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Strain: Iusm:HAD2

Symbol: Iusm:HAD2
Strain: HAD2
Substrain: Iusm
Full Name: high-alcohol-drinking
RGD ID: 731187
Citation ID: RRID:RGD_731187
Ontology ID: RS:0000390
Previously known as: HAD2
Type: outbred
Source: Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana
Origin: These were developed by selective breeding for alcohol preference and consumption from the heterogeneous N/N strain. 8 inbred rat strains were intercrossed. Within-family selection and a rotational breeding design were employed to reduce inbreeding and to allow maintenance of non-inbred replicate lines. Replicate lines were independently selected for high alcohol drinking (HAD1 and HAD2).
Last Known Status: Unknown

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. Bone mass and strength: phenotypic and genetic relationship to alcohol preference in P/NP and HAD/LAD rats. Alam I, etal., Alcohol Clin Exp Res. 2005 Oct;29(10):1769-76. doi: 10.1097/01.alc.0000183005.28502.4f.
2. Analyses of quantitative trait loci contributing to alcohol preference in HAD1/LAD1 and HAD2/LAD2 rats. Carr LG, etal., Alcohol Clin Exp Res 2003 Nov;27(11):1710-7.
3. Identification of quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinking rat lines. Foroud T, etal., Behav Genet 2000 Mar;30(2):131-40.
4. Confirmation of alcohol preference quantitative trait loci in the replicate high alcohol drinking and low alcohol drinking rat lines. Foroud T, etal., Psychiatr Genet 2003 Sep;13(3):155-61.
5. Alcohol preference and voluntary alcohol intakes of inbred rat strains and the National Institutes of Health heterogeneous stock of rats. Li TK and Lumeng L, Alcohol Clin Exp Res. 1984 Sep-Oct;8(5):485-6. doi: 10.1111/j.1530-0277.1984.tb05708.x.
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Strain QTL Data
Symbol Name Trait
Alc12 Alcohol consumption QTL 12 consumption behavior trait   (VT:0002069)    
Alc13 Alcohol consumption QTL 13 consumption behavior trait   (VT:0002069)    

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-03-08 Iusm:HAD2  high-alcohol-drinking  HAD2  high-alcohol-drinking  Symbol and/or name change 68913 APPROVED