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Strain Registration

Strain: HTX/Hcj

Symbol: HTX/Hcj
Strain: HTX
Substrain: Hcj
RGD ID: 68189
Citation ID: RRID:RGD_68189
Ontology ID: RS:0000386
Previously known as: H-Tx/Hcj
Type: inbred
Source: Department of Pharmacology, University of Florida, Gainesville.
Origin: D. F. Kohn, Inst. of Comparative Medicine,Columbia University, to University of Florida 1992 at F30.
Coat Color: Albino
Inbred Generations: F48 but re-derived in 1997,rederived rats F8
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View
hydrocephalus  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
hydrocephaly  (IAGP)

References

References - curated
# Reference Title Reference Citation
1. Genetic analysis of inherited hydrocephalus in a rat model. Jones HC, etal., Exp Neurol 2004 Nov;190(1):79-90.
2. Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat. Jones HC, etal., Mamm Genome 2001 Jan;12(1):22-6.
3. Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat. Jones HC, etal., Mamm Genome 2001 Jan;12(1):22-6.
4. A new model of congenital hydrocephalus in the rat. Kohn DF, etal., Acta Neuropathol (Berl). 1981;54(3):211-8.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Bvd1 Brain ventricular dilatation QTL 1 brain ventricle morphology trait   (VT:0000822)    
Bvd2 Brain ventricular dilatation QTL 2 brain ventricle morphology trait   (VT:0000822)    
Bvd3 Brain ventricular dilatation QTL 3 brain ventricle morphology trait   (VT:0000822)    
Bvd4 Brain ventricular dilatation QTL 4 brain ventricle morphology trait   (VT:0000822)    
Bvd5 Brain ventricular dilatation QTL 5 brain ventricle morphology trait   (VT:0000822)    
Bvd6 Brain ventricular dilatation QTL 6 brain ventricle morphology trait   (VT:0000822)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy Enlarged heads visible after birth in 30-50% pups 68196
strain_life_disease Hydrocephalus due to excess cerebrospinal fluid leading to brain damage. Survival 4-6 weeks for hydrocephalic rats 68196
strain_phys_biochem Raised intracranial pressure by 3 weeks of ages 68196
strain_reproduction Mean litter size is 9 68196