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Strain Registration

Strain: LE-Park7em1Sage-/-

Symbol: LE-Park7em1Sage-/-
Strain: LE-Park7em1-/-
Substrain: Sage
RGD ID: 7241055
Citation ID: RRID:RGD_7241055
Ontology ID: RS:0003392
Alleles: Park7em1Sage
Also Known As: LE-Park7em1Sage-/-; ;LE-Park7em1Sage-/Park7em1Sage-; TGRL4830; LEH- Park7 tm1sage; Park7 (DJ-1) Knockout Rat; LE-Park7^[em1Sage-/-]
Type: mutant
Available Source: Horizon Discovery
Origination: Horizon Discovery
Description: ZFN mutant founders were backcrossed with Crl:LE to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous. The resulting mutation is a 9-bp deletion with 1-bp insertion in exon 5 (TTGGTGAAGA).
Genetic Status: Homozygous
Last Known Status: Live Animals (as of 2017-05-08)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85166,636,551 - 166,659,825RGD_MAPPER_PIPELINE
mRatBN7.25161,353,718 - 161,376,993RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.05167,982,438 - 168,004,724RGD_MAPPER_PIPELINERnor6.0
Rnor_5.05171,559,202 - 171,582,476RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.45168,050,149 - 168,061,616RGD_MAPPER_PIPELINERGSC3.4





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Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Dave KD, etal., Neurobiol Dis. 2014 Oct;70:190-203. doi: 10.1016/j.nbd.2014.06.009. Epub 2014 Jun 24.
2. Data registered by Sigma Advanced Genetic Engineering Labs Personal communication with SAGE Labs and RGD curators
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats. Sun J, etal., Neurosci Lett. 2013 Dec 17;557 Pt B:123-8. doi: 10.1016/j.neulet.2013.10.034. Epub 2013 Oct 22.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-03 LE-Park7em1Sage-/-    LE-Park7em1Sage-/-    Name updated 68913 APPROVED
2014-04-03 LE-Park7em1Sage-/-    LE-Park7em1Sage-/-    Symbol updated 68687 APPROVED
2014-04-03 LE-Park7em1Sage-/-    LE-Park7em1Sage-/-    Name updated 68913 APPROVED
2014-04-03 LE-Park7em1Sage-/-    LE-Park7em1Sage-/-    Symbol updated 68687 APPROVED
2013-02-26 LE-Park7em1Sage-/-    LE-Park7em1Sage-/-    Name updated 68913 APPROVED