Strain Report - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Strain: LA/N-cp

Symbol: LA/N-cp
Strain: LA-cp
Substrain: N
RGD ID: 68063
Citation ID: RRID:RGD_68063
Ontology ID: RS:0000421
Also Known As: LA/N-cp; LA/N-cp
Type: congenic
Available Source: NIH Autoimmune Rat Model Repository and Development Center
Origination: NIH Autoimmune Rat Model Repository and Development Center
Description: The corpulent (LA/N-cp) rat developed at the National Institutes of Health (NIH) is a congenic strain initially derived by mating a male Koletsky rat that was heterozygous for the corpulent gene (cp/ +) to a female Lister Albany/NIH (LAIN) rat. The obese homozygous (cp/cp) littermates developspontaneous insulin resistance, obesity, impaired glucose tolerance, hypertriglyceridemia and atherosclerosis.
Genetic Markers: a,H.
Coat Color: Black
Inbred Generations: F89 (NIH 1989)
Last Known Status: Unknown

Congenic Strains
LA-cp/NJcr
LA-cp/NRll
Mutant Strains
LA-cp/NRll





References

References - curated
# Reference Title Reference Citation
1. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2. Rat Strain List M. Festing Rat Strain List
3. Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats. Moralejo DH, etal., Physiol Genomics. 2010 Mar 3;41(1):9-20. Epub 2009 Dec 8.
4. NIH Rat Strain Data NIH Rat Strain Data
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Good reproductive performance. LA is mainly used as control for congenic strain LA/N-cp (ie carrying the corpulent gene, an allele of fatty) in studies of obesity (see Tulp 1990 for a review).High 10-week body weight in males (21/23) (Tanase et al 1982). Low relative heart weight in10-week old males (1/23) (Tanase et al 1982). Diabetes in LA/N-cp occurs in 80% of male obese and 17% of female obese rats from six months of age (Tulp and Weng, 1992). Glucose turnover in lean and obese LA rats has been described by Berdanier et al, (1993). Obese rats have twice the capacity to synthesise body fat and cholesterol, but have a reduced capacity todegrade cholesterol, leading to an accumulation of cholesterol and fat (Ghosh et al, 1995). 634612
strain_characteristics This congenic strain is derived from Koletsky rat and has a mutation in the leptin receptor gene that is inherited as a single homozygous recessive trait. 6893459

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-21   LA/N-cp    Symbol and/or name change 68913 APPROVED