Strain Report - Rat Genome Database

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Strain: F344.GK-(D1Mit7-D1Mgh25)/Swe

Symbol: F344.GK-(D1Mit7-D1Mgh25)/Swe
Strain: F344.GK-(D1Mit7-D1Mgh25)
Substrain: Swe
RGD ID: 631847
Citation ID: RRID:RGD_631847
Ontology ID: RS:0000283
Also Known As: F344.GK-(D1Mit7-D1Mgh25); f344-gk-niddm1f; F344.GK-(D1Mit7-D1Mgh25)/Swe
Type: congenic
Available Source: Not Available
Origination: Karolinska Institute
Description: Congenic strain originated from an inbred F344 strain
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21229,550,480 - 229,550,676RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01250,195,095 - 250,195,290RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01257,430,524 - 262,617,374RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41235,677,487 - 240,980,321RGD_MAPPER_PIPELINERGSC3.4

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. Fakhrai-Rad H, etal., Hum Mol Genet 2000 Sep 1;9(14):2149-58.
2. Pathophysiological and genetic characterization of the major diabetes locus in GK rats. Galli J, etal., Diabetes 1999 Dec;48(12):2463-70.
3. Separately inherited defects in insulin exocytosis and beta-cell glucose metabolism contribute to type 2 diabetes. Granhall C, etal., Diabetes. 2006 Dec;55(12):3494-500.
4. Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats. Lin JM, etal., Diabetes 2001 Dec;50(12):2737-43.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Position Markers

Flank 1 / 1 (D1Mit7)
Rat AssemblyChrPosition (strand)Source
Rnor_5.01262,617,194 - 262,617,374NCBI
RGSC_v3.41240,980,142 - 240,980,321RGD
RGSC_v3.11241,163,531 - 241,163,920RGD
Cytogenetic Map1 RGD

Flank 2 / 1 (D1Mgh25)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21229,550,480 - 229,550,676 (+)MAPPER
Rnor_6.01250,195,095 - 250,195,290NCBI
Rnor_5.01257,430,524 - 257,430,719UniSTS
RGSC_v3.41235,677,487 - 235,677,683RGD
RGSC_v3.41235,677,488 - 235,677,683UniSTS
RGSC_v3.11235,841,510 - 235,841,706RGD
Celera1226,671,919 - 226,672,114UniSTS
Cytogenetic Map1q52UniSTS
Strain QTL Data
Symbol Name Trait
Niddm36 Non-insulin dependent diabetes mellitus QTL 36 insulin secretion trait   (VT:0003564)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These rats do not have any major defects in insulin secretion. 619688