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Strain Registration

Strain: SS-Hvcn1em2Mcwi-/-

Symbol: SS-Hvcn1em2Mcwi-/-
Strain: SS-Hvcn1em2-/-
Substrain: Mcwi
RGD ID: 6893439
Citation ID: RRID:RGD_6893439
Ontology ID: RS:0003319
Alleles: Hvcn1em2Mcwi
Previously known as: SS-Hvcn1em2Mcwi; SS-Hvcn1em2Mcwi
Type: mutant
Source: PhysGen Knockouts
Origin: This strain was produced by injecting ZFNs targeting the sequence CACACCCAGGCCATCCCTGgacttCAGGAGCCGGCTAAGGAA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 8-bp deletion in exon 5.
Genetic Status: Homozygous
Last Known Status: Cryopreserved Sperm (as of 2017-01-26)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,341,673 - 34,370,010RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01239,822,814 - 39,851,093RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01241,702,567 - 41,731,349RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41235,536,954 - 35,556,666RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na+ /H+ exchanger-1 antagonism. Li W, etal., Physiol Rep. 2019 Aug;7(13):e14142. doi: 10.14814/phy2.14142.
3. PhysGen Knockouts PhysGen Knockout strains
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-06 SS-Hvcn1em2Mcwi-/-    SS-Hvcn1em2Mcwi    Symbol and/or name change 68913 APPROVED
2014-04-03 SS-Hvcn1em2Mcwi    SS-Hvcn1em2Mcwi    Symbol updated 68687 APPROVED
2014-04-03 SS-Hvcn1em2Mcwi    SS-Hvcn1em2Mcwi    Name updated 68913 APPROVED
2014-04-03 SS-Hvcn1em2Mcwi    SS-Hvcn1em2Mcwi    Name updated 68913 APPROVED
2014-04-03 SS-Hvcn1em2Mcwi    SS-Hvcn1em2Mcwi    Symbol updated 68687 APPROVED
2013-08-15 SS-Hvcn1em2Mcwi    SS-Hvcn1em2Mcwi    Name updated 68913 APPROVED
2012-09-12 SS-Hvcn1em2Mcwi    SS-Hvcn1em2Mcwi    Name updated 68913 APPROVED
2012-09-12 SS-Hvcn1em2Mcwi    SS-Hvcn1em2Mcwi    Name updated 68913 APPROVED