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Strain Registration

Strain: SS-Resp18em2Mcwi

Symbol: SS-Resp18em2Mcwi
Strain: SS-Resp18em2
Substrain: Mcwi
RGD ID: 6484581
Citation ID: RRID:RGD_6484581
Ontology ID: RS:0003275
Alleles: Resp18em2Mcwi
Also Known As: SS-Resp18em2Mcwi; SS-Resp18^[em2Mcwi]
Type: mutant
Available Source: Not Available
Origination: PhysGen Knockouts
Description: This strain was produced by injecting ZFNS targeting the sequence CTCAGCAGACTCCATCCCCagtatcCATGCCGGAAGGAGGGGAA into SS/JrHsdMcwi rat embryos. The resulting mutation is a 7-bp deletion in exon 3.
Last Known Status: Cryopreserved Sperm (as of 2017-01-26)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8984,213,844 - 84,220,186RGD_MAPPER_PIPELINE
mRatBN7.2976,767,473 - 76,767,479RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0982,470,794 - 82,477,136RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0982,240,055 - 82,246,695RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4974,551,809 - 74,558,151RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Deep transcriptomic profiling of Dahl salt-sensitive rat kidneys with mutant form of Resp18. Ashraf UM, etal., Biochem Biophys Res Commun. 2021 Oct 1;572:35-40. doi: 10.1016/j.bbrc.2021.07.071. Epub 2021 Jul 30.
2. Intrarenal Dopaminergic System Is Dysregulated in SS-Resp18mutant Rats. Ashraf UM, etal., Biomedicines. 2023 Jan 1;11(1):111. doi: 10.3390/biomedicines11010111.
3. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
4. Targeted disruption of regulated endocrine-specific protein ( Resp18) in Dahl SS/Mcw rats aggravates salt-induced hypertension and renal injury. Kumarasamy S, etal., Physiol Genomics. 2018 May 1;50(5):369-375. doi: 10.1152/physiolgenomics.00008.2018. Epub 2018 Mar 23.
5. PhysGen Knockouts PhysGen Knockout strains
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Resp18em2Mcwi-var1 chr9 76767473 76767479 TGGATAC - deletion mRatBN7.2

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-03 SS-Resp18em2Mcwi    SS-Resp18em2Mcwi    Name updated 68913 APPROVED
2014-04-03 SS-Resp18em2Mcwi    SS-Resp18em2Mcwi    Symbol updated 68687 APPROVED
2014-04-03 SS-Resp18em2Mcwi    SS-Resp18em2Mcwi    Name updated 68913 APPROVED
2014-04-03 SS-Resp18em2Mcwi    SS-Resp18em2Mcwi    Symbol updated 68687 APPROVED
2013-08-15 SS-Resp18em2Mcwi    SS-Resp18em2Mcwi    Name updated 68913 APPROVED