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Strain Registration

Strain: SHR/FubRkb

Symbol: SHR/FubRkb
Strain: SHR
Substrain: FubRkb
RGD ID: 631696
Citation ID: RRID:RGD_631696
Ontology ID: RS:0000744
Also Known As: SHR/Rkb
Type: inbred
Available Source: Not Available
Origination: Freie Universitat Berlin
Description: Strain originated from an SHR/Fub strain obtained in 1997 at the Freie Universitat Berlin.
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table


References

References - curated
# Reference Title Reference Citation
1. Early onset albuminuria in Dahl rats is a polygenetic trait that is independent from salt loading. Poyan Mehr A, etal., Physiol Genomics 2003 Aug 15;14(3):209-16.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Protective effect of female gender on the development of albuminuria in a polygenetic rat model is further enhanced by replacement of a major autosomal QTL. Schulz A, etal., Clin Sci (Lond). 2007 Oct 22;.
4. Development of overt proteinuria in the Munich Wistar Fromter rat is suppressed by replacement of chromosome 6 in a consomic rat strain. Schulz A, etal., J Am Soc Nephrol. 2007 Jan;18(1):113-21. Epub 2006 Dec 13.
5. Genetic Loci contribute to the progression of vascular and cardiac hypertrophy in salt-sensitive spontaneous hypertension. Siegel AK, etal., Arterioscler Thromb Vasc Biol 2003 Jul 1;23(7):1211-7.
6. Genetic linkage of albuminuria and renal injury in Dahl salt-sensitive rats on a high-salt diet: Comparison with spontaneously hypertensive rats. Siegel AK, etal., Physiol Genomics 2004 Jul 8;18(2):218-25. Epub 2004 May 25.
7. Dissecting the genetic predisposition to albuminuria and endothelial dysfunction in a genetic rat model. Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384.
8. Genetic analysis of salt-sensitive hypertension in Dahl rats reveals a link between cardiac fibrosis and high cholesterol. Wendt N, etal., Cardiovasc Res. 2009 Feb 15;81(3):618-26. Epub 2008 Sep 29.

Region

Strain QTL Data
Symbol Name Trait
Bp108 Blood pressure QTL 108 arterial blood pressure trait   (VT:2000000)    
Cm10 Cardiac mass QTL 10 heart left ventricle mass   (VT:0007031)    
Cm11 Cardiac mass QTL 11 heart left ventricle mass   (VT:0007031)    
Cm12 Cardiac mass QTL 12 heart left ventricle mass   (VT:0007031)    
Cm7 Cardiac mass QTL 7 aorta mass   (VT:0002845)    
Cm8 Cardiac mass QTL 8 aorta mass   (VT:0002845)    
Cm9 Cardiac mass QTL 9 aorta mass   (VT:0002845)    
Uae13 Urinary albumin excretion QTL 13 urine albumin amount   (VT:0002871)    
Uae14 Urinary albumin excretion QTL 14 urine albumin amount   (VT:0002871)    
Uae15 Urinary albumin excretion QTL 15 urine albumin amount   (VT:0002871)    
Uae16 Urinary albumin excretion QTL 16 urine albumin amount   (VT:0002871)    
Uae17 Urinary albumin excretion QTL 17 urine albumin amount   (VT:0002871)    
Uae18 Urinary albumin excretion QTL 18 urine albumin amount   (VT:0002871)    
Uae19 Urinary albumin excretion QTL 19 urine albumin amount   (VT:0002871)    
Uae28 Urinary albumin excretion QTL 28 urine albumin amount   (VT:0002871)    
Uae29 Urinary albumin excretion QTL 29 urine albumin amount   (VT:0002871)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem susceptible to high blood pressure on a low salt diet 629621