Strain Report - Rat Genome Database

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Strain: LEW.1F

Symbol: LEW.1F
Strain: LEW.1F
RGD ID: 631581
Citation ID: RRID:RGD_631581
Ontology ID: RS:0000497
Type: inbred
Source: Zentralinstitut fur versuchstierzucht, Hannover, Germany
Origin: Originally derived by Dr. Hans J. Hedrich at Versuchstierzucht, Hannover, Germany by transgressing the RT1f haplotype into the LEW stock
Last Known Status: Unknown


References - curated
# Reference Title Reference Citation
1. MHC and non-MHC gene regulation of disease susceptibility and disease course in experimental inflammatory peripheral neuropathy. de Graaf KL, etal., J Neuroimmunol. 2004 Oct;155(1-2):73-84.
2. Both common and unique susceptibility genes in different rat strains with pristane-induced arthritis. Lu S, etal., Eur J Hum Genet 2002 Aug;10(8):475-83.
3. Genetic links between the acute-phase response and arthritis development in rats. Olofsson P, etal., Arthritis Rheum 2002 Jan;46(1):259-68.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes. Vingsbo C, etal., Am J Pathol 1996 Nov;149(5):1675-83


Strain QTL Data
Symbol Name Trait
Pia11 Pristane induced arthritis QTL 11 joint integrity trait   (VT:0010548)    
Pia12 Pristane induced arthritis QTL 12 joint integrity trait   (VT:0010548)    
Pia13 Pristane induced arthritis QTL 13 joint integrity trait   (VT:0010548)    
Pia14 Pristane induced arthritis QTL 14 joint integrity trait   (VT:0010548)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease They have a locus that regulates clinical severity in both males and females which is similar to DA. 631225
strain_life_disease This strain is susceptible to pristane induced arthritis with a incidence of 100%in females. 631225