Strain Report - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Strain: SHR/OlaIpcv

Symbol: SHR/OlaIpcv
Strain: SHR
Substrain: OlaIpcv
RGD ID: 631848
Citation ID: RRID:RGD_631848
Ontology ID: RS:0000715
Alleles: Sbf1m1Ipcv
Previously known as: MDC-01-25;MDC-01-25-2
Type: inbred
Source: Czech Academy of Sciences, Prague, Czech Republic
Origin: These are descendents of SHR which were originally from National Institutes of Health. It has been maintained by brother x sister mating at the Czech Academy of Sciences for more than 15 years. A spontaneous recessive mutation in intron 37 (-1 of exon 38) of Sbf1 was identified in this strain.
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View


References

References - curated
# Reference Title Reference Citation
1. The genome sequence of the spontaneously hypertensive rat: Analysis and functional significance. Atanur SS, etal., Genome Res. 2010 Apr 29.
2. Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat. Johnson MD, etal., Hypertension. 2009 Sep;54(3):639-45. Epub 2009 Jul 20.
3. Recent advances in genetics of the spontaneously hypertensive rat. Pravenec M and Kurtz TW, Curr Hypertens Rep. 2010 Feb;12(1):5-9.
4. Insight into the genetics of hypertension, a core component of the metabolic syndrome. Pravenec M and Petretto E, Curr Opin Clin Nutr Metab Care. 2008 Jul;11(4):393-7.
5. Genetic isolation of a blood pressure quantitative trait locus on chromosome 2 in the spontaneously hypertensive rat. Pravenec M, etal., J Hypertens 2001 Jun;19(6):1061-4.
6. Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats. Pravenec M, etal., Nat Genet 2001 Feb;27(2):156-8.
7. Genetic isolation of quantitative trait loci for blood pressure development and renal mass on chromosome 5 in the spontaneously hypertensive rat. Pravenec M, etal., Physiol Res 2003;52(3):285-9.
8. Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity. Pravenec M, etal., Physiol Res. 2017 Dec 20;66(6):917-924. doi: 10.33549/physiolres.933811.
9. RGD Strain RSO annotation pipeline RGD Automated Pipelines
10. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
11. Rat inbred PD/cub strain as a model of dyslipidemia and insulin resistance. Sedova L, etal., Folia Biol (Praha) 2000;46(3):99-106.
12. Mapping of quantitative trait loci for seminal vesicle mass and litter size to rat chromosome 8. Zidek V, etal., J Reprod Fertil 1999 Jul;116(2):329-33.

Region

Strain QTL Data
Symbol Name Trait
Inf1 Infertility severity QTL 1 seminal gland mass   (VT:0010524)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
SHR/OlaIpcv (ICL) 648
SHR/OlaIpcv (KNAW) 619
SHR/OlaIpcv (ICL) 765
SHR/OlaIpcv (KNAW) 908


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem Hypertension, fatty acid metabolism and transmission of insulin resistance is linked to a spontaneous Cd36 deletion 68930