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Strain: SS.LEW-(D10Rat24-Igfbp4)/Ayd

Symbol: SS.LEW-(D10Rat24-Igfbp4)/Ayd
Strain: SS.LEW-(D10Rat24-Igfbp4)
Substrain: Ayd
RGD ID: 728384
Citation ID: RRID:RGD_728384
Ontology ID: RS:0000852
Previously known as: S.LEW-D10Rat24/Igfbp4; S.L12; C10S.L12; SS.LEW-(D10Rat24-Igfbp4)/Ayd
Type: congenic
Source: Centre Hospitalier de Universiti de Montrial, Quebec, Canada
Origin: A segment of chromosome 10 was transferred from LEW into the SS background. Two congenic strains, designated S.L4 and S.L5, that were previously shown to have trapped 2 BP QTLs, were used to derive congenic substrains. The F2 rats were genotyped for markers that resided in a region of interest. Each rat was then backcrossed to an SS rat to duplicate the fragment.
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21075,631,887 - 84,007,272RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01078,343,027 - 86,962,563RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01078,194,957 - 86,759,484RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41079,229,067 - 87,834,315RGD_MAPPER_PIPELINERGSC3.4

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. Epistasis, not numbers, regulates functions of clustered Dahl rat quantitative trait loci applicable to human hypertension. Charron S, etal., Hypertension. 2005 Dec;46(6):1300-8. Epub 2005 Nov 14.
2. Modularization and epistatic hierarchy determine homeostatic actions of multiple blood pressure quantitative trait loci. Chauvet C, etal., Hum Mol Genet. 2013 Nov 15;22(22):4451-9. doi: 10.1093/hmg/ddt294. Epub 2013 Jun 28.
3. Submegabase resolution of epistatically interacting quantitative trait loci for blood pressure applicable for essential hypertension. Chauvet C, etal., J Hypertens. 2008 May;26(5):893-901.
4. Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats. Duong C, etal., Mamm Genome. 2006 Dec;17(12):1147-61. Epub 2006 Dec 1.
5. Comprehensive Congenic Coverage Revealing Multiple Blood Pressure Quantitative Trait Loci on Dahl Rat Chromosome 10. Palijan A, etal., Hypertension 2003 Oct;42(4):515-22. Epub 2003 Aug 25
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Position Markers

Flank 1 / 1 (D10Rat24)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21075,631,887 - 75,632,053 (+)MAPPER
Rnor_6.01078,343,027 - 78,343,192NCBI
Rnor_5.01078,194,957 - 78,195,122UniSTS
RGSC_v3.41079,229,067 - 79,229,233RGD
RGSC_v3.41079,229,068 - 79,229,233UniSTS
RGSC_v3.11079,243,438 - 79,243,603RGD
Celera1074,527,028 - 74,527,193UniSTS
RH 3.4 Map10684.69RGD
RH 3.4 Map10684.69UniSTS
RH 2.0 Map10804.1RGD
SHRSP x BN Map1052.2699RGD
Cytogenetic Map10q26UniSTS

Flank 2 / 1 (Igfbp4)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21083,995,253 - 84,007,272 (+)NCBI
mRatBN7.2 Ensembl1083,989,591 - 84,007,225 (+)Ensembl
UTH_Rnor_SHR_Utx1088,939,170 - 88,951,179 (+)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.01088,437,283 - 88,449,292 (+)NCBI
UTH_Rnor_WKY_Bbb_1.01083,829,446 - 83,841,461 (+)NCBI
Rnor_6.01086,950,555 - 86,962,563 (+)NCBI
Rnor_6.0 Ensembl1086,950,557 - 86,962,578 (+)Ensembl
Rnor_5.01086,747,476 - 86,759,484 (+)NCBI
RGSC_v3.41087,822,429 - 87,834,315 (+)NCBI
RGSC_v3.11087,836,798 - 87,848,684 (+)NCBI
Celera1082,736,335 - 82,748,330 (+)NCBI
RH 3.4 Map10860.1RGD
Cytogenetic Map10q31NCBI
Strain QTL Data
Symbol Name Trait
Am11 Aortic mass QTL 11 aorta mass   (VT:0002845)    
Bp281 Blood pressure QTL 281 arterial blood pressure trait   (VT:2000000)    
Kidm38 Kidney mass QTL 38 kidney mass   (VT:0002707)    

Additional Information