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Strain: SHRSP/A3N

Symbol: SHRSP/A3N
Strain: SHRSP
Substrain: A3N
RGD ID: 728184
Citation ID: RRID:RGD_728184
Ontology ID: RS:0000775
Type: inbred
Available Source: Not Available
Origination: NIH Autoimmune Rat Model Repository and Development Center
Description: To NIH in 1975 from Yamori at F36. SHR was isolated from Wistar Kyoto rats by Okamoto and Aoki in 1963. SHR was later separated into several sublines; the A3 subline was found to have a high incidence of cerebrovascular lesions. (517)
Genetic Markers: c Albino
Inbred Generations: F47
Last Known Status: Extinct (as of 2020-04-21)

Disease Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. The angiotensin type 1 receptor antagonist, eprosartan, attenuates the progression of renal disease in spontaneously hypertensive stroke-prone rats with accelerated hypertension. Abrahamsen CT, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):21-8. doi: 10.1124/jpet.301.1.21.
2. Carvedilol prevents and reverses hypertrophy-induced cardiac dysfunction. Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4.
3. Genetic relationship between a lymphocyte membrane abnormality and blood pressure in spontaneously hypertensive stroke prone and Wistar-Kyoto rats. Furspan PB, etal., J Hypertens. 1987 Jun;5(3):293-7. doi: 10.1097/00004872-198706000-00005.
4. NIH Rat Strain Data NIH Rat Strain Data
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Enrasentan improves survival, limits left ventricular remodeling, and preserves myocardial performance in hypertensive cardiac hypertrophy and dysfunction. Willette RN, etal., J Cardiovasc Pharmacol. 2001 Oct;38(4):606-17. doi: 10.1097/00005344-200110000-00013.
7. Renoprotective effects of carvedilol in hypertensive-stroke prone rats may involve inhibition of TGF beta expression. Wong VY, etal., Br J Pharmacol. 2001 Nov;134(5):977-84. doi: 10.1038/sj.bjp.0704329.


Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-07 SHRSP/A3N    SHRSP/A3N    Name updated 68913 APPROVED
2015-04-07 SHRSP/A3N    SHRSP/A3N    Name updated 68913 APPROVED
2013-04-15 SHRSP/A3N    SHRSP/A3N    Name updated 68913 APPROVED
2013-04-15 SHRSP/A3N    SHRSP/A3N    Name updated 68913 APPROVED