Strain Report - Rat Genome Database

Name: LE- Pink1 em1Sage-/-
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: LE-Pink1^em1Sage-/-

Symbol:

LE-Pink1^em1Sage-/-

Strain:

LE-Pink1^em1-/-

Substrain:

Sage

RGD ID:

7241049

Citation ID:

RRID:RGD_7241049

Ontology ID:

RS:0003389

Alleles:

Pink1^em1Sage

Previously known as:

LE-Pink1em1Sage-/-; ;LE-Pink1em1Sage-/Pink1em1Sage-; LEH- Pink1 tm1sage; Pink1 (Park6) Knockout Rat ; TGRL4690

Type:

mutant

Source:

Horizon Discovery

Origin:

ZFN mutant founders were backcrossed with Crl:LE to get heterozygous offspring which were intercrossed and offspring maintained as homozygous. This allele was made by ZFN mutagenesis. The resulting mutation is a 26-bp frameshift deletion in exon 4 (ACTACTACCCAGAAGGCCTGGGCCAC).

Genetic Status:

Homozygous

Last Known Status:

Live Animals (as of 2017-05-08)

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	150,530,523 - 150,542,635	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	5	156,677,146 - 156,689,258	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	5	160,425,715 - 160,437,827	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	5	157,091,181 - 157,103,293	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Parkinson's disease (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal gait (IMP)

abnormal motor coordination/balance (IMP)

abnormal muscle tone (IMP)

decreased brain tyrosine 3-monooxygenase activity (IMP)

decreased grip strength (IMP)

decreased locomotor activity (IMP)

decreased substantia nigra cell number (IMP)

decreased substantia nigra size (IMP)

decreased vertical activity (IMP)

increased body weight (IMP)

increased dopamine level (IMP)

increased oxygen consumption (IMP)

increased serotonin level (IMP)

loss of dopaminergic neurons (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease.	Dave KD, etal., Neurobiol Dis. 2014 Oct;70:190-203. doi: 10.1016/j.nbd.2014.06.009. Epub 2014 Jun 24.
2.	Data registered by Sigma Advanced Genetic Engineering Labs	Personal communication with SAGE Labs and RGD curators
3.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
4.	Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats.	Sun J, etal., Neurosci Lett. 2013 Dec 17;557 Pt B:123-8. doi: 10.1016/j.neulet.2013.10.034. Epub 2013 Oct 22.
5.	Early Expression of Parkinson's Disease-Related Mitochondrial Abnormalities in PINK1 Knockout Rats.	Villeneuve LM, etal., Mol Neurobiol. 2016 Jan;53(1):171-86. doi: 10.1007/s12035-014-8927-y. Epub 2014 Nov 25.

Region

Additional Information

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2016-04-27	LE-Pink1^em1Sage-/-	LE-Pink1^em1Sage-/-	Name updated	68913	APPROVED
2016-04-27	LE-Pink1^em1Sage-/-	LE-Pink1^em1Sage-/-	Name updated	68913	APPROVED
2016-04-27	LE-Pink1^em1Sage-/-	LE-Pink1^em1Sage-/-	Name updated	68913	APPROVED
2016-04-27	LE-Pink1^em1Sage-/-	LE-Pink1^em1Sage-/-	Name updated	68913	APPROVED
2014-04-03	LE-Pink1^em1Sage-/-	LE-Pink1^em1Sage-/-	Name updated	68913	APPROVED
2014-04-03	LE-Pink1^em1Sage-/-	LE-Pink1^em1Sage-/-	Name updated	68913	APPROVED
2014-04-03	LE-Pink1^em1Sage-/-	LE-Pink1^em1Sage-/-	Symbol updated	68687	APPROVED
2014-04-03	LE-Pink1^em1Sage-/-	LE-Pink1^em1Sage-/-	Symbol updated	68687	APPROVED
2013-02-26	LE-Pink1^em1Sage-/-	LE-Pink1^em1Sage-/-	Name updated	68913	APPROVED
2013-02-26	LE-Pink1^em1Sage-/-	LE-Pink1^em1Sage-/-	Name updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: LE-Pink1em1Sage-/-

Mammalian Phenotype

Strain: LE-Pink1^em1Sage-/-