Strain Report - Rat Genome Database

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Strain: GHS

Symbol: GHS
Strain: GHS
RGD ID: 634372
Citation ID: RRID:RGD_634372
Ontology ID: RS:0001315
Type: inbred
Source: Department of Medicine and Physiology, University of Rochester, Rochester, New York
Origin: SD rats were selectively bred for hypercalciuria through four generations to create the genetic hypercalciuric strain.
Inbred Generations: F4
Last Known Status: Unknown





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Mammalian Phenotype

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Clinical Measurement
urine calcium excretion rate

References

References - curated
# Reference Title Reference Citation
1. Quantitative trait loci for hypercalciuria in a rat model of kidney stone disease. Hoopes RR Jr, etal., J Am Soc Nephrol 2003 Jul;14(7):1844-50.
2. Isolation and confirmation of a calcium excretion quantitative trait locus on chromosome 1 in genetic hypercalciuric stone-forming congenic rats. Hoopes RR Jr, etal., J Am Soc Nephrol. 2006 May;17(5):1292-304. Epub 2006 Apr 12.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Hyperresponsiveness of vitamin D receptor gene expression to 1,25-dihydroxyvitamin D3. A new characteristic of genetic hypercalciuric stone-forming rats. Yao J, etal., J Clin Invest. 1998 May 15;101(10):2223-32.

Region

Strain QTL Data
Symbol Name Trait
Hc1 Hypercalciuria QTL 1 urine calcium amount   (VT:0002985)    
Hc2 Hypercalciuria QTL 2 urine calcium amount   (VT:0002985)    
Hc3 Hypercalciuria QTL 3 urine calcium amount   (VT:0002985)    
Hc4 Hypercalciuria QTL 4 urine calcium amount   (VT:0002985)    
Hc5 Hypercalciuria QTL 5 urine calcium amount   (VT:0002985)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem Dysregulation of calcium homeostasis is observed; these animals absorb high amounts of dietary calcium and fail to reabsorb filtered calcium. 1582396