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Strain: Iusm:LAD1

Symbol: Iusm:LAD1
Strain: LAD1
Substrain: Iusm
Full Name: low-alcohol-drinking
RGD ID: 631845
Citation ID: RRID:RGD_631845
Ontology ID: RS:0000423
Also Known As: LAD1
Type: outbred
Available Source: Not Available
Origination: Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana
Description: These low-alcohol-drinking were developed by selective breeding from the heterogeneous strain N:NIH (RGD:728185). 8 inbred rat strains were intercrossed for alcohol preference and consumption. Within-family selection and a rotational breeding design were employed to reduce inbreeding and to allow maintenance of non-inbred replicate lines. Replicate lines were independently selected for low alcohol drinking (LAD1 and LAD2).
Last Known Status: Unknown

Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Iusm:LAD1RatIusm:LAD1  IEA 7241799 RGD 

Vertebrate Trait
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Iusm:LAD1Ratconsumption behavior trait  EXP 631230 RGD 
Iusm:LAD1Ratconsumption behavior trait  EXP 724636 RGD 
Iusm:LAD1Ratconsumption behavior trait  EXP 731212 RGD 


References - curated
# Reference Title Reference Citation
1. Analyses of quantitative trait loci contributing to alcohol preference in HAD1/LAD1 and HAD2/LAD2 rats. Carr LG, etal., Alcohol Clin Exp Res 2003 Nov;27(11):1710-7.
2. Identification of quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinking rat lines. Foroud T, etal., Behav Genet 2000 Mar;30(2):131-40.
3. Confirmation of alcohol preference quantitative trait loci in the replicate high alcohol drinking and low alcohol drinking rat lines. Foroud T, etal., Psychiatr Genet 2003 Sep;13(3):155-61.
4. Alcohol preference and voluntary alcohol intakes of inbred rat strains and the National Institutes of Health heterogeneous stock of rats. Li TK and Lumeng L, Alcohol Clin Exp Res. 1984 Sep-Oct;8(5):485-6. doi: 10.1111/j.1530-0277.1984.tb05708.x.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Strain QTL Data
Symbol Name Trait
Alc10 Alcohol consumption QTL 10 consumption behavior trait   (VT:0002069)    
Alc11 Alcohol consumption QTL 11 consumption behavior trait   (VT:0002069)    
Alc4 Alcohol consumption QTL 4 consumption behavior trait   (VT:0002069)    
Alc5 Alcohol consumption QTL 5 consumption behavior trait   (VT:0002069)    
Alc6 Alcohol consumption QTL 6 consumption behavior trait   (VT:0002069)    
Alc7 Alcohol consumption QTL 7 consumption behavior trait   (VT:0002069)    
Alc9 Alcohol consumption QTL 9 consumption behavior trait   (VT:0002069)    

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-03-07 Iusm:LAD1  low-alcohol-drinking  LAD1  low-alcohol-drinking  Symbol and/or name change 68913 APPROVED