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Strain Registration

Strain: SS-Nr2f2em1Mcwi

Symbol: SS-Nr2f2em1Mcwi
Strain: SS-Nr2f2em1
Substrain: Mcwi
RGD ID: 6484583
Citation ID: RRID:RGD_6484583
Ontology ID: RS:0003277
Alleles: Nr2f2em1Mcwi
Also Known As: SS-Nr2f2em1Mcwi; SS-Nr2f2^[em1Mcwi]
Type: mutant
Available Source: Not Available
Origination: PhysGen Knockouts
Description: This strain was produced by injecting ZFNs targeting the sequence CCTTCTTCCCTGACCTGCagatcACGGACCAGGTGGCC into SS/JrHsdMcwi rat embryos. The resulting mutation is a 15-bp frameshift deletion in exon 2.
Last Known Status: Cryopreserved Sperm (as of 2017-01-26)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81133,419,161 - 133,434,290RGD_MAPPER_PIPELINE
mRatBN7.21124,013,926 - 124,013,940RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01131,452,414 - 131,452,428RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01132,486,697 - 132,499,845RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41125,280,974 - 125,286,929RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View
hypertension  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. Mutation within the hinge region of the transcription factor Nr2f2 attenuates salt-sensitive hypertension. Kumarasamy S, etal., Nat Commun. 2015 Feb 17;6:6252. doi: 10.1038/ncomms7252.
3. PhysGen Knockouts PhysGen Knockout strains
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Nr2f2em1Mcwi-var1 chr1 124013926 124013940 CTGCCCGTGAGTAGG - deletion mRatBN7.2
Nr2f2em1Mcwi-var1 chr1 131452414 131452428 CTGCCCGTGAGTAGG - deletion Rnor_6.0

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-03 SS-Nr2f2em1Mcwi    SS-Nr2f2em1Mcwi    Symbol updated 68687 APPROVED
2014-04-03 SS-Nr2f2em1Mcwi    SS-Nr2f2em1Mcwi    Symbol updated 68687 APPROVED
2014-04-03 SS-Nr2f2em1Mcwi    SS-Nr2f2em1Mcwi    Name updated 68913 APPROVED
2014-04-03 SS-Nr2f2em1Mcwi    SS-Nr2f2em1Mcwi    Name updated 68913 APPROVED
2013-08-15 SS-Nr2f2em1Mcwi    SS-Nr2f2em1Mcwi    Name updated 68913 APPROVED
2013-08-15 SS-Nr2f2em1Mcwi    SS-Nr2f2em1Mcwi    Name updated 68913 APPROVED