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Strain: LE-Lrrk2em1Sage-/-

Symbol: LE-Lrrk2em1Sage-/-
Strain: LE-Lrrk2em1-/-
Substrain: Sage
RGD ID: 7241056
Citation ID: RRID:RGD_7241056
Ontology ID: RS:0003393
Alleles: Lrrk2em1Sage
Also Known As: LE-Lrrk2em1Sage-/-; LE-Lrrk2em1Sage-/Lrrk2em1Sage-; TGRL4620 ; LE-Lrrk2^[em1Sage-/-]
Type: mutant
Available Source: Sigma Advanced Genetic Engineering Labs
Origination: Sigma Advanced Genetic Engineering Labs
Description: ZFN mutant founders were backcrossed with Crl:LE to get heterozygous offspring which were intercrossed and offsprings maintained as homozygous
Genetic Status: Homozygous
Last Known Status: Live Animals (as of 2018-08-24)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27122,826,696 - 122,987,711RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.07132,857,311 - 133,018,549RGD_MAPPER_PIPELINERnor6.0
Rnor_5.07132,531,591 - 132,694,226RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.47130,105,902 - 130,267,747RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View


Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
body weight
heart weight
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
red blood cell distribution width-coefficient of variation
blood urea nitrogen level
plasma total protein level
plasma albumin level
serum creatinine level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
plasma calcium level
liver weight
lung weight
urine potassium level
urine sodium level
urine albumin level
liver weight as percentage of body weight
adrenal gland weight
spleen weight
testis weight
kidney wet weight
urine specific gravity
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood insulin level
serum total cholesterol level
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
urine chloride level
serum chloride level
serum sodium level
blood testosterone level
blood progesterone level
blood cortisol level
plasma creatinine level
serum phosphate level
plasma triglyceride level
blood adrenocorticotropic hormone level (ACTH)
blood alanine aminotransferase activity level
blood alkaline phosphatase activity level
blood angiotensin I converting enzyme activity level
blood aspartate aminotransferase activity level
plasma total cholesterol level
thymus weight
thymus weight to body weight ratio
single kidney wet weight to body weight ratio
creatinine clearance
blood leptin level
both testes wet weight to body weight ratio
blood insulin-like growth factor 1 level
blood prolactin level
plasma gamma-glutamyltransferase activity level
plasma total bilirubin level
blood segmented neutrophil count
blood segmented neutrophil count to total leukocyte count ratio
lung wet weight to body weight ratio
serum cystatin C level
urine sodium level to urine creatinine level ratio
urine potassium level to urine creatinine level ratio
gastrointestinal tract weight
reticulocyte count to total red blood cell count ratio
urine chloride level to urine creatinine level ratio
gastrointestinal tract weight to body weight ratio
blood galanin level
blood lutenizing hormone level
urine lipocalin 2 level
urine osteopontin level
urine KIM-1/TIM-1/HAVCR level
serum beta-2 microglobulin
serum calbindin level
serum clusterin level
serum glutathione S-transferase-alpha level
serum glutathione S-transferase-u level
serum tissue inhibitor of metalloproteinase 1 level
serum vascular endothelial growth factor A level
serum lipocalin 2 level
serum osteopontin level
serum KIM-1/TIM-1/HAVCR1
serum sorbital dehydrogenase activity
plasma plasminogen activator inhibitor 1 level
plasma Complement C3a des Arg level

References

References - curated
# Reference Title Reference Citation
1. Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs. Baptista MA, etal., PLoS One. 2013 Nov 14;8(11):e80705. doi: 10.1371/journal.pone.0080705. eCollection 2013.
2. Abrogation of a-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats. Daher JP, etal., Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9289-94. doi: 10.1073/pnas.1403215111. Epub 2014 Jun 9.
3. Surfactant secretion in LRRK2 knock-out rats: changes in lamellar body morphology and rate of exocytosis. Miklavc P, etal., PLoS One. 2014 Jan 21;9(1):e84926. doi: 10.1371/journal.pone.0084926. eCollection 2014.
4. Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury and perturbations in metabolic and immunological homeostasis. Ness D, etal., PLoS One. 2013 Jun 14;8(6):e66164. doi: 10.1371/journal.pone.0066164. Print 2013.
5. Data registered by Sigma Advanced Genetic Engineering Labs Personal communication with SAGE Labs and RGD curators
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-27 LE-Lrrk2em1Sage-/-    LE-Lrrk2em1Sage-/-    Name updated 68913 APPROVED
2016-04-27 LE-Lrrk2em1Sage-/-    LE-Lrrk2em1Sage-/-    Name updated 68913 APPROVED
2014-04-03 LE-Lrrk2em1Sage-/-    LE-Lrrk2em1Sage-/-    Name updated 68913 APPROVED
2014-04-03 LE-Lrrk2em1Sage-/-    LE-Lrrk2em1Sage-/-    Name updated 68913 APPROVED
2014-04-03 LE-Lrrk2em1Sage-/-    LE-Lrrk2em1Sage-/-    Symbol updated 68687 APPROVED
2014-04-03 LE-Lrrk2em1Sage-/-    LE-Lrrk2em1Sage-/-    Symbol updated 68687 APPROVED
2013-02-26 LE-Lrrk2em1Sage-/-    LE-Lrrk2em1Sage-/-    Name updated 68913 APPROVED