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Strain: SS/JrTol

Symbol: SS/JrTol
Strain: SS
Substrain: JrTol
Full Name: Dahl salt-sensitive (SS/Jr) rats
RGD ID: 724573
Citation ID: RRID:RGD_724573
Ontology ID: RS:0000924
Also Known As: SS/JrMco
Type: inbred
Available Source: Not Available
Origination: Housed at the University of Toledo College of Medicine and Life Sciences.
Description: In the 1960s, Dahl selectively bred rats for sensitivity (SS rats) to the hypertensive effect of high-salt diet.
Last Known Status: Live Animals (as of 2021-06-08)


References - curated
# Reference Title Reference Citation
1. Time-course genetic analysis of albuminuria in Dahl salt-sensitive rats on low-salt diet. Garrett MR, etal., J Am Soc Nephrol 2003 May;14(5):1175-87.
2. Dissection of a Genetic Locus Influencing Renal Function in the Rat and its Concordance with Kidney Disease Loci on Human Chromosome 1q21. Garrett MR, etal., Physiol Genomics. 2007 May 15;.
3. Will the real Dahl S rat please stand up? Rapp JP and Garrett MR, Am J Physiol Renal Physiol. 2019 Nov 1;317(5):F1231-F1240. doi: 10.1152/ajprenal.00359.2019. Epub 2019 Sep 23.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Strain QTL Data
Symbol Name Trait
Cm16 Cardiac mass QTL 16 heart mass   (VT:0007028)    
Cm17 Cardiac mass QTL 17 heart mass   (VT:0007028)    
Cm18 Cardiac mass QTL 18 heart mass   (VT:0007028)    
Cm19 Cardiac mass QTL 19 heart mass   (VT:0007028)    
Cm20 Cardiac mass QTL 20 heart mass   (VT:0007028)    
Cm21 Cardiac mass QTL 21 heart mass   (VT:0007028)    
Kidm1 Kidney mass QTL 1 kidney mass   (VT:0002707)    
Kidm2 Kidney mass QTL 2 kidney mass   (VT:0002707)    
Kidm3 Kidney mass QTL 3 kidney mass   (VT:0002707)    
Pur2 Proteinuria QTL 2 urine protein amount   (VT:0005160)    
Uae10 Urinary albumin excretion QTL 10 urine albumin amount   (VT:0002871)    
Uae11 Urinary albumin excretion QTL 11 urine albumin amount   (VT:0002871)    
Uae12 Urinary albumin excretion QTL 12 urine albumin amount   (VT:0002871)    
Uae5 Urinary albumin excretion QTL 5 urine albumin amount   (VT:0002871)    
Uae6 Urinary albumin excretion QTL 6 urine albumin amount   (VT:0002871)    
Uae7 Urinary albumin excretion QTL 7 urine albumin amount   (VT:0002871)    
Uae8 Urinary albumin excretion QTL 8 urine albumin amount   (VT:0002871)    
Uae9 Urinary albumin excretion QTL 9 urine albumin amount   (VT:0002871)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Besides fulminant hypertension, these rats on high-salt diet develop progressive proteinuria and severe renal vascular and glomerular lesions and associated renal tubular lesions. 634617

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-06-08 SS/JrTol  Dahl salt-sensitive (SS/Jr) rats  SS/JrMco  Dahl salt-sensitive (SS/Jr) rats  Symbol and/or name change 68913 APPROVED