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Strain: WKY/Izm

Symbol: WKY/Izm
Strain: WKY
Substrain: Izm
Full Name: Wistar-Kyoto
RGD ID: 631286
Citation ID: RRID:RGD_631286
Ontology ID: RS:0000771
Previously known as: NBRP Rat No: 0195; MDC-02-34
Type: inbred
Source: National BioResource Project for the Rat in Japan
Origin: WKY strain from the Izumo colony
Inbred Generations: F110
Last Known Status: Live Animals

Disease Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
mean arterial blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
cell membrane potential
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
serum triglyceride level
serum total cholesterol level
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum free fatty acids level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
absolute change in systolic blood pressure
absolute change in diastolic blood pressure
both adrenal glands weight to body weight ratio
retroperitoneal fat pad weight to body weight ratio
epididymal fat pad weight to body weight ratio
adipocyte maximal glucose uptake
adipocyte basal glucose uptake
absolute change in adipocyte glucose uptake
adipocyte maximal glucose uptake to basal glucose uptake ratio
absolute change in adipocyte free fatty acid secretion
both testes wet weight to body weight ratio
absolute change in urine norepinephrine level
stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio
absolute change in plasma epinephrine level
absolute change in plasma norepinephrine level
urine norepinephrine excretion rate
urine vanillylmandelic acid excretion rate


References - curated
# Reference Title Reference Citation
1. Fine linkage mapping of the blood pressure quantitative trait locus region on rat chromosome 1. Cui ZH, etal., Hypertens Res 2002 Jul;25(4):605-8.
2. Exaggerated response to cold stress in a congenic strain for the quantitative trait locus for blood pressure. Cui ZH, etal., J Hypertens 2004 Nov;22(11):2103-9.
3. Relation of Blood Pressure Quantitative Trait Locus on Rat Chromosome 1 to Hyperactivity of Rostralventrolateral Medulla. Iigaya K, etal., Hypertension. 2008 Dec 1.
4. Identification of quantitative trait loci for serum cholesterol levels in stroke-prone spontaneously hypertensive rats. Kato N, etal., Arterioscler Thromb Vasc Biol 2000 Jan;20(1):223-9
5. Isolation of a Chromosome 1 Region Affecting Blood Pressure and Vascular Disease Traits in the Stroke-Prone Rat Model. Kato N, etal., Hypertension 2003 Dec;42(6):1191-7. Epub 2003 Nov 17.
6. Genome-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony. Kato N, etal., J Hypertens 2003 Feb;21(2):295-303.
7. Aging and salt-loading modulate blood pressure QTLs in rats. Mashimo T, etal., Am J Hypertens 1999 Nov;12(11 Pt 1):1098-104.
8. A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defined rat strains. Mashimo T, etal., BMC Genet. 2006 Apr 4;7:19.
9. A new genetic locus cosegregating with blood pressure in F2 progeny obtained from stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats. Nabika T, etal., J Hypertens 1993 Jan;11(1):13-8.
10. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
11. RGD Strain RSO annotation pipeline RGD Automated Pipelines
12. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
13. Enhanced sympathetic control of renal function in rats congenic for the hypertension-related region on chromosome 1. Wang T, etal., Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1055-60.
15. Sympathetic regulation of the renal functions in rats reciprocally congenic for chromosome 1 blood pressure quantitative trait locus. Wang T, etal., Hypertens Res. 2008 Mar;31(3):561-8.
16. Evaluation of insulin resistance linkage to rat chromosome 4 in SHR of a Japanese colony. Watanabe T, etal., Biochem Biophys Res Commun 2005 Apr 15;329(3):879-87.
17. A 1.8-Mbp fragment on chromosome 1 affects sympathetic response to stress: evaluation in reciprocal congenic strains between stroke-prone spontaneously hypertensive rat and Wistar-Kyoto rat. Xiao B, etal., J Hypertens. 2010 Nov 8.
18. Sympathetic hyperreactivity to air-jet stress in the chromosome 1 blood pressure quantitative trait locus congenic rats. Yamazato M, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20.
19. Genetic analysis of cataract in Ihara epileptic rat. Yokoyama M, etal., Mamm Genome 2001 Mar;12(3):207-11.


Strain QTL Data
Symbol Name Trait
Bp117 Blood pressure QTL 117 arterial blood pressure trait   (VT:2000000)    
Bp118 Blood pressure QTL 118 arterial blood pressure trait   (VT:2000000)    
Bp119 Blood pressure QTL 119 arterial blood pressure trait   (VT:2000000)    
Bp120 Blood pressure QTL 120 arterial blood pressure trait   (VT:2000000)    
Bp121 Blood pressure QTL 121 arterial blood pressure trait   (VT:2000000)    
Bp122 Blood pressure QTL 122 arterial blood pressure trait   (VT:2000000)    
Bp123 Blood pressure QTL 123 arterial blood pressure trait   (VT:2000000)    
Bp124 Blood pressure QTL 124 arterial blood pressure trait   (VT:2000000)    
Bp125 Blood pressure QTL 125 arterial blood pressure trait   (VT:2000000)    
Bp126 Blood pressure QTL 126 arterial blood pressure trait   (VT:2000000)    
Bp138 Blood pressure QTL 138 arterial blood pressure trait   (VT:2000000)    
Bp84 Blood pressure QTL 84 arterial blood pressure trait   (VT:2000000)    
Bp85 Blood pressure QTL 85 arterial blood pressure trait   (VT:2000000)    
Bp86 Blood pressure QTL 86 arterial blood pressure trait   (VT:2000000)    
Bp87 Blood pressure QTL 87 arterial blood pressure trait   (VT:2000000)    
Gluco11 Glucose level QTL 11 adipocyte glucose uptake trait   (VT:0004185)    
Gluco12 Glucose level QTL12 adipocyte glucose uptake trait   (VT:0004185)    
Lecl1 Lens clarity QTL 1 lens clarity trait   (VT:0001304)    
Lecl2 Lens clarity QTL 2 lens clarity trait   (VT:0001304)    
Scl1 Serum cholesterol level QTL 1 blood cholesterol amount   (VT:0000180)    
Scl2 Serum cholesterol level QTL 2 blood cholesterol amount   (VT:0000180)    
Scl3 Serum cholesterol level QTL 3 blood cholesterol amount   (VT:0000180)    
Stl19 Serum triglyceride level QTL 19 blood triglyceride amount   (VT:0002644)    

Additional Information