Strain Report - Rat Genome Database

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Strain: WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/Bbb

Symbol: WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/Bbb
Strain: WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)
Substrain: Bbb
RGD ID: 728139
Citation ID: RRID:RGD_728139
Ontology ID: RS:0001045
Also Known As: W.S.1/10; WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/Bbb
Type: congenic
Available Source: Not Available
Origination: Max-Delbruck-Center for Molecular Medicine, Berlin, Germany
Description: This double congenic strain was constructed by using the SHRSP strain as a donor strain to transfer the chromosome 1 Bp QTL to the chromosome 10 congenic strain in a cross between SHRSP and WKY.SHRSP-(Shbg-Atp1b2) to construct an F1 that was then backcrossed to the congenic WKY.SHRSP-(Shbg-Atp1b2) for more than 10 generations to construct the double congenic strain now homozygous for the SS Bp QTL alleles at both the chromosome 10 and chromosome 1 Bp QTLs
Inbred Generations: F10
Last Known Status: Unknown

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References - curated
# Reference Title Reference Citation
1. Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10. Monti J, etal., Hum Mol Genet 2003 Feb 15;12(4):435-9.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Strain QTL Data
Symbol Name Trait
Bp106 Blood pressure QTL 106 arterial blood pressure trait   (VT:2000000)    
Bp107 Blood pressure QTL 107 arterial blood pressure trait   (VT:2000000)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This double congenic strain carries SHRSP blood pressure QTLs Bp106 and Bp107 on a WKY background 629620