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Strain Registration

Strain: F344/DuCrlCrlj

Symbol: F344/DuCrlCrlj
Strain: F344
Substrain: DuCrlCrlj
RGD ID: 69643
Citation ID: RRID:RGD_69643
Ontology ID: RS:0000305
Previously known as: F344/DuCrlCrlj; NBRP Rat No: 0506; F344/DuCrlj
Type: inbred
Source: Charles River Laboratories Japan, National BioResource Project for the Rat in Japan
Origin: This strain originated in 1920 by Curtis then was with Dunning and then with Charles River Japan from 1976.
Inbred Generations: F110
Last Known Status: Live Animals
Research Usage Neurobiology; Cardio Hypertension





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
F344/DuCrlCrlj  IEA 7241799 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
blood glucose amount  EXP 625760; 619670; 69696; 61021 RGD 
body mass  EXP 69691 RGD 
pancreas mass  EXP 69697 RGD 

Phenotype Values via Phenominer Click to see Annotation Detail View

Related Phenotype Data for Term "F344/DuCrlCrlj" (RS:0000305)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
blood glucose level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
abdominal fat pad weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood glucose level area under curve (AUC)
mesenteric fat pad weight
retroperitoneal fat pad weight
epididymal fat pad weight
serum insulin level
serum triglyceride level
serum high density lipoprotein cholesterol level
serum total cholesterol level
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma free fatty acids level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
pancreas wet weight
pancreas weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
serum leptin level
both testes wet weight to body weight ratio
percentage of study population developing leukemia during a period of time
urine sodium excretion rate to body weight ratio
post-insult time to onset of T-cell lymphoma
percentage of study population developing T-cell lymphomas during a period of time
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Kose H, etal., Mamm Genome 2002 Oct;13(10):558-62.
2. Propylnitrosourea-induced T-lymphomas in LEXF RI strains of rats: genetic analysis. Lu LM, etal., Br J Cancer 1999 May;80(5-6):855-61.
3. A major quantitative trait locus co-localizing with cholecystokinin type A receptor gene influences poor pancreatic proliferation in a spontaneously diabetogenic rat. Moralejo DH, etal., Mamm Genome 1998 Oct;9(10):794-8.
4. Identification of quantitative trait loci for non-insulin-dependent diabetes mellitus that interact with body weight in the Otsuka Long-Evans Tokushima Fatty rat. Moralejo DH, etal., Proc Assoc Am Physicians 1998 Nov-Dec;110(6):545-58.
5. Strains registered by Charles River Laboratories International, Inc. Personal communication with Charles River Laboratories
6. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
7. RGD Strain RSO annotation pipeline RGD Automated Pipelines
8. Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima fatty rat by MQM-mapping method. Sugiura K, etal., Mamm Genome 1999 Dec;10(12):1126-31.
9. A disrupted cholecystokinin A receptor gene induces diabetes in obese rats synergistically with ODB1 gene. Takiguchi S, etal., Am J Physiol. 1998 Feb;274(2):E265-70. doi: 10.1152/ajpendo.1998.274.2.E265.
10. Mapping and characterization of quantitative trait loci for non-insulin-dependent diabetes mellitus with an improved genetic map in the Otsuka Long-Evans Tokushima fatty rat. Wei S, etal., Mamm Genome 1999 Mar;10(3):249-58
11. Identification of epistatic interactions involved in non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat. Yamada T, etal., Exp Anim 2001 Apr;50(2):115-23.

Region

Strain QTL Data
Symbol Name Trait
Bw21 Body weight QTL 21 body mass   (VT:0001259)    
Niddm20 Non-insulin dependent diabetes mellitus QTL 20 blood glucose amount   (VT:0000188)    
Niddm21 Non-insulin dependent diabetes mellitus QTL 21 blood glucose amount   (VT:0000188)    
Niddm22 Non-insulin dependent diabetes mellitus QTL 22 blood glucose amount   (VT:0000188)    
Niddm23 Non-insulin dependent diabetes mellitus QTL 23 blood glucose amount   (VT:0000188)    
Niddm24 Non-insulin dependent diabetes mellitus QTL 24 blood glucose amount   (VT:0000188)    
Niddm25 Non-insulin dependent diabetes mellitus QTL 25 blood glucose amount   (VT:0000188)    
Niddm26 Non-insulin dependent diabetes mellitus QTL 26 blood glucose amount   (VT:0000188)    
Niddm27 Non-insulin dependent diabetes mellitus QTL 27 blood glucose amount   (VT:0000188)    
Niddm28 Non-insulin dependent diabetes mellitus QTL 28 blood glucose amount   (VT:0000188)    
Niddm29 Non-insulin dependent diabetes mellitus QTL 29 blood glucose amount   (VT:0000188)    
Niddm30 Non-insulin dependent diabetes mellitus QTL 30 blood glucose amount   (VT:0000188)    
Niddm31 Non-insulin dependent diabetes mellitus QTL 31 blood glucose amount   (VT:0000188)    
Niddm32 Non-insulin dependent diabetes mellitus QTL 32 blood glucose amount   (VT:0000188)    
Niddm52 Non-insulin dependent diabetes mellitus QTL 52 blood glucose amount   (VT:0000188)    
Niddm53 Non-insulin dependent diabetes mellitus QTL 53 blood glucose amount   (VT:0000188)    
Niddm54 Non-insulin dependent diabetes mellitus QTL 54 blood glucose amount   (VT:0000188)    
Niddm55 Non-insulin dependent diabetes mellitus QTL 55 blood glucose amount   (VT:0000188)    
Niddm56 Non-insulin dependent diabetes mellitus QTL 56 blood glucose amount   (VT:0000188)    
Pancm5 Pancreatic morphology QTL 5 pancreas mass   (VT:0010144)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
F344/DuCrlCrlj (KyushuU) 1226


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems Neural tumors were seen after 60mg/kg ENU was given to pregnant rats. 2316901

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-29 F344/DuCrlCrlj    F344/DuCrlCrlj    Name updated 68913 APPROVED
2012-05-29 F344/DuCrlCrlj    F344/DuCrlCrlj    Name updated 68913 APPROVED