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Strain Registration

Strain: LEH/Hkv

Symbol: LEH/Hkv
Strain: LEH
Substrain: Hkv
Full Name: Aganglionosis rat
RGD ID: 6480220
Citation ID: RRID:RGD_6480220
Ontology ID: RS:0003209
Alleles: Ednrbsl
Also Known As: LEH/Hkv-Ednrbsl; LEH/Hkv-Ednrbsl; LE/Hkv.AR-Ednrbsl; LEH.AR-Ednrbsl/Hkv; NBRP Rat No: 0802; LEH.AR-Ednrbsl/Hkv; LE/Hkv.AR-Ednrbsl; LE.AR-Ednrbsl/OkkmHkv
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido, Japan
Description: This strain derived from AR (aganglionosis) rat found by Dr. Ikadai in 1973. AR-derived Ednrbsl was introduced into Long-Evans by Dr. Ozaki (NBRP-Rat # 0557 LE.AR-EdnrbSl/Okkm), and this rat was provided to Dr. Agui at Hokkaido University and inbred line was established by sib mating.
Inbred Generations: F21
Last Known Status: Cryopreserved Embryo (as of 2016-11-15)
Research Usage Internal Medicine
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21580,670,748 - 80,671,048RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01588,034,987 - 88,035,287RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01591,500,400 - 91,531,979RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41587,893,141 - 87,898,700RGD_MAPPER_PIPELINERGSC3.4

Congenic Strains
LE;LEH-Ednrbsl/Kwb




Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table


References

References - curated
# Reference Title Reference Citation
1. QTL analysis identifies a modifier locus of aganglionosis in the rat model of Hirschsprung disease carrying Ednrb(sl) mutations. Dang R, etal., PLoS One. 2011;6(11):e27902. Epub 2011 Nov 22.
2. Genetic background strongly modifies the severity of symptoms of Hirschsprung disease, but not hearing loss in rats carrying Ednrb(sl) mutations. Dang R, etal., PLoS One. 2011;6(9):e24086. Epub 2011 Sep 7.
3. Identification of genetic loci affecting the severity of symptoms of Hirschsprung disease in rats carrying Ednrbsl mutations by quantitative trait locus analysis. Huang J, etal., PLoS One. 2015 Mar 19;10(3):e0122068. doi: 10.1371/journal.pone.0122068. eCollection 2015.
4. QTL analysis of modifiers for pigmentary disorder in rats carrying Ednrb(sl) mutations. Huang J, etal., Sci Rep. 2016 Jan 22;6:19697. doi: 10.1038/srep19697.
5. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Coatc10 Coat color QTL 10 coat/hair pigmentation trait   (VT:0010463)    
Coatc11 Coat color QTL 11 coat/hair pigmentation trait   (VT:0010463)    
Coatc12 Coat color QTL 12 coat/hair pigmentation trait   (VT:0010463)    
Coatc13 Coat color QTL 13 coat/hair pigmentation trait   (VT:0010463)    
Coatc14 Coat color QTL 14 coat/hair pigmentation trait   (VT:0010463)    
Coatc15 Coat color QTL 15 coat/hair pigmentation trait   (VT:0010463)    
Coatc16 Coat color QTL 16 coat/hair pigmentation trait   (VT:0010463)    
Coatc6 Coat color QTL 6 coat/hair pigmentation trait   (VT:0010463)    
Coatc7 Coat color QTL 7 coat/hair pigmentation trait   (VT:0010463)    
Coatc8 Coat color QTL 8 coat/hair pigmentation trait   (VT:0010463)    
Coatc9 Coat color QTL 9 coat/hair pigmentation trait   (VT:0010463)    
Gdil2 Gastrointestinal dilation QTL 2 enteric ganglion morphology trait   (VT:0001045)    
Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Ednrbsl-var1 chr15 80670748 80671048 CCCACCCCTGGTTTCCAGACCTGCAGATCACTATCAGGTACGTTACCTTGTAGGCATTAATGGGAATGTCGATGATGATGTGTAGCAGATCTCCCAGAGCCAGGCTGGCGATCAAGATATTGGGACCATTTCTCATGCACTTGTTCTTGTAGATGATTCTTAGCAGTGTGGAGTTCCCGATGATGCCTAGCACGAACACGAGGCATGATACAATCGTGTTGATGTATTTAAAAGTCTTGTTGATCTCAATTTTTCGTTGGCACGGAGGAGGGAAGGATCTTGGCGGGACTCCAGCCACCCT - deletion mRatBN7.2
Ednrbsl-var1 chr15 88034987 88035287 CCCACCCCTGGTTTCCAGACCTGCAGATCACTATCAGGTACGTTACCTTGTAGGCATTAATGGGAATGTCGATGATGATGTGTAGCAGATCTCCCAGAGCCAGGCTGGCGATCAAGATATTGGGACCATTTCTCATGCACTTGTTCTTGTAGATGATTCTTAGCAGTGTGGAGTTCCCGATGATGCCTAGCACGAACACGAGGCATGATACAATCGTGTTGATGTATTTAAAAGTCTTGTTGATCTCAATTTTTCGTTGGCACGGAGGAGGGAAGGATCTTGGCGGGACTCCAGCCACCCT - deletion Rnor_6.0

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy abnormal dilation of the intestines due to absence of ganglion cells is observed in 14 days postnatal rats (shorter as compared to AR-EdnrbSlHkv 10402048
strain_characteristics Homozygous rats show auditory disorder (congenital deafness) and die of megacolon. This strain can survive longer than AGH rat and shows milder phenotype. Heterozygous (sl/+) rats don't show any phenotypes. 1302502
strain_reproduction maintained in heterozygous condition 1302502

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-21 LEH/Hkv  Aganglionosis rat  LE.AR-Ednrbsl/OkkmHkv  Aganglionosis rat  Symbol and/or name change 68913 APPROVED
2023-06-08 LE.AR-Ednrbsl/OkkmHkv  Aganglionosis rat  LE/Hkv.AR-Ednrbsl  Aganglionosis rat  Symbol and/or name change 68913 APPROVED
2017-05-01 LE/Hkv.AR-Ednrbsl  Aganglionosis rat  LEH/Hkv.AR-Ednrbsl  Aganglionosis rat  Symbol updated 68687 APPROVED
2016-11-15 LEH/Hkv.AR-Ednrbsl  Aganglionosis rat  LEH/Hkv.AR-Ednrbsl  Aganglionosis rat  Symbol updated 68687 APPROVED
2016-11-15 LEH/Hkv.AR-Ednrbsl  Aganglionosis rat  LEH.AR-EdnrbslHkv  Aganglionosis rat  Symbol updated 68687 APPROVED
2016-04-22 LEH.AR-EdnrbslHkv  Aganglionosis rat  LE.AR-EdnrbslHkv  Aganglionosis rat  Symbol updated 68687 APPROVED
2016-04-22 LE.AR-EdnrbslHkv  Aganglionosis rat  LE-EdnrbSlHkv  Aganglionosis rat  Symbol updated 68687 APPROVED
2012-03-16 LE-EdnrbSlHkv  Aganglionosis rat  LE-EdnrbSlHkv  Aganglionosis rat  Name updated 68913 APPROVED