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Strain Registration

Strain: BBDR.BBDP-(D4Mit6-D4Mit7)/1Rhw

Symbol: BBDR.BBDP-(D4Mit6-D4Mit7)/1Rhw
Strain: BBDR.BBDP-(D4Mit6-D4Mit7)
Substrain: 1Rhw
RGD ID: 728155
Citation ID: RRID:RGD_728155
Ontology ID: RS:0000074
Previously known as: BB/DR.BB/DP-(D4Mit6-D4Mit7)/Rhw; BBDR.BBDP-(D4Mit6-D4Mit7)/Rhw; DR.Gimap5; DR.Gimap5; MDC-03-08; DR.Gimap5; BBDR.BBDP-(D4Mit6-D4Mit7)/1Rhw
Type: congenic
Source: Department of Medicine, University of Washington, Seattle, Washington
Origin: This congenic strain was developed by cyclic cross-intercross breeding using diabetic prone and diabetic resistant BB rats. (DP x DR)F1 x DR cross intercross breeding was used to generate F2 lymphopenic rats. These were then genotyped for both the flanking markers of the Gimap5 gene.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2476,647,384 - 78,886,189RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0477,307,388 - 79,562,753RGD_MAPPER_PIPELINERnor6.0
Rnor_5.04141,978,848 - 141,979,031RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4475,732,943 - 75,733,127RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Increased Lipid Oxidation Heralds Diabetes Onset in DR.lyp/lyp Rats. Akesson L, etal., Exp Clin Endocrinol Diabetes. 2008 May 9;.
2. The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats. Bieg S, etal., Diabetologia 1997 Jul;40(7):786-92.
3. Introgression of F344 Rat Genomic DNA on BB Rat Chromosome 4 Generates Diabetes-Resistant Lymphopenic BB Rats. Fuller JM, etal., Diabetes. 2006 Dec;55(12):3351-7.
4. Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats. Moralejo DH, etal., Physiol Genomics. 2010 Mar 3;41(1):9-20. Epub 2009 Dec 8.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D4Mit6)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2476,647,384 - 76,647,568 (+)MAPPER
Rnor_6.0477,307,388 - 77,307,571NCBI
Rnor_5.04141,978,848 - 141,979,031UniSTS
RGSC_v3.4475,732,943 - 75,733,127RGD
RGSC_v3.4475,732,944 - 75,733,127UniSTS
Celera471,452,122 - 71,452,305UniSTS
Cytogenetic Map4q24UniSTS

Flank 2 / 1 (D4Mit7)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2478,885,890 - 78,886,189 (+)MAPPER
Rnor_6.0479,562,451 - 79,562,753RGD

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other These contain a mutation in the Gimap5 gene which results in the truncation of Gimap5 protein 2293508
strain_phys_biochem Increase in lipid oxidation was observed prior to diabetes onset 2293508