Strain Report - Rat Genome Database

Name: SS/JrTol
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SS/JrTol
Symbol:	SS/JrTol
Strain:	SS
Substrain:	JrTol
Full Name:	Dahl salt-sensitive (SS/Jr) rats
RGD ID:	724573
Citation ID:	RRID:RGD_724573
Ontology ID:	RS:0000924
Previously known as:	SS/JrMco
Type:	inbred
Source:	Housed at the University of Toledo College of Medicine and Life Sciences.
Origin:	In the 1960s, Dahl selectively bred rats for sensitivity (SS rats) to the hypertensive effect of high-salt diet.
Last Known Status:	Live Animals (as of 2021-06-08)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Albuminuria (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

increased blood urea nitrogen level (IAGP)

increased circulating bicarbonate level (IAGP)

increased circulating cholesterol level (IAGP)

increased circulating potassium level (IAGP)

increased circulating sodium level (IAGP)

increased circulating triglyceride level (IAGP)

increased kidney weight (IAGP)

renal glomerulus fibrosis (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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References

References - curated

#	Reference Title	Reference Citation
1.	Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet.	Garrett MR, etal., J Am Soc Nephrol 2003 May;14(5):1175-87.
2.	Dissection of a Genetic Locus Influencing Renal Function in the Rat and its Concordance with Kidney Disease Loci on Human Chromosome 1q21.	Garrett MR, etal., Physiol Genomics. 2007 May 15;.
3.	Will the real Dahl S rat please stand up?	Rapp JP and Garrett MR, Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1231-F1240. doi: 10.1152/ajprenal.00359.2019. Epub 2019 Sep 23.
4.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Strain QTL Data

Symbol	Name	Trait
Cm16	Cardiac mass QTL 16	heart mass (VT:0007028)
Cm17	Cardiac mass QTL 17	heart mass (VT:0007028)
Cm18	Cardiac mass QTL 18	heart mass (VT:0007028)
Cm19	Cardiac mass QTL 19	heart mass (VT:0007028)
Cm20	Cardiac mass QTL 20	heart mass (VT:0007028)
Cm21	Cardiac mass QTL 21	heart mass (VT:0007028)
Kidm1	Kidney mass QTL 1	kidney mass (VT:0002707)
Kidm2	Kidney mass QTL 2	kidney mass (VT:0002707)
Kidm3	Kidney mass QTL 3	kidney mass (VT:0002707)
Pur2	Proteinuria QTL 2	urine protein amount (VT:0005160)
Uae10	Urinary albumin excretion QTL 10	urine albumin amount (VT:0002871)
Uae11	Urinary albumin excretion QTL 11	urine albumin amount (VT:0002871)
Uae12	Urinary albumin excretion QTL 12	urine albumin amount (VT:0002871)
Uae5	Urinary albumin excretion QTL 5	urine albumin amount (VT:0002871)
Uae6	Urinary albumin excretion QTL 6	urine albumin amount (VT:0002871)
Uae7	Urinary albumin excretion QTL 7	urine albumin amount (VT:0002871)
Uae8	Urinary albumin excretion QTL 8	urine albumin amount (VT:0002871)
Uae9	Urinary albumin excretion QTL 9	urine albumin amount (VT:0002871)

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_life_disease	Besides fulminant hypertension, these rats on high-salt diet develop progressive proteinuria and severe renal vascular and glomerular lesions and associated renal tubular lesions.	634617

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-06-08	SS/JrTol	Dahl salt-sensitive (SS/Jr) rats	SS/JrMco	Dahl salt-sensitive (SS/Jr) rats	Symbol and/or name change	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SS/JrTol

Mammalian Phenotype

Related Phenotype Data for Term "SS/JrTol" (RS:0000924)