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Strain Registration

Strain: SHR/Izm

Symbol: SHR/Izm
Strain: SHR
Substrain: Izm
RGD ID: 631577
Citation ID: RRID:RGD_631577
Ontology ID: RS:0000746
Also Known As: NBRP Rat No: 0193; MDC-02-22
Type: inbred
Available Source: National BioResource Project for the Rat in Japan, Funabashi Farm, Chiba, Japan
Origination: National BioResource Project for the Rat in Japan, Funabashi Farm, Chiba, Japan
Description: Strain originated in 1963 from outbred Wistar Kyoto rats. Bred from a male with mild hypertension, mated with a female with high blood pressure. Brother x sister mating with continued selection for high blood pressure (Okamoto 1969, Okamoto et al 1972).
Inbred Generations: F110
Last Known Status: Live Animals
Research Usage Cardio Hypertension





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
mean arterial blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart left ventricle wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
serum triglyceride level
serum total cholesterol level
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
heart left ventricle weight to body weight ratio
plasma creatinine level
serum free fatty acids level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
adipocyte maximal glucose uptake
adipocyte basal glucose uptake
absolute change in adipocyte glucose uptake
adipocyte maximal glucose uptake to basal glucose uptake ratio
absolute change in adipocyte free fatty acid secretion
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Two genomic regions of chromosomes 1 and 18 explain most of the stroke susceptibility under salt loading in stroke-prone spontaneously hypertensive rat/Izm. Gandolgor TA, etal., Hypertension. 2013 Jul;62(1):55-61. doi: 10.1161/HYPERTENSIONAHA.111.00488. Epub 2013 May 20.
2. Arterial baroreceptor reflex control of sympathetic nerve activity in the spontaneously hypertensive rat. Judy WV and Farrell SK, Hypertension. 1979 Nov-Dec;1(6):605-14. doi: 10.1161/01.hyp.1.6.605.
3. A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains. Mashimo T, etal., BMC Genet. 2006 Apr 4;7:19.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
6. Genetic mapping of quantitative trait loci influencing left ventricular mass in rats. Tsujita Y, etal., Am J Physiol Heart Circ Physiol 2000 Nov;279(5):H2062-7.
7. Enhanced sympathetic control of renal function in rats congenic for the hypertension-related region on chromosome 1. Wang T, etal., Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1055-60.
8. SYMPATHETIC REGULATION OF RENAL FUNCTION IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS CONGENIC FOR CHROMOSOME 1 BLOOD PRESSURE QUANTITATIVE TRAIT LOCI. Wang T, etal., Clin Exp Pharmacol Physiol. 2008 Jun 18;.
9. Sympathetic regulation of the renal functions in rats reciprocally congenic for chromosome 1 blood pressure quantitative trait locus. Wang T, etal., Hypertens Res. 2008 Mar;31(3):561-8.
10. Evaluation of insulin resistance linkage to rat chromosome 4 in SHR of a Japanese colony. Watanabe T, etal., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87.
11. A novel link between Slc22a18 and fat accumulation revealed by a mutation in the spontaneously hypertensive rat. Yamamoto T, etal., Biochem Biophys Res Commun. 2013 Nov 1;440(4):521-6. doi: 10.1016/j.bbrc.2013.09.096. Epub 2013 Oct 4.

Region

Strain QTL Data
Symbol Name Trait
Cm26 Cardiac mass QTL 26 heart left ventricle mass   (VT:0007031)    
Cm27 Cardiac mass QTL 27 heart left ventricle mass   (VT:0007031)    
Epfw5 Epididymal fat weight QTL 5 epididymal fat pad mass   (VT:0010421)    
Gluco11 Glucose level QTL 11 adipocyte glucose uptake trait   (VT:0004185)    
Gluco12 Glucose level QTL12 adipocyte glucose uptake trait   (VT:0004185)    
Stl19 Serum triglyceride level QTL 19 blood triglyceride amount   (VT:0002644)    
Strs4 Sensitivity to stroke QTL 4 cerebrum integrity trait   (VT:0010549)    
Strs5 Sensitivity to stroke QTL 5 cerebrum integrity trait   (VT:0010549)    
Strs6 Sensitivity to stroke QTL 6 cerebrum integrity trait   (VT:0010549)    
Strs7 Sensitivity to stroke QTL 7 cerebrum integrity trait   (VT:0010549)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These are spontaneously hypertensive rats. 619658

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-30 SHR/Izm    SHR/Izm    Name updated 68913 APPROVED
2014-04-30 SHR/Izm    SHR/Izm    Name updated 68913 APPROVED
2012-05-10 SHR/Izm    SHR/Izm    Name updated 68913 APPROVED
2012-05-10 SHR/Izm    SHR/Izm    Name updated 68913 APPROVED