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Strain: LE-Pink1em1Sage-/-

Symbol: LE-Pink1em1Sage-/-
Strain: LE-Pink1em1-/-
Substrain: Sage
RGD ID: 7241049
Citation ID: RRID:RGD_7241049
Ontology ID: RS:0003389
Alleles: Pink1em1Sage
Also Known As: LE-Pink1em1Sage-/-; ;LE-Pink1em1Sage-/Pink1em1Sage-; LEH- Pink1 tm1sage; Pink1 (Park6) Knockout Rat ; TGRL4690 ; LE-Pink1^[em1Sage-/-]
Type: mutant
Available Source: Horizon Discovery
Origination: Horizon Discovery
Description: ZFN mutant founders were backcrossed with Crl:LE to get heterozygous offspring which were intercrossed and offspring maintained as homozygous. This allele was made by ZFN mutagenesis. The resulting mutation is a 26-bp frameshift deletion in exon 4 (ACTACTACCCAGAAGGCCTGGGCCAC).
Genetic Status: Homozygous
Last Known Status: Live Animals (as of 2017-05-08)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25150,530,523 - 150,542,635RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.05156,677,146 - 156,689,258RGD_MAPPER_PIPELINERnor6.0
Rnor_5.05160,425,715 - 160,437,827RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.45157,091,181 - 157,103,293RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease. Dave KD, etal., Neurobiol Dis. 2014 Oct;70:190-203. doi: 10.1016/j.nbd.2014.06.009. Epub 2014 Jun 24.
2. Data registered by Sigma Advanced Genetic Engineering Labs Personal communication with SAGE Labs and RGD curators
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats. Sun J, etal., Neurosci Lett. 2013 Dec 17;557 Pt B:123-8. doi: 10.1016/j.neulet.2013.10.034. Epub 2013 Oct 22.
5. Early Expression of Parkinson's Disease-Related Mitochondrial Abnormalities in PINK1 Knockout Rats. Villeneuve LM, etal., Mol Neurobiol. 2016 Jan;53(1):171-86. doi: 10.1007/s12035-014-8927-y. Epub 2014 Nov 25.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-27 LE-Pink1em1Sage-/-    LE-Pink1em1Sage-/-    Name updated 68913 APPROVED
2016-04-27 LE-Pink1em1Sage-/-    LE-Pink1em1Sage-/-    Name updated 68913 APPROVED
2016-04-27 LE-Pink1em1Sage-/-    LE-Pink1em1Sage-/-    Name updated 68913 APPROVED
2016-04-27 LE-Pink1em1Sage-/-    LE-Pink1em1Sage-/-    Name updated 68913 APPROVED
2014-04-03 LE-Pink1em1Sage-/-    LE-Pink1em1Sage-/-    Name updated 68913 APPROVED
2014-04-03 LE-Pink1em1Sage-/-    LE-Pink1em1Sage-/-    Name updated 68913 APPROVED
2014-04-03 LE-Pink1em1Sage-/-    LE-Pink1em1Sage-/-    Symbol updated 68687 APPROVED
2014-04-03 LE-Pink1em1Sage-/-    LE-Pink1em1Sage-/-    Symbol updated 68687 APPROVED
2013-02-26 LE-Pink1em1Sage-/-    LE-Pink1em1Sage-/-    Name updated 68913 APPROVED
2013-02-26 LE-Pink1em1Sage-/-    LE-Pink1em1Sage-/-    Name updated 68913 APPROVED