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Strain Registration

Strain: FHH-Chr 1BN/Mcwi

Symbol: FHH-Chr 1BN/Mcwi
Strain: FHH-Chr 1BN
Substrain: Mcwi
RGD ID: 629520
Citation ID: RRID:RGD_629520
Ontology ID: RS:0000329
Also Known As: FHH-1BN/Mcwi; FHH-1BN/EurMcwi; FHH-1BN/Mcwi;FHH-1BN/Mcwi;FHH-Chr 1BN/Mcwi; FHH-Chr 1BN/Mcwi; FHH-Chr 1^[BN]/Mcwi
Type: consomic
Available Source: Not Available
Origination: PhysGen
Description: A cross of FHH and BN strains which results in a FHH genomic background with a BN chromosome introgressed
Genetic Markers: hooded
Coat Color: brown
Last Known Status: Live Animals; Cryopreserved Sperm





Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
plasma anion gap
heart wet weight
heart weight to body weight ratio
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
minute ventilation
arterial blood flow rate
tidal volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
serum total cholesterol level
total white blood cell count
serum total bilirubin level
blood pH
partial pressure of blood oxygen
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
urine potassium excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
ratio of change in renal blood flow to change in renal perfusion pressure
serum globulin level

References

References - curated
# Reference Title Reference Citation
1. Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. Fan F, etal., PLoS One. 2014 Nov 14;9(11):e112878. doi: 10.1371/journal.pone.0112878. eCollection 2014.
2. Identification of a QTL on chromosome 1 for impaired autoregulation of RBF in fawn-hooded hypertensive rats. Lopez B, etal., Am J Physiol Renal Physiol. 2006 May;290(5):F1213-21. Epub 2005 Nov 22.
3. Substitution of chromosome 1 ameliorates L-NAME hypertension and renal disease in the fawn-hooded hypertensive rat. Mattson DL, etal., Am J Physiol Renal Physiol 2005 May;288(5):F1015-22. Epub 2005 Jan 11.
4. PhysGen Strains PhysGen strains
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Rf55 Renal function QTL 55 renal blood flow trait   (VT:2000006)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease The blood pressure of females is 113 mmHg and of males is 126 mmHg. 629526
strain_life_disease This consomic strain demonstrates reduced hypertension and renal disease as compared to the paretal FHH/EurMcwi strain 1547854
strain_other The average weight of females is 170g and of males 224g. 629526
strain_reproduction The average litter size is 9.6 pups and the average generation time is 41 days. 629526

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-12 FHH-Chr 1BN/Mcwi    FHH-Chr 1BN/Mcwi    Name updated 68913 APPROVED
2013-08-12 FHH-Chr 1BN/Mcwi    FHH-Chr 1BN/Mcwi    Name updated 68913 APPROVED
2013-08-12 FHH-Chr 1BN/Mcwi    FHH-Chr 1BN/Mcwi    Name updated 68913 APPROVED
2013-08-12 FHH-Chr 1BN/Mcwi    FHH-Chr 1BN/Mcwi    Name updated 68913 APPROVED