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Strain: SDT/Jcl

Symbol: SDT/Jcl
Strain: SDT
Substrain: Jcl
RGD ID: 631219
Citation ID: RRID:RGD_631219
Ontology ID: RS:0000709
Previously known as: SDT; SDT/CrljJcl; JCL:rDB-0002; RS:0002136
Type: inbred
Source: CLEA Japan, Inc
Origin: Established from an outbred colony of Sprague-Dawley (purchased from Charles River Japan) in Torii Pharmaceutical Co. Ltd. This company was merged to CLEA Japan Inc. in 1998. This substrain was established in 1997. Rats with polyuria and glucosuria were bred for 20 generations of brother-sister mating.
Coat Color: Albino
Inbred Generations: F47
Last Known Status: Live Animals (as of 2021-04-23)





References

References - curated
# Reference Title Reference Citation
1. Identification of a major locus for islet inflammation and fibrosis in the Spontaneously Diabetic Torii rat. Fuse M, etal., Physiol Genomics. 2008 Jul 8;.
2. Characteristics of diabetic retinopathy in SDT rats. Kakehashi A, etal., Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):455-61. doi: 10.1002/dmrr.638.
3. Genetic analysis for diabetes in a new rat model of nonobese type 2 diabetes, Spontaneously Diabetic Torii rat. Masuyama T, etal., Biochem Biophys Res Commun 2003 Apr 25;304(1):196-206.
4. A novel model of obesity-related diabetes: introgression of the Lepr(fa) allele of the Zucker fatty rat into nonobese Spontaneously Diabetic Torii (SDT) rats. Masuyama T, etal., Exp Anim. 2005 Jan;54(1):13-20.
5. Diabetes-associated complications in Spontaneously Diabetic Torii fatty rats. Matsui K, etal., Exp Anim. 2008 Apr;57(2):111-21.
6. High levels of pigment epithelium-derived factor in the retina of a rat model of type 2 diabetes. Matsuoka M, etal., Exp Eye Res. 2006 Jan;82(1):172-8. Epub 2005 Jul 27.
7. Effect of food restriction on adipose tissue in spontaneously diabetic Torii fatty rats. Morinaga H, etal., Exp Diabetes Res. 2009;2009:715057. Epub 2009 Aug 19.
8. RGD Strain RSO annotation pipeline RGD Automated Pipelines
9. A new spontaneously diabetic non-obese Torii rat strain with severe ocular complications. Shinohara M, etal., Int J Exp Diabetes Res 2000;1(2):89-100.
10. Newly Developed Rat Model of Chronic Kidney Disease-Mineral Bone Disorder. Watanabe K, etal., J Atheroscler Thromb. 2017 Jul 1. doi: 10.5551/jat.40170.

Region

Strain QTL Data
Symbol Name Trait
Bw82 Body weight QTL 82 body mass   (VT:0001259)    
Gluco13 Glucose level QTL 13 blood glucose amount   (VT:0000188)    
Gluco14 Glucose level QTL 14 blood glucose amount   (VT:0000188)    
Gluco15 Glucose level QTL 15 blood glucose amount   (VT:0000188)    
Gluco35 Glucose level QTL 35 blood glucose amount   (VT:0000188)    
Gluco36 Glucose level QTL 36 blood glucose amount   (VT:0000188)    
Gluco37 Glucose level QTL 37 blood glucose amount   (VT:0000188)    
Gluco38 Glucose level QTL 38 blood glucose amount   (VT:0000188)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Established as a model for nonobese type 2 diabetes which develop hyperglycemia and glucosuria after 20 weeks. 628479
strain_life_disease Established as a model for nonobese type 2 diabetes which develop hyperglycemia and glucosuria after 20 weeks. 631173
strain_life_disease Male rats exhibit glucose intolerance for 20 weeks and develop diabetes spontaneously at 38 weeks. 628479
strain_life_disease Male rats exhibit glucose intolerance for 20 weeks and develop diabetes spontaneously at 38 weeks. 631173
strain_life_disease These have severe ocular complication such as proliferative retinal degeneration ans detachment of retina which resembles human diabetic retinopathy. 631173