Strain Report - Rat Genome Database

Name: SD- Rag1 em1Ang
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SD-Rag1^em1Ang

Symbol:

SD-Rag1^em1Ang

Strain:

SD-Rag1^em1

Substrain:

Ang

RGD ID:

7204136

Citation ID:

RRID:RGD_7204136

Ontology ID:

RS:0003368

Alleles:

Rag1^em1Ang

Previously known as:

Wild-Rag1em1Ang

Type:

mutant

Source:

Institut National de la Sante et de la Recherche Medicale (INSERM)

Origin:

This strain was produced by injecting ZFNs into Sprague-Dawley rat embryos. The resulting mutation is a 5-bp frameshift deletion in the Rag1 gene that predicts a protein with a normal sequence up to aa 245, followed by 5 aa from the insertions and mutations, followed by a stop codon in position 751.

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	87,917,061 - 87,928,158	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	3	91,206,394 - 91,217,491	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	3	97,866,048 - 97,877,145	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	3	86,780,782 - 86,791,878	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Immune Deficiency Disease (IMP)

severe combined immunodeficiency (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased B cell number (IMP)

decreased bone marrow cell number (IMP)

decreased CD4-positive, alpha-beta T cell number (IMP)

decreased CD8-positive, alpha-beta T cell number (IMP)

decreased mature B cell number (IMP)

decreased NK cell number (IMP)

decreased T cell number (IMP)

decreased thymocyte number (IMP)

lymph node hypoplasia (IMP)

small lymph nodes (IMP)

small spleen (IMP)

small thymus (IMP)

spleen hypoplasia (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases.	Menoret S, etal., FASEB J. 2012 Nov 12.
2.	Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models.	Ménoret S, etal., Transplantation. 2018 Apr 24. doi: 10.1097/TP.0000000000002251.
3.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2018-06-20	SD-Rag1^em1Ang	Wild-Rag1^em1Ang	Symbol updated	68687	APPROVED
2018-06-20	SD-Rag1^em1Ang	Wild-Rag1^em1Ang	Symbol updated	68687	APPROVED
2014-04-03	Wild-Rag1^em1Ang	Wild-Rag1^em1Ang	Name updated	68913	APPROVED
2014-04-03	Wild-Rag1^em1Ang	Wild-Rag1^em1Ang	Name updated	68913	APPROVED
2014-04-03	Wild-Rag1^em1Ang	Wild-Rag1^em1Ang	Symbol updated	68687	APPROVED
2014-04-03	Wild-Rag1^em1Ang	Wild-Rag1^em1Ang	Symbol updated	68687	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SD-Rag1em1Ang

Mammalian Phenotype

Strain: SD-Rag1^em1Ang