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Strain Registration

Strain: Iusm:HAD1

Symbol: Iusm:HAD1
Strain: HAD1
Substrain: Iusm
Full Name: high-alcohol-drinking
RGD ID: 631844
Citation ID: RRID:RGD_631844
Ontology ID: RS:0000389
Previously known as: HAD1; Iusd:HAD1
Type: outbred
Source: Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana
Origin: These high-alcohol-drinking rats were developed by selective breeding from the heterogeneous N/N (N:NIH) strain . 8 inbred rat strains were intercrossed for alcohol preference and consumption.Within-family selection and a rotational breeding design were employed to reduce inbreeding and to allow maintenance of non-inbred replicate lines. Replicate lines were independently selected for high alcohol drinking (HAD1 and HAD2).
Last Known Status: Unknown





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Bone mass and strength: phenotypic and genetic relationship to alcohol preference in P/NP and HAD/LAD rats. Alam I, etal., Alcohol Clin Exp Res. 2005 Oct;29(10):1769-76. doi: 10.1097/01.alc.0000183005.28502.4f.
2. Analyses of quantitative trait loci contributing to alcohol preference in HAD1/LAD1 and HAD2/LAD2 rats. Carr LG, etal., Alcohol Clin Exp Res 2003 Nov;27(11):1710-7.
3. Identification of quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinking rat lines. Foroud T, etal., Behav Genet 2000 Mar;30(2):131-40.
4. Confirmation of alcohol preference quantitative trait loci in the replicate high alcohol drinking and low alcohol drinking rat lines. Foroud T, etal., Psychiatr Genet 2003 Sep;13(3):155-61.
5. Alcohol preference and voluntary alcohol intakes of inbred rat strains and the National Institutes of Health heterogeneous stock of rats. Li TK and Lumeng L, Alcohol Clin Exp Res. 1984 Sep-Oct;8(5):485-6. doi: 10.1111/j.1530-0277.1984.tb05708.x.
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Alc10 Alcohol consumption QTL 10 consumption behavior trait   (VT:0002069)    
Alc11 Alcohol consumption QTL 11 consumption behavior trait   (VT:0002069)    
Alc4 Alcohol consumption QTL 4 consumption behavior trait   (VT:0002069)    
Alc5 Alcohol consumption QTL 5 consumption behavior trait   (VT:0002069)    
Alc6 Alcohol consumption QTL 6 consumption behavior trait   (VT:0002069)    
Alc7 Alcohol consumption QTL 7 consumption behavior trait   (VT:0002069)    
Alc9 Alcohol consumption QTL 9 consumption behavior trait   (VT:0002069)    

Additional Information

RGD Curation Notes
Note Type Note Reference
null HAD and LAD rat lines were selected from a more heterogeneous foundation stock than the Wistar founders of the alcohol-preferring and -nonpreferring rat lines; they should, therefore, display greater genetic diversity than the iP and iNP lines.  

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-03-17 Iusm:HAD1  high-alcohol-drinking  Iusd:HAD1  high-alcohol-drinking  Symbol and/or name change 68913 APPROVED
2023-03-07 Iusd:HAD1  high-alcohol-drinking  HAD1  high-alcohol-drinking  Symbol and/or name change 68913 APPROVED