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Strain Registration

Strain: STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc

Symbol: STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc
Strain: STOCK-Tp53tm1(EGFP-Pac)Qly
Substrain: QlyRrrc
Full Name: p53 knockout rat
RGD ID: 6478788
Citation ID: RRID:RRRC_00485
Ontology ID: RS:0003202
Alleles: Tp53tm1(EGFP-Pac)Qly;   Tp53
Previously known as: STOCK-Tp53tm1(EGFP-Pac)QlyRrrc; STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc
Type: mutant
Source: Rat Resource and Research Center
Origin: This strain was made by electroporation of DAc8 embryonic stem cells with a targeting vector containing 6.7kb 5 prime and 1.6- kb 3 prime homology arms and a CAG-EGFP-IRES-Pac cassette. Chimeras were formed by microinjecting F344 blastocysts. Founder animals were mated with SD rats.
Coat Color: albino
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2019-02-01)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,300,070 - 54,311,525RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01056,186,299 - 56,198,449RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01055,932,658 - 55,944,087RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41056,399,721 - 56,411,150RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Production of p53 gene knockout rats by homologous recombination in embryonic stem cells. Tong C, etal., Nature. 2010 Sep 9;467(7312):211-3. Epub 2010 Aug 11.
4. Rats deficient for p53 are susceptible to spontaneous and carcinogen-induced tumorigenesis. Yan HX, etal., Carcinogenesis. 2012 Oct;33(10):2001-5. doi: 10.1093/carcin/bgs238. Epub 2012 Jul 12.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Absence of Tp53 protein was confirmed by western blot in homozygous animals. Homozygotes die at an early age; most will develop neoplasia by 4 months of age. Heterozygous animals may also develop neoplasia. Very little clinical signs are seen prior to death and twice a day monitoring maybe needed to detect animals with neoplastic disease symptoms prior to death. Most clinical findings are related to acute blood loss from hemorrhage (hemangiosarcomas are common) or seizure activity/neurologic signs due to brain or spinal cord tumors. 2292495
strain_reproduction random intra-strain mating 2292495

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-22 STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc  p53 knockout rat  STOCK-Tp53tm1(EGFP-Pac)QlyRrrc  p53 knockout rat  Symbol updated 68687 APPROVED
2015-10-22 STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc  p53 knockout rat  STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc  p53 knockout rat  Symbol updated 68687 APPROVED
2014-03-31 STOCK-Tp53tm1(EGFP-Pac)QlyRrrc  p53 knockout rat  STOCK-Tp53tm1(EGFP-Pac)QlyRrrc  p53 knockout rat  Symbol updated 68687 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00485 RGD