Strain Report - Rat Genome Database

Name: BBDR.LA-( D5Rat98-D5Rat233 )/Rhw
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: BBDR.LA-(D5Rat98-D5Rat233)/Rhw

Symbol:

BBDR.LA-(D5Rat98-D5Rat233)/Rhw

Strain:

BBDR.LA-(D5Rat98-D5Rat233)

Substrain:

Rhw

RGD ID:

6893530

Citation ID:

RRID:RGD_6893530

Ontology ID:

RS:0003305

Previously known as:

DR.^lepr; DR.lepr; BBDR.^lepr; BBDR.lepr; BBDR.LA-(D5Rat98-D5Rat233)/Rhw

Type:

congenic

Source:

R. H. William Laboratory, University of Washington, Seattle, Washington

Origin:

Koletsky rat leptin receptor mutant (lepr) from the LA/N-cp was introgressed into the BBDR/Rhw rats by marker-assisted breeding. This was initiated in 2001 by Dr. Hansen and completed in 2007 at the University of Washington, Seattle.

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	95,774,194 - 118,714,492	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	5	99,421,434 - 123,480,464	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	5	103,451,053 - 127,341,295	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	5	100,017,060 - 124,932,061	RGD_MAPPER_PIPELINE	RGSC3.4

Congenic Strains

BBDR.LA-(D5Rat98-D5Rat233), BBDP-(D4Mit6-D4Mit7)/Rhw

BBDR.LA-(D5Rhw23-D5Rhw20)/ULUND

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hyperglycemia (IAGP)

obesity (IAGP)

type 2 diabetes mellitus (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal pancreatic islet morphology (IAGP)

decreased lymphocyte cell number (IAGP)

increased body weight (IAGP)

increased circulating cholesterol level (IAGP)

increased circulating glucose level (IAGP)

increased circulating insulin level (IAGP)

increased circulating leptin level (IAGP)

increased gonadal fat pad weight (IAGP)

increased mesenteric fat pad weight (IAGP)

increased retroperitoneal fat pad weight (IAGP)

increased susceptibility to non-insulin-dependent diabetes (IAGP)

obese (IAGP)

pancreas inflammation (IAGP)

pancreatic islet hyperplasia (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats.	Moralejo DH, etal., Physiol Genomics. 2010 Mar 3;41(1):9-20. Epub 2009 Dec 8.
2.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D5Rat98)

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	95,774,194 - 95,774,399 (+)	MAPPER
Rnor_6.0	5	99,421,434 - 99,421,638	NCBI
Rnor_5.0	5	103,451,053 - 103,451,257	UniSTS
RGSC_v3.4	5	100,017,061 - 100,017,265	UniSTS
RGSC_v3.4	5	100,017,060 - 100,017,265	RGD
RGSC_v3.1	5	100,022,287 - 100,022,491	RGD
Celera	5	94,344,392 - 94,344,614	UniSTS
RH 3.4 Map	5	724.1	RGD
RH 3.4 Map	5	724.1	UniSTS
RH 2.0 Map	5	603.7	RGD
SHRSP x BN Map	5	53.5899	RGD
Cytogenetic Map	5	q31	UniSTS

Flank 2 / 1 (D5Rat233)

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	5	118,714,244 - 118,714,492 (+)	MAPPER
Rnor_6.0	5	123,480,217 - 123,480,464	NCBI
Rnor_5.0	5	127,341,048 - 127,341,295	UniSTS
RGSC_v3.4	5	124,931,813 - 124,932,061	RGD
RGSC_v3.4	5	124,931,814 - 124,932,061	UniSTS
RGSC_v3.1	5	124,937,039 - 124,937,287	RGD
Celera	5	117,279,540 - 117,279,787	UniSTS
SHRSP x BN Map	5	63.7699	RGD
SHRSP x BN Map	5	63.7699	UniSTS

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_characteristics	heterozygous lepr (-/+)or homozygous BBDR (-/-) were lean and metabolically normal	6893459

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2012-09-05	BBDR.LA-(D5Rat98-D5Rat233)Rhw	BBDR.LA-(D5Rat98-D5Rat233)Rhw	Name updated	68913	APPROVED
2012-09-05	BBDR.LA-(D5Rat98-D5Rat233)/Rhw	BBDR.LA-(D5Rat98-D5Rat233)Rhw	Symbol updated	68687	APPROVED
2012-09-05	BBDR.LA-(D5Rat98-D5Rat233)/Rhw	BBDR.LA-(D5Rat98-D5Rat233)Rhw	Name updated	68913	APPROVED
2012-09-05	BBDR.LA-(D5Rat98-D5Rat233)/Rhw	BBDR.LA-(D5Rat98-D5Rat233)Rhw	Symbol updated	68687	APPROVED
2012-09-05	BBDR.LA-(D5Rat98-D5Rat233)/Rhw	BBDR.LA-(D5Rat98-D5Rat233)Rhw	Name updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: BBDR.LA-(D5Rat98-D5Rat233)/Rhw

Mammalian Phenotype