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Strain: SHR/NHsd

Symbol: SHR/NHsd
Strain: SHR
Substrain: NHsd
RGD ID: 724574
Citation ID: RRID:RGD_724574
Ontology ID: RS:0000754
Previously known as: MDC-03-82
Type: inbred
Source: Envigo
Origin: SHR strain obtained from Harlan Sprague-Dawley (Indianapolis, IN)
Last Known Status: Unknown


References - curated
# Reference Title Reference Citation
1. Contribution of autosomal loci and the Y chromosome to the stress response in rats. Dumas P, etal., Hypertension 2000 Feb;35(2):568-73
2. Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet. Garrett MR, etal., J Am Soc Nephrol 2003 May;14(5):1175-87.
3. Blood pressure QTL that differentiate dahl salt-sensitive and spontaneously hypertensive rats Garrett MR, etal., Physiol Genomics 2000 Jun 29;3(1):33-8.
4. Genetic linkage of urinary albumin excretion in Dahl salt-sensitive rats: influence of dietary salt and confirmation using congenic strains. Garrett MR, etal., Physiol Genomics. 2006 Mar 13;25(1):39-49.
5. Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment. Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.
6. Linkage Analysis of Neointimal Hyperplasia and Vascular Wall Transformation Following Balloon Angioplasty. Nestor AL, etal., Physiol Genomics. 2006 Jan 24;.
7. Neointimal hyperplasia and vasoreactivity are controlled by genetic elements on rat chromosome 3. Nestor Kalinoski AL, etal., Hypertension. 2010 Feb;55(2):555-61. Epub 2009 Dec 21.
8. Strains registered by Harlan Laboratories, Inc. Personal communication with Harlan Laboratories
9. RGD Strain RSO annotation pipeline RGD Automated Pipelines
10. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.


Strain QTL Data
Symbol Name Trait
Bp62 Blood pressure QTL 62 arterial blood pressure trait   (VT:2000000)    
Bp92 Blood pressure QTL 92 arterial blood pressure trait   (VT:2000000)    
Bw108 Body weight QTL 108 body mass   (VT:0001259)    
Bw109 Body weight QTL 109 body mass   (VT:0001259)    
Bw110 Body weight QTL 110 body mass   (VT:0001259)    
Bw111 Body weight QTL 111 body mass   (VT:0001259)    
Cm16 Cardiac mass QTL 16 heart mass   (VT:0007028)    
Cm17 Cardiac mass QTL 17 heart mass   (VT:0007028)    
Cm18 Cardiac mass QTL 18 heart mass   (VT:0007028)    
Cm19 Cardiac mass QTL 19 heart mass   (VT:0007028)    
Cm20 Cardiac mass QTL 20 heart mass   (VT:0007028)    
Cm21 Cardiac mass QTL 21 heart mass   (VT:0007028)    
Cm28 Cardiac mass QTL 28 heart mass   (VT:0007028)    
Cm52 Cardiac mass QTL 52 heart mass   (VT:0007028)    
Cm53 Cardiac mass QTL 53 heart mass   (VT:0007028)    
Kidm1 Kidney mass QTL 1 kidney mass   (VT:0002707)    
Kidm2 Kidney mass QTL 2 kidney mass   (VT:0002707)    
Kidm29 Kidney mass QTL 29 kidney mass   (VT:0002707)    
Kidm3 Kidney mass QTL 3 kidney mass   (VT:0002707)    
Klgr1 Kidney lesion grade QTL 1 kidney morphology trait   (VT:0002135)    
Pur2 Proteinuria QTL 2 urine protein amount   (VT:0005160)    
Pur4 Proteinuria QTL 4 urine total protein amount   (VT:0000032)    
Pur5 Proteinuria QTL 5 urine total protein amount   (VT:0000032)    
Pur6 Proteinuria QTL 6 urine total protein amount   (VT:0000032)    
Uae10 Urinary albumin excretion QTL 10 urine albumin amount   (VT:0002871)    
Uae11 Urinary albumin excretion QTL 11 urine albumin amount   (VT:0002871)    
Uae12 Urinary albumin excretion QTL 12 urine albumin amount   (VT:0002871)    
Uae30 Urinary albumin excretion QTL 30 urine albumin amount   (VT:0002871)    
Uae31 Urinary albumin excretion QTL 31 urine albumin amount   (VT:0002871)    
Uae39 Urinary albumin excretion QTL 39 urine albumin amount   (VT:0002871)    
Uae5 Urinary albumin excretion QTL 5 urine albumin amount   (VT:0002871)    
Uae6 Urinary albumin excretion QTL 6 urine albumin amount   (VT:0002871)    
Uae7 Urinary albumin excretion QTL 7 urine albumin amount   (VT:0002871)    
Uae8 Urinary albumin excretion QTL 8 urine albumin amount   (VT:0002871)    
Uae9 Urinary albumin excretion QTL 9 urine albumin amount   (VT:0002871)    
Vnigr1 Vascular neointimal growth QTL 1 artery morphology trait   (VT:0002191)    
Vnigr2 Vascular neointimal growth QTL 2 artery morphology trait   (VT:0002191)    
Vnigr3 Vascular neointimal growth QTL 3 artery morphology trait   (VT:0002191)    
Damaging Variants
Number of Damaging Variants
SHR/NHsd (ICL) 709
SHR/NHsd (KNAW) 837
SHR/NHsd (RGD) 1173

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Selectively bred for displaying high blood pressure that is independent of diet 61516
strain_other These have shorter survival time after controlled hemorrhage than BN/HsdMcwiCrl but longer than DA/OlaHsd. 2302114

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-09-24 SHR/NHsd    SHR/NHsd    Name updated 68913 APPROVED
2014-09-24 SHR/NHsd    SHR/NHsd    Name updated 68913 APPROVED