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Strain Registration

Strain: F344.GK-(D1Arb42a-D1Rat90)/Swe

Symbol: F344.GK-(D1Arb42a-D1Rat90)/Swe
Strain: F344.GK-(D1Arb42a-D1Rat90)
Substrain: Swe
RGD ID: 631294
Citation ID: RRID:RGD_631294
Ontology ID: RS:0000280
Previously known as: F344.GK-(D1Arb42a-D1Rat90)/Swe; F344.GK-(D1Arb42a-D1Rat90); F344-GK-Niddm1i
Type: congenic
Source: Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
Origin: This congenic strain carries a GK chromosome 1 segment defined by markers D1Arb42a and D1Rat90 transferred to the F344 background
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,699,859 - 259,647,894RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01258,709,726 - 281,795,785RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01266,156,838 - 289,137,268RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41267,110,921 - 267,111,153RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Pathophysiological and genetic characterization of the major diabetes locus in GK rats. Galli J, etal., Diabetes 1999 Dec;48(12):2463-70.
2. Separately inherited defects in insulin exocytosis and beta-cell glucose metabolism contribute to type 2 diabetes. Granhall C, etal., Diabetes. 2006 Dec;55(12):3494-500.
3. High-resolution quantitative trait locus analysis reveals multiple diabetes susceptibility loci mapped to intervals<800 kb in the species-conserved Niddm1i of the GK rat. Granhall C, etal., Genetics. 2006 Nov;174(3):1565-72. Epub 2006 Sep 1.
4. Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats. Lin JM, etal., Diabetes 2001 Dec;50(12):2737-43.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 2 / 1 (D1Rat90)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21259,647,732 - 259,647,894 (+)MAPPER
Rnor_6.01281,795,624 - 281,795,785NCBI
Rnor_5.01289,137,107 - 289,137,268UniSTS
RGSC_v3.41267,110,926 - 267,111,087UniSTS
RGSC_v3.41267,110,921 - 267,111,153RGD
RGSC_v3.11267,322,011 - 267,322,172RGD
Celera1255,291,309 - 255,291,470UniSTS
RH 3.4 Map11708.8RGD
RH 3.4 Map11708.8UniSTS
RH 2.0 Map11313.1999RGD
SHRSP x BN Map1148.15RGD

Flank 1 / 1 (Cyp2c12)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21238,699,859 - 238,757,011 (-)NCBI
mRatBN7.2 Ensembl1238,699,854 - 238,757,019 (-)Ensembl
UTH_Rnor_SHR_Utx1246,821,948 - 246,879,142 (-)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.01253,510,409 - 253,567,584 (-)NCBI
UTH_Rnor_WKY_Bbb_1.01246,163,441 - 246,220,616 (-)NCBI
Rnor_6.01258,709,726 - 258,766,873 (-)NCBI
Rnor_6.0 Ensembl1258,709,721 - 258,766,881 (-)Ensembl
Rnor_5.01266,156,838 - 266,215,677 (-)NCBI
Celera1234,548,215 - 234,605,302 (-)NCBI
Cytogenetic Map1q53NCBI
Strain QTL Data
Symbol Name Trait
Niddm35 Non-insulin dependent diabetes mellitus QTL 35 blood insulin amount   (VT:0001560)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics The isolated islets from these rats do not respond to a rise in glucose concentration with increased insulin secretion rate which leads to defect in insulin secretion. 619688
strain_characteristics The adipose tissue from these rats display postprandial hyperglycemia and reduced insulin action. 619677