028RGD
RGSC_v3.4314,051,873 - 14,052,028UniSTS
RGSC_v3.1313,948,245 - 13,948,400RGD
Celera313,028,531 - 13,028,700UniSTS
RH 3.4 Map3157.8RGD
RH 3.4 Map3157.8UniSTS
RH 2.0 Map347.5RGD
SHRSP x BN Map34.6298RGD
Cytogenetic Map3p11UniSTS

Flank 2 / 1 (D3Rat130)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2347,233,211 - 47,233,430 (+)MAPPER
Rnor_6.0348,561,928 - 48,562,146NCBI
Rnor_5.0355,227,530 - 55,227,748UniSTS
RGSC_v3.4344,551,324 - 44,551,542UniSTS
RGSC_v3.4344,551,252 - 44,551,542RGD
RGSC_v3.1344,447,696 - 44,447,914RGD
Celera346,874,375 - 46,874,593UniSTS
RH 3.4 Map3601.73RGD
RH 3.4 Map3601.73UniSTS
RH 2.0 Map3376.6RGD
SHRSP x BN Map332.8199RGD
FHH x ACI Map332.74RGD
Cytogenetic Map3q21UniSTS
Strain QTL Data
Symbol Name Trait
Am5 Aortic mass QTL 5 aorta mass   (VT:0002845)    
Bp151 Blood pressure QTL 151 arterial blood pressure trait   (VT:2000000)    
Bw180 Body weight QTL 180 body mass   (VT:0001259)    
Cm91 Cardiac mass QTL 91 heart mass   (VT:0007028)    
Cm92 Cardiac mass QTL 92 heart left ventricle mass   (VT:0007031)    
Cm93 Cardiac mass QTL 93 heart right ventricle mass   (VT:0007033)    
Kidm63 Kidney mass QTL 63 kidney mass   (VT:0002707)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Mean arterial, diastolic and systolic pressures of this strain are much lower than the SS strain. 724791