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Strain Registration

Strain: SHR/N-cp

Symbol: SHR/N-cp
Strain: SHR-cp
Substrain: N
RGD ID: 728195
Citation ID: RRID:RRRC_00231
Ontology ID: RS:0000750
Previously known as: SHR/N-cp
Type: congenic
Source: Rat Resource and Research Center
Origin: The spontaneously hypertensive corpulent (SHR/N-cp) rat developed at the National Institutes of Health (NIH) is a congenic strain in which obese homozygotes {cp/cp) are characterized by genetic obesity, mild hypertension, hyper-insulinemia, and glucose intolerance. This rat strain was initially derived by mating a male Koletsky rat that was heterozygous for the corpulent gene (cp/ +) to a female SHR ratof the Okamoto strain. A minimum of 12 backcrosses were carried out to eliminate the non-cp genes of the Ko-letsky strain. The obese (cp/cp) littermates develop glucosuria, proteinuria, and renal structural lesions resemblingdiabetic glomerulosclerosis.
Genetic Markers: cp (autosomal recessive)
Genetic Status: Homozygous
Inbred Generations: F8
Last Known Status: Cryopreserved Embryo (as of 2021-01-20)





References

References - curated
# Reference Title Reference Citation
1. NIH Rat Strain Data NIH Rat Strain Data
2. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Effect of carbohydrate intake on kidney function and structure in SHR/N-cp rats. A new model of NIDDM. Velasquez MT, etal., Diabetes. 1989 Jun;38(6):679-85. doi: 10.2337/diab.38.6.679.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
null KOLETSKY rats were derived from breeding of a hypertensive female SHR(Okamoto and Aoki 1963) with a normotensive male of Sprague-Dawley. After several generations of selective inbreeding of hypertensive offspring from this cross, an abnormal phenotype by marked obesity and genetic mutation was noted smong some of the litters  

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-04-18 SHR/N-cp    SHR/N-cp    Name updated 68913 APPROVED
2011-12-02 SHR/N-cp    SHR/N-cp    Name updated 68913 APPROVED
2011-12-02 SHR/N-cp    SHR/N-cp    Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00231 RGD